Comorbidity between depressive symptoms and substance use in-patients hospitalized for non-psychiatric diseases

Campuzano-Cortina, Carolina; Feijoó-Fonnegra, Luisa María; Manzur-Pineda, Karen; Palacio-Muñoz, María; Rendón-Fonnegra, Julián; Montoya, Laura; Berrouet, Marie Claire; Restrepo, Diana

doi:10.1016/j.rcpeng.2021.05.001

Cited by 4 publications

(7 citation statements)

References 36 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Although in our study women tended to have more DD than men (53.8% vs. 32.7%), differences were not significant, probably related to their low number. This is in contrast with other studies, where women with SUD presented more DD than men [ 28 , 29 ]. Depression was the most common DD in both genders, while panic and generalized anxiety were more frequent in women.…”

Section: Discussioncontrasting

confidence: 99%

See 1 more Smart Citation

Dual Disorders in the Consultation Liaison Addiction Service: Gender Perspective and Quality of Life

Ferrer-Farré

Dinamarca

Mestre-Pintó

et al. 2021

JCM

View full text Add to dashboard Cite

Dual disorders (DD) and gender differences comprise an area of considerable concern in patients with substance use disorder (SUD). This study aims to describe the presence of DD among patients with SUD admitted to a general hospital and attended by a consultation liaison addiction service (CLAS), in addition to assessing its association with addiction severity and quality of life from a gender perspective, between 1 January and 30 September 2020. The dual diagnosis screening interview (DDSI), the severity of dependence scale (SDS), and the WHO well-being index were used to evaluate the patients. In the overall sample, DD prevalence was 36.8%, (women: 53.8% vs. men: 32.7%, NS). In both genders the most prevalent DD was depression (33.8%, women: 46.2% vs. men: 30.9%, p = 0.296). Women presented more panic disorders (46.2% vs. 12.7%, p = 0.019) and generalized anxiety (38.5% vs. 10.9%, p = 0.049) than men. When DD was present, women had worse quality of life than men (21.7 vs. 50 points, p = 0.02). During lockdown period 77 patients were attended to and 13 had COVID-19 infection, with no differences in relation to sociodemographic and consumption history variables. The study confirms a high prevalence of DD among patients with SUD admitted to a general hospital for any pathology, and its being associated with worse quality of life, particularly in women.

show abstract

Section: Discussioncontrasting

confidence: 99%

“…This prevalence is described for the first time in a CLAS of a general hospital. Other studies had reported a depression incidence of 10–15% in general hospital inpatients [ 27 , 28 ], but not in SUD patients.…”

Section: Discussionmentioning

confidence: 97%

Dual Disorders in the Consultation Liaison Addiction Service: Gender Perspective and Quality of Life

Ferrer-Farré

Dinamarca

Mestre-Pintó

et al. 2021

JCM

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 99%

“…Various clinical studies carried out on cocaine-dependent women have shown a high prevalence and concurrence between depression and substance use (Campuzano-Cortina et al ., 2021). These studies indicated that 27.4% of women, between 30 and 47 years old, showed a significant association between cocaine abuse and severe symptoms of depression (Campuzano-Cortina et al ., 2021). They also found a high prevalence, between 15% and 50% of women, between substance use disorders and psychiatric comorbidities, such as depression, stress, and mood swings, among perimenopausal, menopausal, and postmenopausal women (Allen et al ., 2003; Milic et al ., 2018).…”

