“…Most previous studies of comorbidity in SCCHN used either a cross-sectional approach 8,9 or defined comorbidities using a composite comorbidity index. 8,[10][11][12][13][14][15] As a result, limited quantitative data exist to describe the burden of distinct comorbid illnesses diagnosed prior to SCCHN or that arise during the treatment phase. Therefore, a longitudinal study was conducted among a population-based cohort of patients with SCCHN to assess the prevalence and incidence of comorbidities, including cardiovascular diseases, asthma/chronic obstructive pulmonary disease (COPD), liver disease, diabetes, anemia, pneumonia, depression, and other malignant disease, and to compare these rates with those observed in a matched noncancer control population.…”