Comorbid post-traumatic stress disorder in alcohol use disorder: relationships to demography, drinking and neuroimmune profile

Bramness, Jørgen G.; Lien, Lars

doi:10.1186/s12888-017-1479-8

Cited by 28 publications

(23 citation statements)

References 61 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…However, we found no relationship between levels of cytokines and AUDIT. This differed from our previous cross-sectional study in Nepal, where we found increased pro-inflammatory cytokines in AUD (alcohol use disorder) patients with comorbid MDD, but not with PTSD [ 43 , 44 ]. In line with the findings in that study, we investigated whether there were different relationships between cytokine levels and levels of depression in those with or without an alcohol problem, but analyzing the data in this way by stratifying according to AUDIT score did not reveal any such effect in the present study.…”

Section: Discussioncontrasting

confidence: 99%

The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment

et al. 2018

Self Cite

View full text Add to dashboard Cite

BackgroundDepression is associated with immunological responses as reflected by altered levels of circulating cytokines. Alcohol use and trauma may modulate immune activity, and few studies have investigated these factors in depressed patients. We aimed to explore the association between circulating peripheral cytokine levels and degree of depressive symptoms, taking trauma and alcohol into account.MethodsThe study was a cross-sectional assessment of patients at admission to a specialized psychiatric center in Norway. A total of 128 patients were included. Information was gathered using the self-administered questionnaires Beck Depression Inventory-II (BDI-II) and the Alcohol Use Disorders Identification Test (AUDIT), in addition to clinical interviews recording childhood or adult life trauma. Serum levels of the cytokines Interleukin-1β (IL-1β), Interleukin-1 Receptor Antagonist (IL-1RA), Tumor Necrosis Factor-α (TNF-α) and the chemokine Monocyte Chemoattractant Protein-1 (MCP-1) were assessed. A Luminex bead-based multiplex assay was used for cytokine measurements. Patient cytokine levels were compared to those of healthy volunteers by the Mann-Whitney U test.ResultsLevels of cytokines did not differ across patients with mild, moderate and severe depression. AUDIT score was not related to cytokine levels, but to level of depression. A history of trauma was related to higher levels of IL-1RA and TNF-α (p = 0.048 and p = 0.033, respectively), especially among the severely depressed. Serum levels of MCP-1 and TNF-α were significantly higher among psychiatric patients than in healthy volunteers.ConclusionsFindings indicate that depression was not related to levels of circulating cytokines among patients in treatment, but that traumatized patients had higher levels of IL-1RA and TNF-α than patients without trauma experience. The lack of relationship between cytokine level and depression was evident both in those without and with trauma.

show abstract

Section: Discussioncontrasting

confidence: 99%

The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment

et al. 2018

Self Cite

View full text Add to dashboard Cite

show abstract

“…Neupane ve ark. 'nın (19) araştırmasında, ciddi trafik kazası geçirme sıklığı %46.5, ölüme tanık olma/şiddet/ciddi yaralanma %24.1, saldırgan şiddeti %19.8, silahla tehdit/ kaçırılma/esir alınma %17.6, diğer ciddi travma %29.9, ani beklenmedik yakın kaybı %13.3 bulunmuştur. Dutcher ve ark.…”

Section: Discussionunclassified

Travmatik Yaşantının Trafik Cezalarına Etkisi: Alkollüyken Araç Kullanan Sürücüler Bağlamında Değerlendirilmesi