Section: Introductionmentioning

confidence: 99%

Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats

Barbosa-Méndez,

Salazar-Juárez

2023

Behavioural Pharmacology

View full text Add to dashboard Cite

Epidemiological studies have mentioned that cocaine use disorder (CUD) has increased in the last decade among women; these show endocrine and reproductive disorders and a high propensity to stress and depression disorders. Mirtazapine—a tetracyclic antidepressant—decreases cocaine-induced locomotor activity and locomotor sensitization in male rats. The objective of this study was to evaluate if estradiol alters the efficacy of mirtazapine to decrease cocaine-induced locomotor activity in sham and ovariectomized female rats. Three hundred and twenty adult female Wistar rats were assigned to three experimental protocols. For experiments, 1–3, female rats were daily dosed with 10 mg/kg of cocaine during the 10 days of induction and expression of locomotor sensitization. During drug withdrawal (30 days), cocaine was withdrawn and the groups received daily mirtazapine, estradiol, or saline. In addition, the females underwent sham or ovariectomy surgery. Tamoxifen was administered during the antagonism phase. After each administration, locomotor activity for each animal was recorded for 30 min in activity chambers. The dosage of mirtazapine reduces estradiol-induced enhancement in cocaine-dependent locomotor activity during the expression of locomotor sensitization in sham and ovariectomized female rats. As well as they showed that estradiol co-dosed with mirtazapine enhances the efficacy of mirtazapine to decrease cocaine-induced locomotor activity. Finally, tamoxifen enhanced the estradiol and mirtazapine-induced decrease in the cocaine motor effect in female rats. Mirtazapine may be considered an effective therapeutic option for the treatment of CUD in women, even in those who are on hormonal treatment or antidepressant therapy with estradiol.

show abstract

“…In Latin America, patients with chronic disease are more likely to suffer psychological distress than patients with acute disease. Chronic disease patients may be lonely and socially isolated [1], and have a higher incidence of substance use than general population [2]. When patients suffer from both physical ailments and mental health problems, they are more likely to have prolonged hospital stays [3].Researchers in Latin American have sought to identify associations and factors that predict the risk hospitalized patients will develop mental health problems.…”

mentioning

confidence: 99%

Why is Mental Health Care Necessary During Hospitalization?

Yánez

2022

Int J Public Health

View full text Add to dashboard Cite

The IJPH series "Young Researcher Editorial" is a training project of the Swiss School of Public Health.Seriously ill or injured patients may require hospitalization to restore their physical health, but admission to hospital may have reduce the psychological and emotional well-being of patients and threaten their social stability. To understand health consequences beyond physical well-being, we must better understand the effect of hospital stays on patient mental health. In Latin America, patients with chronic disease are more likely to suffer psychological distress than patients with acute disease. Chronic disease patients may be lonely and socially isolated [1], and have a higher incidence of substance use than general population [2]. When patients suffer from both physical ailments and mental health problems, they are more likely to have prolonged hospital stays [3].Researchers in Latin American have sought to identify associations and factors that predict the risk hospitalized patients will develop mental health problems. A study in Paraguay found that factors such as diagnosis, cause of hospitalization, prognosis and length of stay may predict the likelihood that patients will develop anxiety disorders and depression after prolonged hospitalization [4]. And a study at a Burn Unit in Baranquilla, Colombia found that a long hospital stay is associated with anxious-depressive states, lower patient's capacity for emotional expression and adaptation disorders [5]. Both of these studies suggest that patients would benefit from mental health care interventions while they are in hospital.Though non-pharmacological mental health care effectively reduces anxiety, distress, and pain, improves self-esteem and coping capacity, and increases the likelihood people will accept treatment, spend less time in the hospital, and even need less anesthesia and fewer analgesics [6], can Latin American health care systems provide it? Mental health disorders account for over a third of total disabilities in the Americas and current investment is too low to effectively reduce the public health burden of these diseases [7]. In Latin America, this has sometimes created large disparities in mental health care: those occupying the lowest socioeconomic strata have least access to care because patients must spend money out-of-pocket to use private services [8]. In these systems, mental health is not considered a human right that should be available to all, regardless of their socioeconomic status.Provision of mental health care is already limited in health care systems based on the traditional medical-biological model of care. A 2014 study in Ecuador found that only 1.46% of the total budget for public health was spent on mental health care, and more than half that funding went to psychiatric hospitals, stripping resources from the first and second levels of care [9]. The World Health Organization's Comprehensive Plan of Action makes clear that there is a severe shortage of specialized and general mental health professionals: almost half o...

show abstract

Comorbidity between depressive symptoms and substance use in-patients hospitalized for non-psychiatric diseases

Cited by 4 publications

References 36 publications

Dual Disorders in the Consultation Liaison Addiction Service: Gender Perspective and Quality of Life

Dual Disorders in the Consultation Liaison Addiction Service: Gender Perspective and Quality of Life

Estradiol enhances the mirtazapine effects on the expression of cocaine-induced locomotor sensitization in female rats

Why is Mental Health Care Necessary During Hospitalization?

Contact Info

Product

Resources

About