Comorbidities, multimorbidity and COVID-19

Russell, Clark D; Lone, Nazir; Baillie, J Kenneth

doi:10.1038/s41591-022-02156-9

Cited by 197 publications

(143 citation statements)

References 96 publications

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“…It is therefore unclear as to why females appear to be a risk group for substantial sick leave following acute SARS-CoV-2 infection but males are not. Further research examining age-sex interactions and the impact of multimorbidity on long covid outcomes are needed (35).…”

Section: Other Risk Factorsmentioning

confidence: 99%

Covid-19 and post-acute sick leave: a hybrid register and questionnaire study in the adult Danish population

O'Regan

Svalgaard

Sørensen

et al. 2023

Preprint

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Long covid follows 10-20% of first-time SARS-CoV-2 infections, but the societal burden of long covid and risk factors for the condition are not well-understood. Here, we report findings about self-reported sick leave and risk factors thereof from a hybrid survey and register study, which included 37,482 RT-PCR confirmed SARS-CoV-2 cases and 51,336 test-negative controls who were tested during the index and alpha waves. An additional 33 individuals per 1000 took substantial sick leave following acute infection compared to persons with no known history of infection, where substantial sick leave was defined as >1 month of sick leave within the period 1-9 months after the RT-PCR test date. Being female, ≥50 years, and having certain pre-existing conditions such as fibromyalgia increased risks for taking substantial sick leave. Further research exploring this heterogeneity is urgently needed and may provide important evidence for more targeted preventative strategies.

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Section: Other Risk Factorsmentioning

confidence: 99%

Covid-19 and post-acute sick leave: a hybrid register and questionnaire study in the adult Danish population

O'Regan

Svalgaard

Sørensen

et al. 2023

Preprint

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“…Despite vaccination, less virulent variants and evidence-based treatments, COVID-19 continues to be an important cause of disability, especially for people with weakened immune responses 6 . Thus, there remains an important need for interventions which benefit hospitalized patients.…”

Section: Discussionmentioning

confidence: 99%

“…Beyond supportive measures, treatment in the hyperinflammatory phase of COVID-19 consists of corticosteroids 3 , interleukin 6 4 (IL- 6) and Janus kinase 5 (JAK) inhibitors. Despite the benefit of these therapies, elderly and immunocompromised persons remain at risk for serious complications, even in the context of vaccination and less virulent variants 6 . Thus, more effective treatments could improve outcome and prevent long-term sequalae.…”

Section: Introductionmentioning

confidence: 99%

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Damme

Hoste

Declercq

et al. 2023

Preprint

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To improve COVID-19 therapy, it is essential to understand the mechanisms driving critical illness. The complement system is an essential part of innate host defense that can also contribute to injury. All complement pathways have been implicated in COVID-19 pathogenesis, however the upstream drivers and downstream consequences on tissue injury remain ill-defined. Here, we demonstrate that complement activation is mediated by the alternative pathway and we provide a comprehensive atlas of the alterations in complement around the time of respiratory deterioration. Proteome and single-cell sequencing mapping across cell types and tissues reveals a division of labor between lung epithelial, stromal and myeloid cells in the production of complement, in addition to liver-derived factors. Upstream, IL-6 drives complement responses, linking complement dysregulation to approved COVID-19 therapies. In an exploratory proteomic study, C5 inhibition improves epithelial damage and markers of disease severity. Collectively, these results identify complement dysregulation as a key druggable feature of COVID-19.

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“…The deleterious effects of DM and long COVID on the cardiovascular system are additive [5] . Firstly, long COVID may impair cardiorespiratory fitness.…”

Section: Introductionmentioning

confidence: 99%

Repurposing exercise training and pharmacological therapies to address the post-acute sequelae of COVID-19 (PASC) in diabetes mellitus

Chee

Dalan

2023

Diabetes Research and Clinical Practice

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Comorbidities, multimorbidity and COVID-19

Cited by 197 publications

References 96 publications

Covid-19 and post-acute sick leave: a hybrid register and questionnaire study in the adult Danish population

Covid-19 and post-acute sick leave: a hybrid register and questionnaire study in the adult Danish population

A Complement Atlas identifies interleukin 6 dependent alternative pathway dysregulation as a key druggable feature of COVID-19

Repurposing exercise training and pharmacological therapies to address the post-acute sequelae of COVID-19 (PASC) in diabetes mellitus

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