Comorbid neuropathologies in migraine

Sacco, Simona; Olivieri, Luigi; Bastianello, Stefano; Carolei, Antonio

doi:10.1007/s10194-006-0300-8

Cited by 32 publications

(23 citation statements)

References 28 publications

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“…Although the evidence supporting an etiologic relationship between migraine and ischemic stroke risk is substantial (Cole & Kittner 2010; Sacco et al 2012; Sacco et al 2008; Sacco et al 2006), the precise mechanism(s) driving this relationship remains uncertain. Stroke, which typically affects older individuals, can be targeted for prevention by optimizing well-established standard vascular risk factors such as hypertension, diabetes, and hypercholesterolemia, among others.…”

Section: Introductionmentioning

confidence: 99%

Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study

et al. 2013

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In a recent meta-analysis migraine was associated with a two-fold increase in stroke risk. While the mechanism driving this association is unknown, one intriguing hypothesis is that migraineurs are genetically predisposed to developing ischemic stroke. Mutations in the ATP1A2 gene are implicated in familial hemiplegic migraine type II and increase the severity of ischemic brain injury in animal models. To further explore these observations, we assessed the association between ATP1A2 polymorphisms, migraine, and the risk of ischemic stroke in participants of the Genetics of Early-Onset Stroke Study, a population-based case–control study of ischemic stroke among men and women aged 15–49. Using responses to a headache symptoms questionnaire, subjects were classified as having no migraine, or migraine with or without visual aura. Evaluating a total of 134 ATP1A2 polymorphisms genotyped using a combination of Illumina platforms (Cardiovascular Gene-centric 50 K SNP Array and HumanOmni1-Quad_v1-0_B Bead Chip), only one polymorphism (rs2070704) demonstrated a nominally significant association with stroke in an age-, gender-, ethnicity-adjusted model (OR = 0.83, 95% CI = 0.71-0.98, p = 0.025) and in a vascular risk factor model adjusting for age, gender, ethnicity, hypertension, diabetes, smoking, and myocardial infarction (OR = 0.74, 95% CI = 0.63-0.89, p = 0.001). Ethnicity-stratified analyses demonstrated a significant association for rs2070704 among African-Americans (OR = 0.68, 95% CI = 0.53-0.90, p = 0.005) but not Caucasians (OR = 0.82, 95% CI = 0.64-1.04, p = 0.107). These associations were unchanged when migraine subtypes were included as co-variates. We did not observe an association between ATP1A2 polymorphisms and migraine. While our results do not demonstrate a strong relationship between ATP1A2 polymorphisms and migraine associated stroke risk, the results are hypothesis generating and indicate that an association between ATP1A2 polymorphisms and stroke risk may exist. Additional studies are required.Electronic supplementary materialThe online version of this article (doi:10.1186/2193-1801-2-46) contains supplementary material, which is available to authorized users.

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Section: Introductionmentioning

confidence: 99%

Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study

et al. 2013

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“…There seems to be a bi-directional relationship between migraine and depression, with each disorder increasing the risk of the other one [7][8][9][10] . however there are few studies evaluating the severity of depressive symp-toms in patients with chronic migraine 10 .…”

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confidence: 99%

Correlation between migraine subtipes and depression

Domingues

Costa

Silva

et al. 2008

Arq. Neuro-Psiquiatr.

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-This study has evaluated depression in patients with episodic migraine (n=98), chronic migraine without medication overuse (n=23), and chronic migraine with medication overuse (n=57). The Beck Depression Inventory (BDI) was used to evaluate depressive symptoms in these three groups. The mean BDI score obtained in all patients was higher than that observed in asymptomatic subjects (episodic migraine=16.09±11.79, chronic migraine with medication overuse=18.91±12.53, chronic migraine without medication overuse=19.83±14.79). This finding corroborates previous studies suggesting a co-morbid association between migraine and depression. Depression did not seem to be crucial in the transformation of migraine as the median BDI scores did not differ significantly between patients with episodic and chronic migraine. The median BDI scores of the patients with chronic migraine with medication overuse and that patients with chronic migraine without medication overuse were similar as well. Therefore, medication overuse behavior may not be related with depression.Key worDs: migraine, chronic migraine, analgesic abuse, depression. Correlação entre subtipos de migrânea e depressãoResumo -este estudo avaliou a depressão em pacientes com migrânea episódica (n=98), migrânea crônica com uso abusivo de analgésicos (n=57) e migrânea crônica sem uso abusivo de medicamentos analgésicos (n=23). o Inventário de Depressão de Beck (IDB) foi usado para avaliar sintomas depressivos nos três grupos. As médias dos escores de IDB encontradas (migrânea episódica=16.09±11.79, migrânea crônica com uso abusivo de analgésicos=18.91±12.53, migrânea crônica sem uso abusivo de analgésicos=19.83±14.79) foram maiores do que as observadas em indivíduos assintomáticos. Tais resultados confirmam estudos prévios indicando uma relação de comorbidade entre migrânea e depressão. os dados não sugerem que a depressão seja um fator determinante da transformação da migrânea episódica em migrânea crônica, pois nestes dois grupos as medianas dos escores de IDB foram semelhantes. os escores de IDB foram semelhantes entre os pacientes com migrânea crônica com e sem uso abusivo de analgésicos. Portanto, o comportamento de ingerir abusivamente analgésicos não parece estar relacionado com a depressão.PAlAvrAs-chAve: migrânea, migrânea crônica, abuso de analgésicos, depressão.1 headache clinic -escola superior de ciências da saúde de vitória, vitória es, Brazil (eMescAM);

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“…However, the distinctiveness and severity of MA is such that prior attacks are unlikely to escape the memory. Nothing in the history suggested TIAs [1] or other comorbid pathologies [2]. Spontaneous, atraumatic, dissection of the carotid [5] or vertebral [6] artery has been reported to mimic migraine but symptoms are usually transient rather than persistent as in this case.…”

mentioning

confidence: 64%

“…De novo diagnosis above this age may require investigation to exclude other causes (transient ischaemic attacks [TIAs], neoplasm, temporal arteritis, epilepsy, pituitary macroadenoma [1]) and comorbid pathologies, especially stroke [2]. Cases of de novo postmenopausal migraine are reported, sometimes with familial basis [3], but these episodes are usually without aura.…”

mentioning

confidence: 99%

Late onset migraine with aura: how old is too old?

Larner

2007

J Headache Pain

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Comorbid neuropathologies in migraine

Cited by 32 publications

References 28 publications

Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study

Polymorphisms in migraine-associated gene, atp1a2, and ischemic stroke risk in a biracial population: the genetics of early onset stroke study

Correlation between migraine subtipes and depression

Late onset migraine with aura: how old is too old?

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