Comorbidities and perceived health status in persons with history of cancer in the USA

Obeng-Kusi, Mavis; Vardy, Janette; Bell, Melanie L.; Choi, Briana M.; Axon, David R.

doi:10.1007/s00520-022-07479-4

Cited by 3 publications

(3 citation statements)

References 26 publications

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“…In our study, the total perceived well-being level was higher in patients who were older, males and did not receive immunotherapy. A US-based study on patients with a history of cancer showed that the level of perception of health status was positively affected with age (Obeng-Kusi et al, 2022). It is thought that perceived well-being increases with increasing age in patients who develop CIPN; this is because of the increase in satisfaction with life by re-signifying life with increasing age (Yukay Yüksel et al, 2021).…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy-induced peripheral neuropathy according to biopsychosocial model: A descriptive cross-sectional correlational study

Sevinçelli,

Ozdemir

2024

Multidiscip. Sci. J.

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The present study aimed to assess the biological health, perceived well-being and social well-being of cancer patients with CIPN within the scope of the biopsychosocial model. This study was conducted in oncology clinics and outpatient clinics of a research hospital. The sample comprised 109 patients who met the following inclusion criteria: age ≥ 18 years, completed at least three cycles of taxane and platinum chemotherapy treatment, showed peripheral neuropathy symptoms, could communicate in Turkish and provided consent to participate in the study. For data collection, Patient Information Form, Chemotherapy-induced Peripheral Neuropathy Scale (EQRTC QLQ CIPN20), Perceived Well-being Scale and Social Well-being Scale were used. The EQRTC QLQ CIPN20 score was higher in those with high school and higher education than in those with primary school education and below. Perceived well-being was higher with the increase in age, in males, patients receiving only chemotherapy but no immunotherapy, patients without additional stressors, unemployed patients, patients receiving care support from their spouses at home and patients living with their spouses. The social well-being level was higher in those with higher age and number of treatments, those without stem cell transplantation, those without additional stressors, those with primary school education and below and those living alone.

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Section: Discussionmentioning

confidence: 99%

Chemotherapy-induced peripheral neuropathy according to biopsychosocial model: A descriptive cross-sectional correlational study

Sevinçelli,

Ozdemir

2024

Multidiscip. Sci. J.

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“…In our study, the total perceived well-being level was higher in patients who were older, males and did not receive immunotherapy. A US-based study on patients with a history of cancer showed that the level of perception of health status was positively affected with age [27]. It is thought that perceived well-being increases with increasing age in patients who develop CIPN; this is because of the increase in satisfaction with life by re-signifying life with increasing age [28].…”

Section: Discussionmentioning

confidence: 99%

Chemotherapy-induced Peripheral Neuropathy According to Biopsychosocial Model: A Descriptive Cross-Sectional Correlational Study

Sevincelli,

Ozdemir

2023

Preprint

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Purpose The present study aimed to assess the biological health, perceived well-being and social well-being of cancer patients with CIPN within the scope of the biopsychosocial model. MethodsThis study was conducted in oncology clinics and outpatient clinics of a research hospital. The sample comprised 109 patients who met the following inclusion criteria: age ≥ 18 years, completed at least three cycles of taxane and platinum chemotherapy treatment, showed peripheral neuropathy symptoms, could communicate in Turkish and provided consent to participate in the study. For data collection, Patient Information Form, Chemotherapy-induced Peripheral Neuropathy Scale (EQRTC QLQ CIPN20), Perceived Well-being Scale and Social Well-being Scale were used. Results The EQRTC QLQ CIPN20 score was higher in those with high school and higher education than in those with primary school education and below. Perceived well-being was higher with the increase in age, in males, patients receiving only chemotherapy but no immunotherapy, patients without additional stressors, unemployed patients, patients receiving care support from their spouses at home and patients living with their spouses. The social well-being level was higher in those with higher age and number of treatments, those without stem cell transplantation, those without additional stressors, those with primary school education and below and those living alone. Conclusions These findings suggest that CIPN symptoms should be evaluated holistically and supportive care interventions should be developed for these patients.

