Comorbidities in Anti-Cyclic Citrullinated Peptide Positive At-Risk Individuals Do Not Differ from Those Patients with Early Inflammatory Arthritis

Abstract

ObjectivesTo compare comorbidities in a cohort of cyclic citrullinated peptide (CCP) antibody positive patients without or prior to onset of inflammatory arthritis (IA) to those in patients with early IA.MethodsBaseline data from two established cohorts were used. The first recruited people at risk of IA: CCP antibody positive cases without IA (CCP Cohort, n = 296). The second cohort [the Inflammatory Arthritis CONtinuum study (IACON)] recruited patients with early IA (n = 725). Proportions of patients with given comorbidities were compared between cohorts and then logistic regression was used to determine odds ratios (OR) for the CCP cohort having specific comorbidities, compared to IACON patients. Analyses adjusted for gender, age, smoking status, and body mass index.ResultsPatients from the CCP cohort were younger (mean age 50, compared to 53 years). The proportion of patients with at least one comorbidity was higher in the IACON than the CCP cohort: (40% compared to 24%, respectively). Results of logistic regression analyses suggested the odds of hypertension, taking a lipid-lowering agent, ischemic heart disease, cerebrovascular disease, lung disease, and diabetes were not increased in either cohort. However, patients in the CCP cohort were more likely to be taking an antidepressant (OR = 1.62, 95% CI 1.03, 2.56, p = 0.037).ConclusionThere was no significant difference in comorbidities among people with CCP antibodies but without IA, compared to those of patients with established IA.

Rheumatoid arthritis: Extra-articular manifestations and comorbidities

“…Moreover, ACPA is associated with a more aggressive RA course and with EMs [24]. A recent study by Twigg et al on more than a thousand RA patients demonstrated that the comorbidities in ACPA-positive patients without inflammatory arthritis are the same as patients with early inflammatory arthritis [25]. This suggests that comorbidities in ACPA-positive patients may begin to appear before the onset of clinical signs of inflammation.…”

“…This suggests that comorbidities in ACPA-positive patients may begin to appear before the onset of clinical signs of inflammation. In particular, ACPA positivity contributes to the development of CVD [25] and may induce subclinical atherosclerotic damage [26].…”

Peculiarities of Diagnostics of Diastolic Form of Cardiac Insufficiency in Patients With Anti-CCP Positive Rheumatoid Arthritis

“…Ранее было доказано, что антитела к циклическому цитруллинированному пептиду (АЦЦП) связаны с более высокой частотой внесуставных проявлений и худшими исходами, а также с патогенезом сердечнососудистой недостаточности [2,3] и развитием диастолической дисфункции левого желудочка (ДДЛЖ) [5,8] при РА. Наряду с этим было отмечено, что желудочковая дисфункция связана с более длительной продолжительностью заболевания и повышенными серологическими маркерами ревматоидного артрита [4].…”