Comorbidities and Symptoms among Endometriosis Patients: A Systematic Literature Review

Soliman, AM; Yang, Hongbo; Du, E.X.; Wu, EQ; Castelli-Haley, Jane; Winkel, Craig A.

doi:10.1016/j.jval.2016.03.1445

Cited by 4 publications

(4 citation statements)

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“…The varying degrees of involvement by endometriosis resulted in symptoms of varying severity. Buchanan, 2017;Soliman et al, 2016). However, the results indicated that, in addition to causing physical symptoms, endometriosis had a significant impact on the emotional well-being of the participants, which slightly differed from the findings of other studies.…”

Section: The Associations Between Symptom Distress and H-qolmentioning

confidence: 79%

“…The varying degrees of involvement by endometriosis resulted in symptoms of varying severity. Common symptoms include abnormal uterine bleeding, menorrhagia, pelvic pain, abnormal intestinal function, frequent or urgent urination, lower back pain, and dyspareunia (De La Cruz & Buchanan, 2017; Soliman et al, 2016). However, the results indicated that, in addition to causing physical symptoms, endometriosis had a significant impact on the emotional well‐being of the participants, which slightly differed from the findings of other studies.…”

Section: Discussionmentioning

confidence: 99%

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Factors influencing health‐related quality of life in women with endometriosis: A cross‐sectional study

Wu,

Lu,

Liu

2024

Nursing & Health Sciences

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This study aimed to assess the health‐related quality of life and identify its associated factors in women with endometriosis. A cross‐sectional correlation study design and convenience sampling were conducted in the gynecological outpatient clinic of a teaching hospital in northern Taiwan. A total of 216 women with endometriosis were recruited. The data were collected using structured questionnaires and analyzed using descriptive and inferential statistics. Participants reported a moderate level of health‐related quality of life. The most significant impact of endometriosis on health‐related quality of life was emotional well‐being, followed by feeling of control or powerless, pain, social support, and self‐image. Educational attainment, menstrual cycle, period length, perceived menstrual flow, symptom distress, and self‐management strategies explained 66% of the variance in health‐related quality of life. Factors influencing health‐related quality of life in women with endometriosis play a key role in promoting women's well‐being. Interventions based on these related factors should be developed and taken into practice to effectively manage the disease‐related symptoms for women with endometriosis and thereby improve their overall health‐related quality of life.

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Section: The Associations Between Symptom Distress and H-qolmentioning

confidence: 79%

Section: Discussionmentioning

confidence: 99%

Factors influencing health‐related quality of life in women with endometriosis: A cross‐sectional study

Wu,

Lu,

Liu

2024

Nursing & Health Sciences

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“…A set of 22 comorbid chronic conditions that frequently co-occur with endometriosis was selected from a published literature review and reviewed by a clinical expert (Dr. Craig A. Winkel, MD) [ 17 ]. The set includes comorbidities related to gynecological, mental health, gastrointestinal, cancer, and autoimmune conditions (Online Supplementary Material, Table S.1).…”

Section: Methodsmentioning

confidence: 99%

Changes in Healthcare Spending After Diagnosis of Comorbidities Among Endometriosis Patients: A Difference-in-Differences Analysis

Epstein¹,

Soliman

Davis³

et al. 2017

Adv Ther

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IntroductionWe sought to characterize changes in healthcare spending associated with the onset of 22 endometriosis-related comorbidities.MethodsWomen aged 18–49 years with endometriosis (N = 180,278) were extracted from 2006–2015 de-identified Clinformatics® DataMart claims data. For 22 comorbidities, comorbidity patients were identified on the basis of having a first comorbidity diagnosis after their initial endometriosis diagnosis. Controls were identified on the basis of having no comorbidity diagnosis and were matched 1:1 to comorbidity patients on demographics and baseline spending. Total medical and pharmacy spending was measured during 12 months before and after each patient’s index date (first comorbidity diagnosis for comorbidity patients, and equal number of days after earliest endometriosis claim for controls). Pre–post spending differences were compared using difference-in-differences linear regression. Total and comorbidity-related cumulative spending per patient for all endometriosis patients were calculated annually for the 5 years following endometriosis diagnosis.ResultsThe number of endometriosis patients with each comorbidity varied between 121 for endometrial cancer and 16,177 for fatigue. Healthcare spending increased significantly with the onset of eight comorbidities: breast cancer, ovarian cancer, pregnancy complications, systemic lupus erythematosus/rheumatoid arthritis/Sjogren’s/multiple sclerosis, infertility, uterine fibroids, ovarian cyst, and headache [p < 0.001 except for headache (p = 0.045)]. Spending decreased significantly for fatigue, cystitis/UTI, and eczema [p < 0.001 except for fatigue (p = 0.048)] and was not statistically different for the other 11 comorbidities. Difference-in-differences estimates were significantly higher for comorbidity patients for all comorbidities except eczema (p ≤ 0.003). Mean 5-year total cumulative spending was $58,191 per endometriosis patient, of which between 11% and 23% was attributable to comorbidity-related medical claims.ConclusionFor all but one of the 22 comorbidities associated with endometriosis, comorbidity onset was associated with a relative increase in total healthcare spending.FundingAbbVie Inc.Electronic supplementary materialThe online version of this article (doi:10.1007/s12325-017-0630-8) contains supplementary material, which is available to authorized users.

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“…Recent studies have revealed a higher prevalence of allergies and autoimmune diseases in patients with endometriosis 10 – 12 . However, the relationship between endometriosis and SLE has not been studied thoroughly and remains unclear.…”

Section: Introductionmentioning

confidence: 99%

Association between endometriosis and risk of systemic lupus erythematosus

Fan

Leong

Chiou

et al. 2021

Sci Rep

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To examine the association between endometriosis and the risk of systemic lupus erythematosus (SLE), this nationwide, population-based, retrospective cohort study was conducted based on National Health Insurance Research Database in Taiwan. Endometriosis (N = 16,758) and non-endometriosis (N = 16,758) groups were identified by matching baseline characteristics and comorbidities. Student’s t-tests and the Kaplan–Meier estimator were utilized to estimate the hazard ratio (HR) and cumulative probability of SLE in the two groups. The endometriosis group showed a significantly higher incidence density rate (0.3 vs. 0.1 per 1000 person-years) and hazard ratio in SLE group (adjusted HR [aHR], 2.37; 95% confidence interval [CI] 1.35–4.14) compared to the non-endometriosis group. Subgroup analysis revealed that patients with endometriosis between 30 and 45 years of age, or were non-steroidal anti-inflammatory drug users, or were hormonal medications-free participants, had higher risks of SLE. For patients with endometriosis, surgical intervention did not significantly impact on the risk of SLE. Our results demonstrated an increased risk of SLE in patients with endometriosis. Clinicians should be aware of this association when managing patients with endometriosis or SLE.

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Comorbidities and Symptoms among Endometriosis Patients: A Systematic Literature Review

Cited by 4 publications

References 0 publications

Factors influencing health‐related quality of life in women with endometriosis: A cross‐sectional study

Factors influencing health‐related quality of life in women with endometriosis: A cross‐sectional study

Changes in Healthcare Spending After Diagnosis of Comorbidities Among Endometriosis Patients: A Difference-in-Differences Analysis

Association between endometriosis and risk of systemic lupus erythematosus

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