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“…For both sexes, the mean age at diagnosis is well over 70 years [3][4][5]. At this age, more than 90% of patients are on chronic drug therapy for pre-existing comorbidities like hypertension, hypercholesterolemia or diabetes mellitus [6][7][8]. Apart from well-known risk factors like tobacco smoking or occupational hazards, a growing body of evidence describes chronic diseases, like hypertension or metabolic syndrome, to be of concern for UCB development [5,9].…”

Section: Introductionmentioning

confidence: 99%

The Characterization of Non-oncologic Chronic Drug Therapy in Bladder Cancer Patients and the Impact on Recurrence-Free and Cancer-Specific Survival: A Prospective Study

Strobach,

Haimerl,

Mannell

et al. 2023

JCM

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We aimed to characterize non-oncologic chronic drug therapy of bladder cancer (BC) patients and evaluate a possible impact on recurrence-free (RFS) and cancer-specific survival (CSS). Patients with a first diagnosis (FD) of BC or radical cystectomy (RC) were included in a prospective, monocentric, observational study. Drugs and medical data was assessed at start and three-monthly for 24 months. Drugs were classified by anatomical-therapeutic-chemical code (ATC). Endpoints for outcome analysis were RFS and CSS in univariate (Kaplan–Meier curves and log-rank test, Cox regression for Hazard Ratio (HR)) and multivariate (Cox regression models) analyses. Of 113 patients, 52 had FD and 78 RC. Median age was 74 and 72 years, 83% and 82% were male. Drugs of 114 ATC classes were taken by 48 (92%) FD patients (median number 4.5/IQR 2–7.5) and 73 (94%) of RC patients (median 5/IQR 2–9). In univariate analysis (log-rank test (p)/Cox regression (HR, 95% CI, p)), polypharmacy (p = 0.036/HR = 2.83, 95% CI = 1.02–7.90, p = 0.047), calcium channel blockers (p = 0.046/HR = 2.47, 95% CI = 0.97–6.27, p = 0.057) and proton pump inhibitors (p = 0.015/HR = 3.16, 95% CI = 1.18–8.41, p = 0.022) had a significant negative impact on RFS in RC patients, statins (p = 0.025/HR = 0.14, 95% CI = 0.02–1.06, p = 0.057) a positive effect on RFS in FD patients, angiotensin-converting enzyme inhibitors (p = 0.008/HR = 10.74, 95% CI = 1.20–96.17, p = 0.034) and magnesium (p = 0.042/HR = 5.28, 95% CI = 0.88–31.59, p = 0.067) a negative impact on CSS in FD patients. In multivariate analysis, the only significant drug effects were the negative impact of angiotensin-converting enzyme inhibitors (HR = 15.20, 95% CI = 1.30–177.67, p = 0.030) and magnesium (HR = 22.87, 95% CI = 1.57–333.81), p = 0.022) on CSS in FD patients, and the positive impact of statins (HR = 0.12, 95% CI = 0.01–0.97, p = 0.047) on RFS in FD patients. Impact of non-oncologic drugs on RFS and CSS was small in this prospective study. Thus, appropriate treatment of comorbidities is encouraged.

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Comorbidities and perceived health status in persons with history of cancer in the USA

Cited by 3 publications

References 26 publications

Chemotherapy-induced peripheral neuropathy according to biopsychosocial model: A descriptive cross-sectional correlational study

Chemotherapy-induced peripheral neuropathy according to biopsychosocial model: A descriptive cross-sectional correlational study

Chemotherapy-induced Peripheral Neuropathy According to Biopsychosocial Model: A Descriptive Cross-Sectional Correlational Study

The Characterization of Non-oncologic Chronic Drug Therapy in Bladder Cancer Patients and the Impact on Recurrence-Free and Cancer-Specific Survival: A Prospective Study

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