Comorbidities amongst patients with multiple sclerosis: a population‐based controlled study

Kang, Jiunn Horng; Chen, Y.‐H.; Lin, Herng‐Ching

doi:10.1111/j.1468-1331.2010.02971.x

Cited by 111 publications

(187 citation statements)

References 14 publications

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“…To determine if conditions recorded in the EPIOC users were similar or different to those previously reported, they were classified as comorbidities if used in the self-report questionnaires of Marrie et al [12] and Horton et al [10]. They were also compared with the comorbidities noted by Kang et al in Chinese people with MS [11].…”

Section: Data Collectionmentioning

confidence: 99%

“…The aim of this study is to describe the problematic clinical features of powered wheelchair users with severely disabling MS. We shall explore the complexities of comorbidities, clinical features of MS and conditions secondary to disability influencing prescription and compare our findings of comorbidity recorded in the clinic with the classifications used in self-report questionnaires in those mildly or moderately disabled with MS [10][11][12].…”

Section: Introductionmentioning

confidence: 99%

“…spasticity and fatigue are also relevant to wheelchair use. Previous studies in PwMS that focussed on comorbidities have used self-report questionnaires recalling comorbidities at diagnosis and disease onset [12], in those with mild disabilities [10] and in a group of PwMS seeking ambulatory care or hospitalisation [11]. The comorbidities may be associated with differences in clinical characteristics [12] and are likely to be very different in severe disabling MS from those found early in the course of MS due to disease progression and the impact of long-term physical and functional limitations for those who require a wheelchair for mobility.…”

Section: Introductionmentioning

confidence: 99%

“…In addition to mobility disability, PwMS frequently have comorbidities that may affect treatment decisions [10][11][12]. The number of comorbid conditions are thought to increase with DSS and adversely affect health-related quality of life [13].…”

Section: Introductionmentioning

confidence: 99%

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Problematic clinical features of powered wheelchair users with severely disabling multiple sclerosis

Souza

Frank

2014

Disability and Rehabilitation

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Purpose: The aim of this study is to describe the clinical features of powered wheelchair users with severely disabling multiple sclerosis (MS) and explore the problematic clinical features influencing prescription. Method: Retrospective review of electronic and case note records of recipients of electric-powered indoor/outdoor powered wheelchairs (EPIOCs) attending a specialist wheelchair service between June 2007 and September 2008. Records were reviewed by a consultant in rehabilitation medicine, data systematically extracted and entered into a computer database. Further data were entered from clinical records. Data were extracted under three themes; demographic, diagnostic, clinical and wheelchair factors. Results: Records of 28 men mean age 57 (range 37-78, SD 12) years and 63 women mean age 57 (range 35-81, SD 11) years with MS were reviewed a mean of 64 (range 0-131) months after receiving their wheelchair. Twenty two comorbidities, 11 features of MS and 8 features of disability were thought to influence wheelchair prescription. Fifteen users were provided with specialised seating and 46 with tilt-in-space seats. Conclusions: Our findings suggest that people with severe MS requiring an EPIOC benefit from a holistic assessment to identify problematic clinical features that influence the prescription of the EPIOC and further medical and therapeutic interventions. ä Implications for RehabilitationPeople with multiple sclerosis (MS), referred for an EPIOC, require a full clinical assessment to identify problematic clinical features that are potentially treatable and/or can be accommodated through specialised seating and tilt. The beneficial effects of TIS should be considered for all EPIOC users with MS and particularly for those with comorbidity Poorly controlled spasticity, when identified in people with MS, should be managed through positioning in the chair, pressure-relieving cushion and referral for medical management.

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Section: Data Collectionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Problematic clinical features of powered wheelchair users with severely disabling multiple sclerosis

Souza

Frank

2014

Disability and Rehabilitation

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“…Data from population-based studies suggest that some diseases including epilepsy, migraine, irritable bowel syndrome, systemic lupus erythematosus, depression, anemia and rheumatoid arthritis are more prevalent among individuals with MS compared to the general population [40,41]. These comorbid medical conditions, or the medications used to treat them, may have effects on the unborn child.…”

Section: Potential Confounding Factorsmentioning

confidence: 99%

Safety of disease-modifying drugs for multiple sclerosis in pregnancy: current challenges and future considerations for effective pharmacovigilance

Wang

Guimond

et al. 2013

Expert Review of Neurotherapeutics

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Autoimmune disease in people with multiple sclerosis and their relatives: a systematic review and meta-analysis

Dobson

Giovannoni

2013

J Neurol

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Additional autoimmune diseases in people with multiple sclerosis (MS) and their relatives have been studied many times. Studies have employed different designs, and yielded conflicting results. We performed a systematic review, and calculated overall risk of additional autoimmune diseases in people with MS and their first-degree relatives. PubMed and Web of Science were searched. Thyroid disease, diabetes, inflammatory bowel disease, psoriasis, rheumatoid arthritis (RA) and systemic lupus erythematosus (SLE) were studied. A generic inverse variance model was used, and subgroup analysis was used to explore heterogeneity. The OR of thyroid disease was increased in both people with MS (OR 1.66; p < 0.00001) and their relatives (OR 2.38; p < 0.00001). A similar association was seen between MS and inflammatory bowel disease (OR 1.56; p < 0.0001) and psoriasis (OR 1.31; p < 0.0001), although not in relatives. There was no increase in the rate of either SLE or RA. Studies examining diabetes showed significant heterogeneity and evidence of publication bias. There is an increase in the rate of certain autoimmune diseases in people with MS and their first-degree relatives. However, this does not extend to all conditions studied. Given the nonspecific clinical presentation of thyroid disease, it should be considered in all people with MS presenting with nonspecific symptoms.

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Comorbidities amongst patients with multiple sclerosis: a population‐based controlled study

Abstract: Patients with MS had higher risk of multiple medical comorbidities compared to a matched control group in an ethnic Chinese population.

Cited by 111 publications

References 14 publications

Problematic clinical features of powered wheelchair users with severely disabling multiple sclerosis

Problematic clinical features of powered wheelchair users with severely disabling multiple sclerosis

Safety of disease-modifying drugs for multiple sclerosis in pregnancy: current challenges and future considerations for effective pharmacovigilance

Autoimmune disease in people with multiple sclerosis and their relatives: a systematic review and meta-analysis

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