Yeşil¹,

Demircan²,

Aker³

2020

Bull Leg Med

View full text Add to dashboard Cite

Amaç: Bu çalışmada alkollüyken araç kullanımı olan sürücülerin yaşam boyu travmatik yaşantı sıklıklarını tespit etmek, trafik ceza bilgilerini incelemek, travmatik öykü ve ceza bilgileri arasındaki ilişkiyi incelemek amaçlanmıştır. Gereç ve Yöntem: Araştırma Kasım 2015- Haziran 2016 tarihleri arasında Bursa Sağlık Müdürlüğü tarafından yürütülen Sürücü Davranışları Geliştirme Eğitimine katılan 295 katılımcıyla gerçekleştirilmiştir. Sürücülere araştırmacılar tarafından hazırlanan travmatik yaşantıların ve demografik bilgilerin yer aldığı Sürücü Bilgi Formu uygulanmıştır. Ayrıca sürücülerin sürücü belgesi ceza bilgileri İl Emniyet Müdürlüğü’ne resmi yazı ile başvurularak talep edilmiş, gerekli izinler alındıktan sonra trafik ihlal bilgilerinin yer aldığı Sürücü Belgesi Ceza bilgileri ve yaşam boyu travmatik yaşam öyküsü arasındaki ilişki incelenmiştir. Bulgular: Sürücülerin yaş ortalaması 40,47±9,48’tir. Sürücülerin 33’ü (%11,2) hayatını tehdit eden bir hastalık ya da yaralanma geçirdiğini, 32’si (%10,8) ciddi bir kaza geçirme ya da ciddi bir şekilde yaralandığını, 28’i (%9,5) kendisine fiziksel şiddet ya da silah kullanıldığını belirtmiştir. Sürücülerden 63’ü (%21,4) ailesinden birini (sevgili, eş, ya da çok yakın arkadaş) bir kaza, cinayet ya da intihar sonucu kaybettiğini, 18’i (%6,1) ölümle ya da ciddi yaralanmayla tehdit gördüğünü belirtmiştir. Sürücülerin en sık %46,9 ile 34.maddeyi ihlal ettiği daha sonra %45,8 ile 51/2-A, %38,2 ile 78/1-A, %30,2 ile 118/7. Maddeyi ihlal ettikleri tespit edilmiştir. Herhangi birinden tekmelenme, dövülme, tokat atılma ya da başka yolla fiziksel zarar görenler ile 78/1-A ihlal maddesi arasında ilişki bulunmuştur [χ²(2) =7.19, p<.00]. Sonuç: Alkollüyken araç kullanma öyküsü olan sürücülerle yapılan bu çalışmada, yaşam boyu travmatik öykü ve trafik ihlalleri arasında anlamlı bir ilişki bulunmuştur. Anahtar Kelimeler: Adli Bilimler; Travmatik Yaşam Olayı; Suç

show abstract

“…In addition, approximately 50% of AUD patients also suffer of post-traumatic stress disorder (PTSD) (2,3). The patients suffering from AUD and PTSD manifest greater severity of psychiatric pathologies and are more resistant to therapeutic interventions (4). AUD therefore represents a major health problem worldwide entailing social, personal and legal aspects.…”

Section: Introductionmentioning

confidence: 99%

Transcriptomic analysis reveals moderate modulation of macrophage migration inhibitory factor superfamily genes in alcohol use disorders

et al. 2020

View full text Add to dashboard Cite

Alcohol use disorder (AUD) is a primary, chronic and relapsing disease of brain reward, motivation and memory, which is associated with several comorbidities, including major depression and post-traumatic stress disorder. It has been revealed that Ibudilast (IBUD), a dual inhibitor of phosphodiesterase-4 and-10 and of macrophage migration inhibitory factor (MIF), exerts beneficial effects on AUD in rodent models and human patients. Therefore, IBUD has attracted increasing interest, with research focusing on the elucidation of the pathogenic role of MIF and its homologue, D-dopachrome tautomerase (DDT), in the pathogenesis and maintenance of AUD. By using DNA microarray analysis, the current study performed a transcriptomic expression analysis of MIF, DDT and their co-receptors, including CD74, C-X-C chemokine receptor (CXCR)2, CXCR4 and CXCR7 in patients with AUD. The results revealed that the transcriptomic levels of MIF, DDT and their receptors were superimposable in the prefrontal cortex of rodents and patients with AUD and human patients. Furthermore, peripheral blood cells from heavy drinkers exhibited a moderate increase in MIF and DDT levels, both at the baseline and following exposure to alcohol-associated cues, based on individual situations that included alcohol-related stimuli resulting in subsequent alcohol use (buying alcohol and being at a bar, watching others drink alcohol). Considering the overlapping effects of MIF and DDT, the inverse Fisher's χ 2 test was performed on unadjusted P-values to evaluate the combined effect of MIF and DDT. The results revealed a significant increase in these cytokines in heavy drinkers compared with controls (moderate drinkers). To the best of our knowledge, the present study demonstrated for the first time that MIF and DDT expression was upregulated in the blood of patients with AUD. These results therefore warrant further study to evaluate the role of MIF and DDT in the development and maintenance of AUD, to evaluate their use as biomarkers to predict the psychotherapeutic and pharmacological response of patients with AUD and for use as therapeutic targets.

show abstract

Comorbid post-traumatic stress disorder in alcohol use disorder: relationships to demography, drinking and neuroimmune profile

Cited by 28 publications

References 61 publications

The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment

The effect of trauma and alcohol on the relationship between level of cytokines and depression among patients entering psychiatric treatment

Travmatik Yaşantının Trafik Cezalarına Etkisi: Alkollüyken Araç Kullanan Sürücüler Bağlamında Değerlendirilmesi

Transcriptomic analysis reveals moderate modulation of macrophage migration inhibitory factor superfamily genes in alcohol use disorders

Contact Info

Product

Resources

About