Comorbidity modulates non invasive ventilation-induced changes in breath print of obstructive sleep apnea syndrome patients

Incalzi, Raffaele Antonelli; Pennazza, Giorgio; Scarlata, Simone; Santonico, Marco; Vernile, Chiara; Cortese, Livio; Frezzotti, Elena; Pedone, Claudio; D’Amico, A.

doi:10.1007/s11325-014-1065-y

Cited by 38 publications

(25 citation statements)

References 16 publications

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“…Interestingly, findings from Greulich et al . in 2013 suggested that e-nose might be used to screen subjects more likely to be diagnosed to have OSAS by PSG 22 ; however, the study compares OSAS patients with healthy subjects, whereas in real life the differential diagnosis could vary depending on the clinical context 20 . Dragonieri et al .…”

Section: Introductionmentioning

confidence: 99%

Screening of Obstructive Sleep Apnea Syndrome by Electronic-Nose Analysis of Volatile Organic Compounds

Scarlata

Pennazza

Santonico

et al. 2017

Sci Rep

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Obstructive Sleep Apnea Syndrome (OSAS) carries important social and economic implications. Once the suspicion of OSAS has arisen, Polysomnography (PSG) represents the diagnostic gold standard. However, about 45% of people who have undergone PSG are free from OSAS. Thus, efforts should be made to improve the selection of subjects. We verified whether the pattern of Volatile Organic Compounds (VOCs) helps to select patients amenable to PSG. We studied 136 subjects (20 obese non-OSAS, 20 hypoxic OSAS, 20 non-hypoxic OSAS, and 20 non-hypoxic Chronic Obstructive Pulmonary Disease (COPD) vs 56 healthy controls) without any criteria of exclusion for comorbidity to deal with a real-life population. VOCs patterns were analyzed using electronic-nose (e-nose) technology. A Discriminant Analysis (Partial Least Square-Discriminant Analysis) was performed to predict respiratory functions and PSG parameters. E-nose distinguished controls (100% correct classification) from others and identified 60% of hypoxic, and 35% of non-hypoxic OSAS patients. Similarly, it identified 60% of COPD patients. One-by-one group comparison yielded optimal discrimination of OSAS vs controls and of COPD vs controls (100% correct classification). In conclusion, e-nose technology applied to breath-analysis can discriminate non-respiratory from respiratory diseased populations in real-life multimorbid populations and exclude OSAS. If confirmed, this evidence may become pivotal for screening purposes.

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Section: Introductionmentioning

confidence: 99%

Screening of Obstructive Sleep Apnea Syndrome by Electronic-Nose Analysis of Volatile Organic Compounds

Scarlata

Pennazza

Santonico

et al. 2017

Sci Rep

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“…In this clinical trial, only the gas sensor array is employed. The transducers used for the gas sensor array are seven quartz crystals with a resonance frequency of 20 MHz in the thickness shear mode covered with a combination of anthocyanins extracted by three different plant tissues: red rose, red cabbage, and blue hortensia [ 14 ].…”

Section: Methodsmentioning

confidence: 99%

“…[ 15 , 16 ]. Each patient was asked to breathe for 3-min at tidal volume into a dedicated storage device for direct sampling of exhaled breath on an adsorbing cartridge [ 14 ]. The adsorbent cartridge used in this work was a Tenax GR by Supelco [ 17 ].…”

Section: Methodsmentioning

confidence: 99%

Multi-Sensor Approach for the Monitoring of Halitosis Treatment via Lactobacillus brevis (CD2)—Containing Lozenges—A Randomized, Double-Blind Placebo-Controlled Clinical Trial

Marchetti

Tecco

Santonico

et al. 2015

Sensors

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The aim of this randomized clinical trial was to evaluate whether a recently described multi-sensor approach called BIONOTE® is accurate enough to verify the efficacy of treatment of patients with halitosis. A treatment with Lactobacillus brevis (CD2)–containing lozenges, compared with placebo was tested. The BIONOTE® was compared with traditional techniques used to detect halitosis: OralChroma™ and two calibrated odor judges enrolled for the organoleptic assessments. Twenty patients (10 treated and 10 placebo), suffering from active phase halitosis were included in the study. Treatment consisted of Lactobacillus brevis (CD2)—containing lozenges or placebo, 4 tablets/day for 14 days. t0 was before the beginning of the study; t1 was day 7 and t2 was day 14. The effectiveness of treatment was assessed through: (1) Rosenberg score; (2) Winkel tongue coating index (WTCI) anterior and posterior; (2) OralChroma™; (3) the new developed multi-sensor approach, called BIONOTE® (test technique). Only the WTCI anterior revealed statistically significant changes between t0 and t2 data (p = 0.014) in the treated group. Except for the WTCI anterior, all diagnostic methods revealed the lack of effectiveness for halitosis of a 14-days treatment with Lactobacillus brevis (CD2)–containing lozenges. The BIONOTE® multisensor system seems accurate in addition to OralChroma™ to assess the initial condition of halitosis and its mitigation during treatment.

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“…The available evidence on the e-nose shows an optimal diagnostic capacity for lung neoplasms, even at their initial stages [47]. Furthermore, the e-nose can help in classifying patients with COPD and can detect changes in breath pattern after nocturnal ventilation in patients with Obstructive Sleep Apnea [48]. The breath pattern measures have good reproducibility in both healthy and COPD subjects [49].…”

Section: New Horizons: Analysis Of Exhaled Gases Post-processing Imamentioning

confidence: 99%

Aging Airways: between Normal and Disease. A Multidimensional Diagnostic Approach by Combining Clinical, Functional, and Imaging Data

Occhipinti¹,

Larici²,

Bonomo³

et al. 2017

Aging and disease

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The lack of data on lung function decline in the aging process as well as the lack of gold standards to define obstructive and restrictive respiratory disease in older people point out the need for a multidimensional assessment and interpretation of the aging airways. By integrating clinical data together with morphologic and morphometric findings clinicians can assess the airways with a more comprehensive perspective, helpful in the interpretation of the “grey zone” between normal aging and disease. This review focuses on the value of a multidimensional approach in the study of the aging airways, including clinical findings, respiratory function tests, and imaging as parts of a whole. Nowadays this multidimensional diagnostic approach can be used in daily clinical practice. In next future, it can be implemented by the analysis of exhaled gases, post-processing imaging techniques, and genetic analysis, that will hopefully reduce the gaps in knowledge of normal aging and airway disease in older people.

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Comorbidity modulates non invasive ventilation-induced changes in breath print of obstructive sleep apnea syndrome patients

Abstract: We found that BP change after a single night of CPAP largely depends upon comorbidity. Comorbidity likely contributes to phenotypic variability in OSAS population. BP might qualify as a surrogate index of the response to and, later, compliance with CPAP.

Cited by 38 publications

References 16 publications

Screening of Obstructive Sleep Apnea Syndrome by Electronic-Nose Analysis of Volatile Organic Compounds

Screening of Obstructive Sleep Apnea Syndrome by Electronic-Nose Analysis of Volatile Organic Compounds

Multi-Sensor Approach for the Monitoring of Halitosis Treatment via Lactobacillus brevis (CD2)—Containing Lozenges—A Randomized, Double-Blind Placebo-Controlled Clinical Trial

Aging Airways: between Normal and Disease. A Multidimensional Diagnostic Approach by Combining Clinical, Functional, and Imaging Data

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