Comorbidities of bullous pemphigoid in a Finnish cohort

Pankakoski, Anna; Sintonen, Harri; Ranki, Annamari; Kluger, Nicolas

doi:10.1684/ejd.2018.3243

Cited by 33 publications

(41 citation statements)

References 23 publications

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“…As for diagnosis, we examined DIF results of 229 DIBP patients discussed in two retrospective case-control studies and in 42 case reports, and found 186 DIF positive patients, 15 DIF negative, and 28 with an unclear DIF result. Although in the literature some reviews and retrospective case-control studies do not always report DIF results, in the vast majority of DIBP patients, the diagnosis was obtained through the gold standard approach: DIF [ 9 , 10 , 11 , 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 , 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 ].…”

Section: Trigger Factorsmentioning

confidence: 99%

Bullous Pemphigoid: Trigger and Predisposing Factors

et al. 2020

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Bullous pemphigoid (BP) is the most frequent autoimmune subepidermal blistering disease provoked by autoantibodies directed against two hemidesmosomal proteins: BP180 and BP230. Its pathogenesis depends on the interaction between predisposing factors, such as human leukocyte antigen (HLA) genes, comorbidities, aging, and trigger factors. Several trigger factors, such as drugs, thermal or electrical burns, surgical procedures, trauma, ultraviolet irradiation, radiotherapy, chemical preparations, transplants, and infections may induce or exacerbate BP disease. Identification of predisposing and trigger factors can increase the understanding of BP pathogenesis. Furthermore, an accurate anamnesis focused on the recognition of a possible trigger factor can improve prognosis by promptly removing it.

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Section: Trigger Factorsmentioning

confidence: 99%

Bullous Pemphigoid: Trigger and Predisposing Factors

et al. 2020

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“…We did not find higher rates of malignancy in our BP patients compared with controls. Studies that cite higher rates of cancer may fail to account for age, which alone could explain a heightened cancer risk [2][3][4]. Our patient cohort adds to the mounting evidence that most cases of BP are not associated with underlying malignancy.…”

Section: Discussion/conclusionmentioning

confidence: 91%

“…It is the most common autoimmune blistering disease and has an estimated incidence of up to 14 new cases per million per year, mainly affecting the elderly [1]. The association between BP and malignancies remains unclear as some studies have cited a higher rate of malignancy in patients with BP [2][3][4], whereas other studies have stated that there is no such association [5,6]. The most common treatment for BP is systemic and/or topical glucocorticoids.…”

Section: Introductionmentioning

confidence: 99%

Bullous Pemphigoid and Malignancy in Two Different Hospital Populations: A Retrospective Cohort Review

2020

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Background: Bullous pemphigoid (BP) is a rare autoimmune blistering condition characterized by antibodies to the structural proteins BP1 and BP2 at the dermal-epidermal junction. The link between BP and malignancy remains unclear. Due to the rarity of the disease, there have been few studies with small sample sizes characterizing the association between BP and malignancy. Objectives: There were two main goals of this retrospective cohort study: (1) to look at the associated risk of malignancy in patients with BP compared to controls and (2) to compare the rates of malignancy in two separate hospitals with differing patient populations. Method: We reviewed the medical records of 99 patients diagnosed with BP observed between 2014 and 2019. 66 patients were from Keck Hospital and 33 were from Los Angeles County/ University of Southern California (LAC/USC) Hospital. Each patient was age-and sex-matched to a control from the same hospital. Results: Malignancies occurred in 26 BP patients and 29 controls. 7 of the BP patients from LAC/USC Hospital (21.2%) and 19 patients from Keck Hospital (28.8%) had malignancies. Conclusions: Overall, we did not find an increased risk of malignancy in BP patients compared to controls, nor did we find a statistically differing rate of malignancy in BP patients from various socioeconomic and ethnic backgrounds.

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“…The latter is methodologically valid in large data analyses and was found to reliably predict mortality. Since both investigated diseases are implicated with an increased prevalence of metabolic outcomes ( 16 , 17 ), we have additionally adjusted for body mass index (BMI), the presence of diabetes mellitus, hypertension, dyslipidemia, and smoking. These variables were retrieved from the chronic registry of CHS.…”

Section: Methodsmentioning

confidence: 99%

The Bidirectional Association Between Bullous Pemphigoid and Psoriasis: A Population-Based Cohort Study

et al. 2020

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The risk of developing psoriasis during the course of bullous pemphigoid (BP) is yet to be investigated. We aimed to assess the risk of psoriasis among patients with BP and the risk of BP in individuals with a history of psoriasis. A population-based retrospective cohort study was conducted comparing BP patients ( n = 3,924) with age-, sex-, and ethnicity-matched control subjects ( n = 19,280) with regard to incident cases of psoriasis. A case-control design was additionally followed to estimate the risk of BP in those with a preceding diagnosis of psoriasis. Adjusted hazard ratios (HRs) and adjusted odds ratios (ORs) were estimated by Cox regression and logistic regression, respectively. The incidence of psoriasis was 1.78 (95% CI, 1.25–2.48) and 0.67 (95%CI, 0.53–0.83) per 1,000 person-years among patients with BP and controls, respectively. Patients with BP were 2.6-fold more likely to develop psoriasis (HR, 2.60; 95%CI, 1.59–4.27) compared to controls. Furthermore, the prevalence of preexisting psoriasis was higher in patients with BP than in control subjects (1.7 vs. 1.1%, respectively; P < 0.001). A history of psoriasis was associated with a 50% increase in the risk of BP (OR, 1.53; 95%CI, 1.17–2.02). Patients with a dual diagnosis of BP and psoriasis were younger, had higher prevalence of smoking and hypertension, and were treated more frequently with prolonged systemic and topical corticosteroids when compared to the remaining patients with BP. To conclude, a bidirectional association exists between BP and psoriasis. Awareness of this association may be of great importance for physicians managing patients with BP and psoriasis.

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Comorbidities of bullous pemphigoid in a Finnish cohort

Cited by 33 publications

References 23 publications

Bullous Pemphigoid: Trigger and Predisposing Factors

Bullous Pemphigoid: Trigger and Predisposing Factors

Bullous Pemphigoid and Malignancy in Two Different Hospital Populations: A Retrospective Cohort Review

The Bidirectional Association Between Bullous Pemphigoid and Psoriasis: A Population-Based Cohort Study

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