Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers

Singh, Awadhesh Kumar; Gupta, Ritesh; Misra, Anoop

doi:10.1016/j.dsx.2020.03.016

Cited by 222 publications

(216 citation statements)

References 40 publications

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“…The emerging data on COVID-19 pandemic clearly identify that the presence of comorbidities (ie, diabetes, hypertension, cardiac disease, and pulmonary disease) are responsible for a significantly greater risk of mortality. 9 Similarly, chronic diseases have been identified to be more common in patients with OPMDs; for instance, dyslipidemia and asthma have been identified as being more prevalent in patients with oral leukoplakia in comparison to case-controls. 10 Furthermore, elderly patients (≥75 years of age) who develop oral leukoplakia have a higher 5-year cumulative incidence (3.21%) for the development of oral cancer.…”

Section: Considerations For the Evaluation Of New And Established Pmentioning

confidence: 99%

Considerations in the evaluation and management of oral potentially malignant disorders during the COVID‐19 pandemic

et al. 2020

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Aim: The COVID-19 pandemic has resulted in society experiencing unprecedented challenges for health care practitioners and facilities serving at the frontlines of this pandemic. With regard to oral cancer, there is a complete absence of literature regarding the long-term impact of pandemics on patients with oral potentially malignant disorders (OPMDs). The objective of this article is to put forth an institutional multidisciplinary approach for the evaluation and management of OPMDs. Methods: A multidisciplinary approach was put formalized within our institution to risk stratify patients based on need for in-person assessment vs telehealth assessment during the COVID-19 pandemic. Results: With judicious risk stratification of patients based on clinical features of their OPMD and with consideration of ongoing mitigation efforts and regional pandemic impact, providers are able to safely care for their patients. Conclusions:The COVID-19 pandemic has required health care practitioners to make novel decisions that are new to us with development of creative pathways of care that focused on patient safety, mitigation efforts, and clinical management of disease processes. The care of patients with OPMDs requires special considerations especially as patients at high risk for severe illness are also higher risk for the development of OPMDs.

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Section: Considerations For the Evaluation Of New And Established Pmentioning

confidence: 99%

Considerations in the evaluation and management of oral potentially malignant disorders during the COVID‐19 pandemic

et al. 2020

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“…This association of blood fat levels with in ammaging becomes even more serious when we consider that the presence of cardiovascular disease is associated with a worse prognosis and mortality for COVID-19 47 . In practical terms, a study by 48 reported an almost two-fold increase in mortality in patients with cardiovascular disease.…”

Section: Discussionmentioning

confidence: 99%

“…With regard to the relationship between in amm-aging and COVID-19, we can highlight that understanding this in ammatory condition is fundamental for the identi cation of elderly people with a higher risk of mortality if they are exposed to the virus. The scienti c community 47,49,50 has proposed that the course of treatment and prognosis of COVID-19 should be strati ed according to the presence or absence of comorbidities prior to SARS-COV-2 infection. Thus, those patients who have acute respiratory failure syndrome (SIRA), a characteristic symptom of COVID-19 but do not have any comorbidities, are strati ed into TYPE A patients.…”

Section: Discussionmentioning

confidence: 99%

Inflammaging: Analysis of a Risk Profile for Gerontocide by COVID-19 in Brazil

Neto¹,

Tavares²,

Agrícola³

et al. 2020

Preprint

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Introduction: The increase in inflammatory cytokines associated with a reduction in the bioavailability of zinc has been used as a marker for inflammation. Despite the high inflammatory state found in institutionalized elderly individuals, few studies have proposed verifying the factors associated with this condition in this population to pandemic COVID-19.Objective: To verify the factors associated with inflamm-aging in institutionalized elderly.Methodology: A total of 187 elderly individuals (≥ 60 years old) living in the nursing homes of Natal/RN were included in the study. After cluster analysis was used to identify 3 groups according to their inflammatory state, an analysis of sarcopenia and anthropometric, biochemical, sociodemographic and health-related variables was performed. In sequence, an ordinal logistic regression was performed for a confidence level of 95% in those variables with p <0.20 in the bivariate analysis.Results: IL-6, TNFα and Zinc. Low-density lipids (LDL), high-density lipids (HDL) and triglycerides were associated with inflamm-aging. The increase of 1 unit of measurement of LDL, HDL and triglycerides increased the chance of inflammation-aging by 1.5%, 4.1% and 0.9%, respectively, while oldest old (≥80 years old) had 84.9% chance of presenting inflamm-aging in relation to no oldest old (<80 years).Conclusion: The association between biochemical markers and inflamm-aging demonstrates a relationship between endothelial injury and the inflammatory state. In addition, the presence of a greater amount of fat in the blood may present a higher relative risk of death from COVID-19.

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“…Indeed, while most of the patients show only a mild-moderate form of the disease, around 10-15% of patients suffer from a more aggressive form of the disease presented as severe to critical symptoms [4]. Many reports highlight that patients with specific comorbidities are more susceptible to the critical form of the disease compared to the general population [5]. Therefore, further investigations and early identification of those subgroups might be essential to improve the outcome of these vulnerable patients.…”

Section: Introductionmentioning

confidence: 99%

Cellular exocytosis gene (EXOC6/6B): a potential molecular link for the susceptibility and mortality of COVID-19 in diabetic patients

Hachim

Heialy

et al. 2020

Preprint

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Diabetes is one of the most critical comorbidities linked to an increased risk of severe complications in the current coronavirus disease 2019 (COVID-19) pandemic. A better molecular understanding of COVID-19 in people with type diabetes mellitus (T2D) is mandatory, especially in countries with a high rate of T2D, such as the United Arab Emirates (UAE). Identification of the cellular and molecular mechanisms that make T2D patients prone to aggressive course of the disease can help in the discovery of novel biomarkers and therapeutic targets to improve our response to the disease pandemic. Herein, we employed a system genetics approach to explore potential genomic, transcriptomic alterations in genes specific to lung and pancreas tissues, affected by SARS-CoV-2 infection, and study their association with susceptibility to T2D in Emirati patients. Our results identified the Exocyst complex component, 6 (EXOC6/6B) gene (a component for docks insulin granules to the plasma membrane) with documented INDEL in 3 of 4 whole genome sequenced Emirati diabetic patients. Publically available transcriptomic data showed that lung infected with SARS-CoV-2 showed significantly lower expression of EXOC6/6B compared to healthy lungs.In conclusion, our data suggest that EXOC6/6B might be an important molecular link between dysfunctional pancreatic islets and ciliated lung epithelium that makes diabetic patients more susceptible to severe SARS-COV-2 complication.

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Comorbidities in COVID-19: Outcomes in hypertensive cohort and controversies with renin angiotensin system blockers

Cited by 222 publications

References 40 publications

Considerations in the evaluation and management of oral potentially malignant disorders during the COVID‐19 pandemic

Considerations in the evaluation and management of oral potentially malignant disorders during the COVID‐19 pandemic

Inflammaging: Analysis of a Risk Profile for Gerontocide by COVID-19 in Brazil

Cellular exocytosis gene (EXOC6/6B): a potential molecular link for the susceptibility and mortality of COVID-19 in diabetic patients

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