Comorbid Problems in ADHD: Degree of Association, Shared Endophenotypes, and Formation of Distinct Subtypes. Implications for a Future DSM

Rommelse, Nanda; Altink, Marieke E.; Fliers, Ellen A.; Martin, Neilson; Buschgens, Cathelijne J. M.; Hartman, Catharina A.; Buitelaar, Jan K.; Faraone, Stephen V.; Sergeant, Joseph A.; Oosterlaan, Jaap

doi:10.1007/s10802-009-9312-6

Cited by 114 publications

(95 citation statements)

References 48 publications

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“…The results of this study showed that the motor performance of GII students was superior than the performance of GI students, in almost all motor areas assessed; which supports the literature (Rochelle & Talcott, 2006;Rommelse et al, 2009;Capellini, Germano, & Padula, 2010;Rosenblum, Aloni, & Josman, 2010;.…”

Section: Discussionsupporting

confidence: 87%

Motor Profile of Students With Dyslexia

Okuda¹,

Ramos²,

Santos³

et al. 2014

JPR

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In the presence of developmental dyslexia, there is high probability of motor difficulties being present as well purposes: The purposes of this study were to characterize and compare the motor performance of students with dyslexia with students with good academic performance and to identify the presence of the DCD (developmental coordination disorder) co-occurring with developmental dyslexia. A total of 79 students participated in the research, both genders, from 8 to 11 years old, from 3rd to 5th grades, and were divided into Group I: 19 students with developmental dyslexia and Group II: 60 students with good academic performance. All the students were assessed using "The Bruininks-Oseretsky Test of Motor Proficiency" (second edition), to measure the motor skills and the pattern and differences between groups. The results of this study showed that the motor performance of Group II students was superior to the performance of students of Group I in almost all motor areas assessed but both groups performed less well than they should have for their chronological age. The results of this study indicate that occupational therapists, speech therapists and educators need to be aware of the presence of motor impairments and the need for early intervention in both the academic and clinical environments, in order to ensure that early identification and diagnosis of possible co-occurrences, such as DCD, and the impact on learning to guarantee more appropriate clinical and educational assistance for this population.This may also indicate that increased exposure to movement may be important to limit some of the secondary health consequences in children in Brazil.

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Section: Discussionsupporting

confidence: 87%

Motor Profile of Students With Dyslexia

Okuda¹,

Ramos²,

Santos³

et al. 2014

JPR

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“…It will be worthwhile to examine MAOB and evaluate the gene-gene interaction between MAOA and MAOB in further research given the important role of MAOB in the metabolism of DA. In recent years, endophenotypes have attracted attention in genetic studies of ADHD [Doyle et al, 2005a;Doyle et al, 2005b;Rommelse et al, 2008b;Rommelse et al, 2008c;Rommelse et al, 2009;Uebel et al, 2010]. Increased penetrance of the endophenotype compared to the phenotype proper may help us to find candidate genes.…”

Section: Discussionmentioning

confidence: 99%

Association analyses of MAOA in Chinese Han subjects with attention‐deficit/hyperactivity disorder: Family‐based association test, case–control study, and quantitative traits of impulsivity

Liu

Guan

Chen

et al. 2011

American J of Med Genetics Pt B

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Monoamine oxidase A (MAOA) plays a critical role in the metabolism of monoamine neurotransmitters including serotonin (5-HT), norepinephrine (NE), and dopamine (DA). Genetic studies have found an association between MAOA and attention-deficit/hyperactivity disorder (ADHD), especially impulsivity. However, there has been inconsistency among studies which may be due to the complexity and heterogeneity of ADHD, including its sexual dimorphism and the presence of several subtypes. We conducted transmission disequilibrium tests (TDTs) in 1,253 trios and found no association between five single nucleotide polymorphisms (SNPs) of MAOA with ADHD in general or in the predominantly inattentive (ADHD-I) or combined types (ADHD-C), but with the predominantly hyperactive/impulsivity type (ADHD-HI). The association with MAOA was restricted to males, especially males with ADHD-HI. Logistic regression analyses of data from 1,824 cases and 957 controls did not indicate any association. We used analysis of covariance to analyze the association between MAOA genotype with the "inhibit" factor of the Behavior Rating Inventory of Executive Function (BRIEF) in 640 probands and performance on the Stroop test in 810 probands. Probands homozygous for risk alleles found in the TDT test had higher "inhibit" scores on the BRIEF scale which represents more severe impulsivity; this results also was restricted to males. No association was found with Stroop test performance. In conclusion, our results provide some evidence that MAOA may be associated with the ADHD-HI subtype and support the association between MAOA and impulsivity, which may be a potential endophenotype of ADHD. However, the results were strongly influenced by gender.

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“…It has proven useful in populations other than ASD such as ADHD for characterizing subthreshold ASD problems (Nijmeijer et al 2008) and delinquent groups ('t Hart-Kerkhoffs, Jansen, Doreleijers, Vermeiren, Minderaa, Geluk et al 2012). The validity of the CSBQ also follows from genetic (Nijmeijer et al 2010), neurocognitive (Blijd-Hoogewys, van Geert, Serra, andGeurts, Luman, and van Meel 2008;Rommelse et al 2009) and behavioral (de Bildt et al 2005;Jaspers et al 2013) studies.…”

Section: Instrumentsmentioning

confidence: 99%

Integrating Autism-Related Symptoms into the Dimensional Internalizing and Externalizing Model of Psychopathology. The TRAILS Study

Noordhof

Krueger

Ormel

et al. 2014

J Abnorm Child Psychol

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Problems associated with Autism Spectrum Disorder (ASD) occur frequently in the general population and often co-occur with problems in other domains of psychopathology. In the research presented here these co-occurrence patterns were investigated by integrating a dimensional approach to ASDs into the more general dimensional framework of internalizing and externalizing psychopathology. Factor Analysis was used to develop hierarchical and bi-factor models covering multiple domains of psychopathology in three measurement waves of a longitudinal general population sample (N = 2,230, ages 10-17, 50.8% female). In all adequately fitting models, autism related problems were part of a specific domain of psychopathology that could be distinguished from the internalizing and externalizing domains. Optimal model fit was found for a bi-factor model with one non-specific factor and four specific factors related to internalizing, externalizing, autism spectrum problems and problems related to attention and orientation. Autism-related problems constitute a specific domain of psychopathology that can be distinguished from the internalizing and externalizing domains. In addition, the co-occurrence patterns in the data indicate the presence of a strong general factor.

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Comorbid Problems in ADHD: Degree of Association, Shared Endophenotypes, and Formation of Distinct Subtypes. Implications for a Future DSM

Cited by 114 publications

References 48 publications

Motor Profile of Students With Dyslexia

Motor Profile of Students With Dyslexia

Association analyses of MAOA in Chinese Han subjects with attention‐deficit/hyperactivity disorder: Family‐based association test, case–control study, and quantitative traits of impulsivity

Integrating Autism-Related Symptoms into the Dimensional Internalizing and Externalizing Model of Psychopathology. The TRAILS Study

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