Comorbid Mental Disorders and 6-Month Symptomatic and Functioning Outcomes in Chinese University Students at Clinical High Risk for Psychosis

Abstract

BackgroundHigh rates of non-psychotic psychopathological symptoms have been observed in clinical population at clinical high risk (CHR) for psychosis. These comorbid disorders affected the baseline functional level of CHR patients. However, little is known about the comorbid mental disorder in CHR individuals in non-clinical adolescent population. This study aimed to investigate the comorbid mental disorder in non-clinical CHR adolescents and the impact on attenuated psychosis symptoms (APS) as well as clinical outcome.MethodsThe sample consisted of 32 CHR students, who were screened from 2,800 university students. CHR status was evaluated with the Structured Interview of Prodromal Syndromes, comorbid mental disorder diagnoses with the International Neuropsychiatric Interview.ResultsIn the CHR sample, 46.9% was found at least one non-psychotic comorbid mental disorder. The CHR participants presenting comorbid mental disorder had significantly more severity of APS than those without comorbid mental disorders, and the remission rate at 6-month follow-up is significantly higher in the individuals without comorbid mental disorders at baseline.ConclusionIn the non-clinical sample of individuals at CHR, non-psychotic comorbid mental disorders are common and anxiety disorder is most frequent. Copresence of anxiety and/or depression is related to higher level of attenuated psychotic symptoms and unfavorable clinical outcome at 6-month follow-up. Assessment and intervention in anxiety and depression for non-clinical CHR adolescents are suggested.

Prevalence and Psychosocial Correlates of Mental Health Outcomes Among Chinese College Students During the Coronavirus Disease (COVID-19) Pandemic

“…Rates of depressive symptoms (23.3%) matched those (21.16%) estimated in a previous study ( 12 ). Also, two concomitant symptomatic dimensions among anxiety, depressive, and posttraumatic symptoms affected 4.1% of participants and two of them in 7.0%, confirming previous findings outside of COVID-19 context ( 41 ). Such comorbidity ( e.g.…”

Motion energy analysis during speech tasks in medication-naïve individuals with at-risk mental states for psychosis

“…First, given the cross-sectional design with a modest and heterogeneous sample, it is difficult to interpret null data. But despite being heterogeneous, our sample did not differ demographically between the groups analyzed and considering the use of a non-help-seeking sample, our sample size is similar to those from previous studies 49 , 50 . Second, the absence of clinical ratings of abnormal movements for estimations of construct or convergent validity.…”

Neural correlates of emotional processing in psychosis risk and onset – A systematic review and meta-analysis of fMRI studies

“…Future studies reporting this will expand our understanding of emotional responsivity according to CHRp subtype and clarify whether this is a potential source of heterogeneity in imaging findings. Finally, people at CHRp often have a formal diagnosis of another Axis I disorder, such as anxiety or depression ( Shi et al, 2017 ; Fusar-Poli et al, 2014 ), and the potential concomitant use of antidepressant or anxiolytic medication may have an effect on the imaging data in response to emotion stimuli ( Murphy et al, 2009 ; Paulus et al, 2005 ). More consistent task paradigm, stimuli and CHRp assessment criteria across studies would aid understanding of the nature of emotion-related neuroimaging abnormalities in the CHRp state.…”