Comorbidities and Risk of Complications After Surgery for Esophageal Cancer: A Nationwide Cohort Study in Sweden

Abstract

Cardiac disease and a Charlson comorbidity index score ≥2 seem to increase the risk of severe and early post-operative complications in patients with esophageal cancer, while hypertension, pulmonary disorders, diabetes, and obesity do not. These findings should be considered in the clinical decision-making for improved selection of patients for surgery.

Long noncoding RNA HAGLR acts as a microRNA‐143‐5p sponge to regulate epithelial‐mesenchymal transition and metastatic potential in esophageal cancer by regulating LAMP3

“…Lifestyles play a distinct role in the occurrence of the disease, with reports highlighting factors such as alcohol consumption, smoking, and genetic variants leading to an increased risk of EC (4,5). Existing literature has identified surgery as one of the most conventional therapeutic avenues for patients with early-stage EC, whereas perioperative chemotherapy or chemoradiotherapy is often applied for patients with locally advanced-stage EC (6)(7)(8). However, the majority of treatment protocols are still accompanied by an unsatisfactory overall 5-yr survival rate, owing to factors such as late diagnosis, tumor invasion, and metastasis as well as the side effects and resistance encountered by certain patients in confined drugs (9)(10)(11).…”

Esofagectomía en un centro suramericano de tratamiento del cáncer

“…Además, Backemar, et al, observaron que los pacientes con hipertensión arterial, diabetes mellitus o enfermedad pulmonar (generalmente asociadas a una edad avanzada), presentaron también una mayor frecuencia de complicaciones 4,13 . Por el contrario, en un estudio reciente de Paulus, et al, se presentaron complicaciones similares en pacientes mayores de 80 años sometidos a esofagectomías, con buenos resultados.…”

“…Las complicaciones muestran cifras representativas de mortalidad (26 a 64 %), y generan un retorno tardío a las actividades, retraso del tratamiento adyuvante e incremento de costos para los sistemas de salud. Por otra parte, las fugas de las anastomosis representan una complicación particularmente seria, reportada en 3,8 a 11,7 % de los pacientes, las cuales pueden requerir manejo médico o quirúrgico según su gravedad [4][5][6] . A pesar de que el cáncer de esófago no es un problema de salud en nuestra región, como sí lo son el de estómago y el colorrectal, su aumento progresivo obliga a evaluar nuestro desempeño en el tratamiento de esta enfermedad cada vez más frecuente.…”

“…2018;33:71-78 variable (0,3 a 22 %), influenciada por la experiencia del cirujano y su práctica en centros de alto volumen de tratamiento [4][5][6] . Las complicaciones muestran cifras representativas de mortalidad (26 a 64 %), y generan un retorno tardío a las actividades, retraso del tratamiento adyuvante e incremento de costos para los sistemas de salud.…”

Decreased total psoas muscle area after neoadjuvant therapy is a predictor of increased mortality in patients undergoing oesophageal cancer resection

“…The Charlson co-morbidity index was calculated excluding points for age and solid tumour, as described in the Swedish retrospective study by Backemar et al which assessed the use of this score in oesophagectomy patients. 17 The American Society of Anesthesiologists (ASA) score was determined using the 2014 guideline. 18 The study met the New Zealand National Ethics Committee Guidelines definition of an audit and therefore did not require ethics committee review.…”