Comorbidity Genes of Alzheimer’s Disease and Type 2 Diabetes Associated with Memory and Cognitive Function

Abstract

Alzheimer’s disease (AD) and type 2 diabetes mellitus (T2DM) are comorbidities that result from the sharing of common genes. The molecular background of comorbidities can provide clues for the development of treatment and management strategies. Here, the common genes involved in the development of the two diseases and in memory and cognitive function are reviewed. Network clustering based on protein–protein interaction network identified tightly connected gene clusters that have an impact on memory and cognition among the comorbidity genes of AD and T2DM. Genes with functional implications were intensively reviewed and relevant evidence summarized. Gene information will be useful in the discovery of biomarkers and the identification of tentative therapeutic targets for AD and T2DM.

Exploring the Potential Role of Oligodendrocyte-Associated PIP4K2A in Alzheimer’s Disease Complicated with Type 2 Diabetes Mellitus via Multi-Omic Analysis

“…Furthermore, identifying comorbidity genes shared between AD and T2DM has provided valuable insights into the common molecular mechanisms contributing to the memory and cognitive impairments observed in both diseases. Network clustering based on protein–protein interaction networks has identified gene clusters with significant impacts on memory and cognition, offering potential biomarkers and therapeutic targets [ 18 ]. Nonetheless, the exact mechanisms underlying the link between AD and T2DM are still not fully understood and are a topic of ongoing research.…”