Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry

Sweeney, J; Patterson, Chris; Menzies‐Gow, Andrew; Niven, Rob; Mansur, Adel; Bucknall, Christine; Chaudhuri, Rekha; Price, David; Brightling, Christopher E.; Heaney, Liam G.

doi:10.1136/thoraxjnl-2015-207630

Cited by 292 publications

(257 citation statements)

References 26 publications

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“…Conversely, co-morbidities may be caused by severe asthma; steroid treatment is associated with an increased risk of iatrogenic co-morbidities including obesity, osteoporosis, diabetes, depression, and gastrointestinal reflux [1,60,61](Table 2). …”

Section: Systematic Assessment Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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Although a minority of asthma patients suffer from severe asthma, they represent a major clinical challenge in terms of poor symptom control despite high-dose treatment, risk of exacerbations, and side effects. Novel biological treatments may benefit patients with severe asthma, but are expensive, and are only effective in appropriately targeted patients. In some patients, symptoms are driven by other factors than asthma, and all patients with suspected severe asthma (‘difficult asthma’) should undergo systematic assessment, in order to differentiate between true severe asthma, and ‘difficult-to-treat’ patients, in whom poor control is related to factors such as poor adherence or co-morbidities. The Nordic Consensus Statement on severe asthma was developed by the Nordic Severe Asthma Network, consisting of members from Norway, Sweden, Finland, Denmark, Iceland and Estonia, including representatives from the respective national respiratory scientific societies with the aim to provide an overview and recommendations regarding the diagnosis, systematic assessment and management of severe asthma. Furthermore, the Consensus Statement proposes recommendations for the organization of severe asthma management in primary, secondary, and tertiary care.

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Section: Systematic Assessment Of Severe Asthmamentioning

confidence: 99%

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Porsbjerg

Ulrik

Skjold

et al. 2018

European Clinical Respiratory Journal

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“…In the European Unbiased Biomarkers for the Prediction of Respiratory Disease Outcomes (UBIOPRED) cohort of severe asthma, a high incidence of upper airway symptoms was observed, with the presence of NP in 25% of adult subjects [21]. The impact of upper airway comorbidities on asthma severity and control was also reported in the US Severe Asthma Research Program (SARP) study and in the UK Difficult Asthma National Registry [22]. Epidemiological examinations and evidence-based studies are often lacking in the pediatric population.…”

Section: Epidemiogical Evidencementioning

confidence: 89%

Rhinosinutis and Asthma in Children

et al. 2018

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Rhinosinusitis and asthma are two comorbid conditions that lead to pathological and clinical diseases affecting the respiratory tract. They are connected by significant anatomical, epidemiological, pathophysiological, and clinical evidence, and also share therapeutic principles. The aim of this review is to provide an updated overview of the existing link between rhinosinusitis and asthma focusing on the pediatric age.

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“…This is usually around 50% of those assessed (51% in the paper of VAN DER MEER et al [1]). As has recently been confirmed, these patient run considerable risk of morbidity from oral steroids, either as frequent short bursts or continuous treatment [9]. Current data suggests that not all asthma is the same and characterising the subtype of asthma may be helpful [10].…”

mentioning

confidence: 85%

Assessing severe asthma

Robinson

2016

Eur Respir J

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Comorbidity in severe asthma requiring systemic corticosteroid therapy: cross-sectional data from the Optimum Patient Care Research Database and the British Thoracic Difficult Asthma Registry

Cited by 292 publications

References 26 publications

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Nordic consensus statement on the systematic assessment and management of possible severe asthma in adults

Rhinosinutis and Asthma in Children

Assessing severe asthma

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