Comorbidity and Suicidality in Patients Diagnosed With Panic Disorder/Agoraphobia and Major Depression

Batinić, Bojan; Opačić, Goran; Ignjatov, Tijana; Baldwin, David S.

doi:10.24869/psyd.2017.186

Cited by 12 publications

(10 citation statements)

References 31 publications

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“…Pharmacotherapy and psychotherapy should also be taking these points into consideration and an effort to verify the severities of both panic and comorbid depression should be made. These results are comparable with previous studies, although some have found greater panic severity with greater depression [11][12][13] severity.…”

Section: Discussionsupporting

confidence: 91%

Assessment of Severity of Panic Disorder with co-morbid Depression and quality of life

Abhishek¹,

Mt²,

Nayok³

et al. 2019

RJMAHS

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Background: Panic disorder alone or when co-morbid with depression can severely affect the functioning of an individual. Aim: To determine the occurrence of panic disorder and co-morbid depression and their quality of life. Material and Methods: Thirty patients from psychiatry ward and out-patient department were assessed by Panic Disorder Severity Scale, Hamilton Depression Rating Scale and World Health Organization Quality Of Life for severity of panic attacks, co-morbid depression and life quality. Results: Most patients showed moderate (56.6%) to slight (36.6%) severity of panic symptoms. Of them,80% had depression. In them, 33.3% had mild and 26.6% moderate levels of depression. Quality of life was moderate in 40% and poor in 36.66%. Conclusion: Patients with panic disorder have high frequency of co-morbid depression, however severity of both needs to be assessed separately. Those who have higher severity of both or depression have poor life quality.

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Section: Discussionsupporting

confidence: 91%

Assessment of Severity of Panic Disorder with co-morbid Depression and quality of life

Abhishek¹,

Mt²,

Nayok³

et al. 2019

RJMAHS

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“…The possible explanation for the differences between the cited and our study is the interference of additional phenomena on the PD-depression comorbidity such as the maternal separation during neonatal age of the animals. Nevertheless, our results are more congruent with clinical findings [18, 19, 34, 35]. …”

Section: Discussionsupporting

confidence: 91%

“…With regard to the presence of despair-like behavior after DPAG stimulations, the comorbidity between PD and depression, independent of epilepsy, has been well established [18, 19, 34, 35]. However, experimental studies of PLB and depression comorbidity are scarce.…”

Section: Discussionmentioning

confidence: 99%

Kindling epileptogenesis and panic-like behavior: Their bidirectional connection and contribution to epilepsy-associated depression

Medel-Matus

Shin

Sankar

et al. 2017

Epilepsy & Behavior

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Anxiety is one of the most common comorbidities of epilepsy, which has major detrimental effects on the quality of life. Generalized anxiety disorder (GAD) associated with epilepsy has been receiving most attention. However, several other forms of anxiety reportedly present in epilepsy patients, including panic disorder (PD). In this study, using an animal model of limbic epilepsy, we examined the interplay between epilepsy and panic-like behavior (PLB). Further, considering the high degree of comorbidity between depression on the one hand, and both epilepsy and PD on the other hand, we studied whether and how the presence of PLB in animals with epilepsy would affect their performance in depression-relevant tests. Fifty-day-old male Wistar rats were subjected to repeated alternating electrical stimulations of the basolateral amygdala (BLA) to induce kindling of limbic seizures, and the dorsal periaqueductal gray (DPAG) to induce panic-like episodes. Seizure susceptibility and panic reaction threshold were examined before the first and 24 hours after the last stimulation. At the end of the stimulations, the rats were examined in depression-relevant tests: saccharin preference test (SPT) for anhedonia and forced swimming test (FST) for despair/hopelessness. With regard to kindling, BLA+DPAG stimulation induced more profound increase of seizure susceptibility than BLA stimulation alone (evident as the reduction of the afterdischarge threshold and the increase of the afterdischarge duration). With regard to PLB, the BLA+DPAG stimulation exacerbated the severity of panic-like episodes, as compared with the DPAG stimulation alone. BLA stimulation alone had no effects on panic-like reactions, and DPAG stimulation alone did not modify kindling epileptogenesis. Combined stimulation of BLA and DPAG induced depressive-like behavioral impairments. This is the first experimental study showing bidirectional, mutually exacerbating effect of epilepsy and PLB, and the precipitation of depressive-like state by the epilepsy-PLB comorbidity.

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“…Nevertheless, dopamine dysfunction is not sufficient to explain the psychopathology of schizophrenia and its treatment [7,8] . In addition to positive symptoms such as hallucinations and delusions which are nowadays linked with the striatal dopamine D 2 receptor overactivation resulting from hyperactive mesolimbic dopamine projections [1] many schizophrenia patients experience negative symptoms (e. g. anhedonia or social withdrawal) and cognitive impairment (e. g. working memory disturbances) [9] . Negative and cognitive symptoms may result from the prefrontal cortex dopamine D 1 receptor hypostimulation due to diminished mesocortical dopamine projections [1] .…”

Section: Introductionmentioning

confidence: 99%

“…[7,8] In addition to positive symptoms such as hallucinations and delusions which are nowadays linked with the striatal dopamine D 2 receptor overactivation resulting from hyperactive mesolimbic dopamine projections [1] many schizophrenia patients experience negative symptoms (e. g. anhedonia or social withdrawal) and cognitive impairment (e. g. working memory disturbances). [9] Negative and cognitive symptoms may result from the prefrontal cortex dopamine D 1 receptor hypostimulation due to diminished mesocortical dopamine projections. [1] It should be emphasized, however, that even current aberrant salience hypothesis [10] which is the most recent version of the dopaminergic hypothesis of schizophrenia is not able to reflect the complex clinical picture of the disease.…”

Section: Introductionmentioning

confidence: 99%

Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety

et al. 2022

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Schizophrenia is a complex disease which is best treated with multitarget drugs, such as atypical antipsychotics. Previously, using structure-based virtual screening, we found a virtual hit, D2AAK1, with nanomolar affinity for dopamine and serotonin receptors important in schizophrenia pharmacotherapy. As a part of an optimization campaign of D2AAK1, we obtained 17 derivatives that also display a multitarget profile. Selected compounds were tested against off-targets in schizophrenia, i. e., histamine H 1 receptor and muscarinic M 1 receptor, and these did not display considerable affinity for these receptors. The two most promising compounds were subjected to behavioral studies. These compounds decreased amphetamineinduced hyperactivity in mice which indicates their antipsychotic potential. The compounds did not interfere with the memory consolidation in mice, as determined in the passive avoidance test. The favorable pharmacological profile of these compounds was rationalized using molecular modeling.

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Comorbidity and Suicidality in Patients Diagnosed With Panic Disorder/Agoraphobia and Major Depression

Cited by 12 publications

References 31 publications

Assessment of Severity of Panic Disorder with co-morbid Depression and quality of life

Assessment of Severity of Panic Disorder with co-morbid Depression and quality of life

Kindling epileptogenesis and panic-like behavior: Their bidirectional connection and contribution to epilepsy-associated depression

Multitarget Derivatives of D2AAK1 as Potential Antipsychotics: The Effect of Substitution in the Indole Moiety

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