2015
DOI: 10.1016/j.aller.2014.07.008
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Comorbid diseases in aspirin-exacerbated respiratory disease, and asthma

Abstract: AERD and asthma are associated with several comorbidities. Even though systemic steroid dependency and severe asthma were significantly more common in the AERD group, comorbidities occurred more frequently in the asthma group. Additional longitudinal studies are needed to more clearly discern if the risk of CAD/CHF is increased in AERD.

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Cited by 15 publications
(12 citation statements)
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“…This is in contrast to other definitions where AERD was used to refer to patients with asthma and intolerance to COX-1 inhibitors but not necessarily chronic sinus disease or nasal polyps, 13, 15, 3235 or to patients who had nasal polyps and COX-1 inhibitor intolerances but not necessarily asthma 36 . Given the lack of universally accepted terminology and definitions, it is common for the same diagnosis ( i.e.…”
Section: Discussionmentioning
confidence: 93%
“…This is in contrast to other definitions where AERD was used to refer to patients with asthma and intolerance to COX-1 inhibitors but not necessarily chronic sinus disease or nasal polyps, 13, 15, 3235 or to patients who had nasal polyps and COX-1 inhibitor intolerances but not necessarily asthma 36 . Given the lack of universally accepted terminology and definitions, it is common for the same diagnosis ( i.e.…”
Section: Discussionmentioning
confidence: 93%
“…Also variants of genes related to arachidonate pathway, inflammation, and immune responses [ 153 , 154 ] as well as staphylococcal superantigens [ 155 ] may play a role in the pathogenesis of AERD. Patients with AERD (majority of them with adult-onset disease) were associated with fewer comorbidities in general (e.g., components of metabolic syndrome) but more coronary heart disease or congestive heart failure when compared to asthma without AERD [ 156 ]. Whether a common pathogenetic component exists remains to be studied.…”
Section: Risk Factors For Adult-onset Asthmamentioning
confidence: 99%
“…Gastroesophageal reflux is also a common comorbidity in obese children and is responsible for worse asthma control [36]. Strikingly, obesity is less frequent in aspirin-exacerbated asthma with polyposis, which is a phenotype usually associated with severe asthma [62]. However, it is also necessary to emphasize that some studies fail to show an association between obesity and poor asthma control in children [63] or in adults [64,65].…”
Section: Should Obesity Be Taken Into Account In the Diagnosis And Fomentioning
confidence: 99%