Comorbidities of hidradenitis suppurativa: A review of the literature

Cartron, Alexander M; Driscoll, Marcia S.

doi:10.1016/j.ijwd.2019.06.026

Cited by 46 publications

(31 citation statements)

References 43 publications

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“…Interestingly, a Danish cross-sectional study showed that the mean heart rate in severe HS patients in resting conditions was suggestively higher when compared with that of controls [ 17 ]. Both HS and atherosclerosis have a chronic inflammatory subset, and cardiovascular and metabolic diseases are the most common comorbidities found in HS [ 18 , 19 ]. Atherosclerosis, a chronic inflammatory disease affecting the blood vessels, is considered a major cause of cardiovascular diseases.…”

Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiovascular Risk in Hidradenitis Suppurativa Patients Using Heart Rate Variability (HRV) Analysis

Skroza

Mambrin

Proietti

et al. 2020

Cardiovascular Therapeutics

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Hidradenitis suppurativa (HS) is a chronic inflammatory skin disease associated with elevated prevalence of comorbidities, especially metabolic and cardiovascular diseases. We used a tool called Heart Rate Variability (HRV) in order to assess the correlation between HS and alterations of the sympathetic-vagal equilibrium in the autonomic cardiovascular regulation system. We found increased sympathetic activity, associated with a higher risk of cardiovascular disease. HS, according to our results, is an independent cardiovascular risk factor.

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Section: Discussionmentioning

confidence: 99%

Evaluation of Cardiovascular Risk in Hidradenitis Suppurativa Patients Using Heart Rate Variability (HRV) Analysis

Skroza

Mambrin

Proietti

et al. 2020

Cardiovascular Therapeutics

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“…Patients with psoriasis and hidradenitis suppurativa have increased the prevalence of cardiovascular risk factors, myocardial infarction, and mortality. [1][2][3][4][5][6] In addition, patients with psoriasis, acne, hidradenitis suppurativa, and alopecia areata are at an increased risk of mental health comorbidities, such as anxiety, depression, and suicidality. [7][8][9][10] While management of these comorbidities is often done by primary care providers, for some patients, their dermatologist may be their only point of contact with the health care system.…”

Section: Introductionmentioning

confidence: 99%

Use of primary care services among patients with chronic skin disease seen by dermatologists

et al. 2021

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Background: Skin diseases, such as psoriasis, hidradenitis suppurativa, acne, and alopecia areata, have increasingly been linked to systemic and mental health comorbidities, such as depression. Although identification and management of these comorbidities is typically a part of primary care, some patients might not have an established relationship with a primary care provider and may only be seeing their dermatologist. Objective: To examine the frequency with which dermatologists are the main contact within a health care system for patients with these chronic skin conditions. Methods: We performed a retrospective cohort study using Optum's deidentified Clinformatics Data Mart Database. The primary outcome was the proportion of patients who established care with a dermatologist and had no encounters with a primary care provider during the subsequent year after this dermatology encounter. Results: Across each of the skin diseases evaluated, 21.6%-31.2% of men and 16.9%-26.2% of women had no primary care visits in the subsequent year after establishing care with their dermatologist. Conclusion and Relevance: For many patients with chronic skin diseases, their dermatologist might be their only source of contact with the health care system. There may be an opportunity for dermatologists to improve the quality of care for our patients by screening for associated comorbidities.

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“…Prevalence of HS varies from 0.05% to 4.1% 2 and it's more commonly seen in females 3 . HS has a significant burden of comorbidities beyond the skin, including metabolic, cardiovascular, endocrine, gastrointestinal, rheumatologic, and psychiatric disorders, which all decrease the quality of life 4 …”

Section: Introductionmentioning

confidence: 99%

Evaluation of the laboratory parameters in hidradenitis suppurativa: Can we use new inflammatory biomarkers?

Çetinarslan¹,

Ermertcan

Özyurt

et al. 2021

Dermatologic Therapy

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Hidradenitis suppurativa (HS) is a chronic, recurrent, and debilitating skin disease.Recent studies showed that inflammatory biomarkers, such as neutrophil-lymphocyte ratio (NLR), platelet-lymphocyte ratio (PLR), Lymphocyte/HDL ratio (LHR), Neutrophil/HDL ratio (NHR), and Monocyte/HDL ratio (MHR) are an indicator of inflammatory diseases and may be associated with disease severity and disease activity. To investigate NLR, PLR, LHR, NHR, and MHR in HS patients. In addition, to compare erythrocyte sedimentation rate (ESR), C-reactive protein (CRP), complete blood count, leukocyte profile, and biochemical parameters between the control and the patient group. Clinical and biochemical data of patients and healthy subjects were collected from medical records, retrospectively. In total, 166 patients with HS and 124 control subjects were included. We found no significant difference in NLR (P = .207) and PLR (P = .257). LHR (P < .001), NHR (P < .001), and MHR (P < .001) were significantly higher in the patient group. No positive correlation was found between any of these markers and disease severity according to Hurley staging system. However, MCV (Mean corpuscular volume), RDW (Red cell distribution width), and CRP showed a significant positive correlation with disease severity. Among these markers, only MHR was positively correlated with disease duration. Our study shows that CRP still maintains its value for HS patients compared to new inflammation markers. Unlike the studies in other inflammatory diseases, no significant relationship was found with most of these inflammatory parameters. MHR may be more useful in patients with HS as an indicator of inflammation compared to other parameters.

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Comorbidities of hidradenitis suppurativa: A review of the literature

Cited by 46 publications

References 43 publications

Evaluation of Cardiovascular Risk in Hidradenitis Suppurativa Patients Using Heart Rate Variability (HRV) Analysis

Evaluation of Cardiovascular Risk in Hidradenitis Suppurativa Patients Using Heart Rate Variability (HRV) Analysis

Use of primary care services among patients with chronic skin disease seen by dermatologists

Evaluation of the laboratory parameters in hidradenitis suppurativa: Can we use new inflammatory biomarkers?

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