Comorbid fibromyalgia in migraine patients: clinical significance and impact on daily life

Önder, Halil; Hamamcı, Mehmet; Alpua, Murat; Ulusoy, Ersin Kasım

doi:10.1080/01616412.2019.1630164

Cited by 20 publications

(21 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In a recent report, Onder et al suggest that the presence of fibromyalgia as a comorbidity indicates a more severe migraine. 33 A proposed mechanism of interaction is due to the complex interplay between physiological pathways, including the dopaminergic, serotonergic, and inflammatory cytokine pathways. 34 This may explain why the patients in our study who were diagnosed with fibromyalgia were all classified into the treatment failure group.…”

Section: Discussionmentioning

confidence: 99%

Clinical Outcome of Nerve Decompression Surgery for Migraine Improves with Nerve Wrap

Alizadeh

Kreinces

Smiley

et al. 2021

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

show abstract

Section: Discussionmentioning

confidence: 99%

Clinical Outcome of Nerve Decompression Surgery for Migraine Improves with Nerve Wrap

Alizadeh

Kreinces

Smiley

et al. 2021

Plastic and Reconstructive Surgery - Global Open

View full text Add to dashboard Cite

show abstract

“…Several studies have reported a high prevalence (up to 80%) of FM in patients with CM (9,10,13,14), and there is a large body of evidence that central sensitization comprises the common pathophysiologic basis (1). FM and migraine when present together contribute to increased disability.…”

Section: Discussionmentioning

confidence: 99%

“…FM is a chronic pain syndrome characterized by diffuse pain in addition to disturbed sleep, cognitive impairment, and/or pronounced fatigue (4,5). Many studies have reported high rates of FM in patients with migraine, that range between 10 and 31% in patients with episodic migraine (6)(7)(8)(9)(10)(11)(12), and from 37 to 80% in patients with CM (9,10,13,14). Migraineurs with comorbid FM report more depressive symptoms, higher headache intensity, and more disability (15).…”

Section: Introductionmentioning

confidence: 99%

OnabotulinumtoxinA Is an Effective Treatment for Chronic Migraine in Patients With Comorbid Fibromyalgia

Real

Terán

2020

Front. Neurol.

View full text Add to dashboard Cite

Introduction: Fibromyalgia (FM) is a frequent comorbidity in patients with chronic migraine (CM). PREEMPT trials, which demonstrated the efficacy of OnabotulinumtoxinA (OnabotA) on CM, excluded patients with FM. Our aim was to evaluate the effectiveness of OnabotA in a series of patients with CM and FM. Methods: We analyzed patients with a previous diagnosis of CM and FM who had received sessions of OnabotA quarterly between January 2014 and January 2020 in a specialized Headache Clinic. Primary endpoint was the reduction in moderate to severe headache days at 3, 6, 9, and 12 months. Results: Data were collected from 31 patients with CM and FM that received OnabotA (100% females). Mean age at first procedure was 50.2 ± 11.3 years. Depression (93.5%), other central sensitization syndromes (irritable bowel syndrome, interstitial cystitis, multiple chemical sensitivity, endometriosis, and chronic fatigue syndrome) (48.4%), and medication overuse headache (90.3%) were frequent comorbidities. 48.4% of patients had failed ≥3 preventives previously. The percentage of patients who achieved ≥30 and ≥50% moderate-severe headache reduction on the third month was 65.4 and 48.2%, respectively. Twenty-three patients completed four cycles of treatment, with 13.4 fewer headache days per month than at baseline (p < 0.001). By 1 year, 69.5% had ≥50% reduction of headache frequency and 39.1% had a ≥75% reduction. In 4 cases (21%), OnabotA was interrupted due to a lack of response. Only mild adverse effects were recorded. Conclusion: OnabotA is an effective treatment for CM in patients with FM.

show abstract

“…Fibromyalgia therefore has clear correlations at the level of TMJ and oral health. In particular, as can be seen from the results, patients with TMD and FM show an increase in symptoms [41][42][43][44][45]. Fibromyalgia is diagnosed due to the exclusion of other pathologies and subsequent palpation of the tender points, although it is the patient's overall symptomatic picture that leads to diagnosis.…”

Section: Summary Of Evidencementioning

confidence: 98%

Oral Health and Fibromyalgia Syndrome: A Systemic Review

Stefano

Bruno

Muscatello

et al. 2020

JFMK

View full text Add to dashboard Cite

Fibromyalgia is a syndrome currently considered idiopathic and multifactorial rheumatic that causes an increase in muscle tension and is characterized by muscle pain and chronic fibrous tissues—widespread, fluctuating and migrating—associated with stiffness, asthenia, cognitive disorders, insomnia or sleep disorders, alterations in sensitivity to stimuli. In affected patients, there may be anxiety or depressive disorder development. The aim of this study is, with the help of an interdisciplinary team, to evaluate the correlations between this syndrome and oral health. A literature review was conducted, analyzing the most common scientific databases, more than 200 studies were obtained. Subsequently to the application of filters and revision by the authors, only 18 articles were considered eligible for this review. From the results, it is clear that the correlations between fibromyalgia and oral health mainly concern pain in the oro-maxillofacial district, especially in the temporomandibular joint. This certainly could help for faster diagnosis of the syndrome, which is currently difficult to identify.

show abstract

Comorbid fibromyalgia in migraine patients: clinical significance and impact on daily life

Cited by 20 publications

References 34 publications

Clinical Outcome of Nerve Decompression Surgery for Migraine Improves with Nerve Wrap

Clinical Outcome of Nerve Decompression Surgery for Migraine Improves with Nerve Wrap

OnabotulinumtoxinA Is an Effective Treatment for Chronic Migraine in Patients With Comorbid Fibromyalgia

Oral Health and Fibromyalgia Syndrome: A Systemic Review

Contact Info

Product

Resources

About