Comorbidity of Asperger's syndrome and Bipolar disorder

Raja, Michele; Azzoni, Antonella

doi:10.1186/1745-0179-4-26

Cited by 20 publications

(17 citation statements)

References 37 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…These data are in accord to the literature [13][14][15][16] (prevalence of 2% -9%, usually in adolescence). Depression occurred in 5.2%, with onset in adulthood, compared with 0.9% evidenced by Simonoff [3].…”

Section: Discussionsupporting

confidence: 92%

Clinical and therapeutic implications of psychiatric comorbidity in high functioning autism/Asperger syndrome: An Italian study

Giovinazzo¹,

Marciano²,

Giana³

et al. 2013

OJPsych

View full text Add to dashboard Cite

The present study describes the occurrence of psychiatric comorbid disorders in a cohort of 86 high functioning autism (HFA)/Asperger syndrome (AS) patients, examined at Child Neurology and Psychiatry Unit of Tor Vergata University. 38 patients out of 86 (44.2%) presented one or more psychiatric comorbidities, such as mood disorders, Attention Deficit/Hyperactivity Disorder (ADHD), Tourette syndrome (TS), anxiety disorders, including obsessive-compulsive disorder (OCD), and psychotic symptoms. We compared our sample with the evidences from the scientific literature on psychiatric comorbidity in ASD patient, in particular in HFA/AS. In this paper we focus on the high frequency of comorbid psychiatric disorders in HFA/AS patients, such as mood disorders, Attention Deficit/Hyperactivity Disorder (ADHD), Tourette syndrome (TS), anxiety disorders, including obsessive-compulsive disorder (OCD), and psychosis, including schizophrenia. We analyzed rates of all psichiatric comorbidities diagnosed in a sample of HFA/AS subjects and we compared findings from our study with the evidences from the scientific literature on psychiatric comorbidity in ASD patients, in particular HFA/AS. We point out that comorbid psychiatric symptoms can be hardly diagnosed, because they could present atipically in ASDs then in general population. Furthermore, they could be masked by ASD core symptoms.

show abstract

Section: Discussionsupporting

confidence: 92%

Clinical and therapeutic implications of psychiatric comorbidity in high functioning autism/Asperger syndrome: An Italian study

Giovinazzo¹,

Marciano²,

Giana³

et al. 2013

OJPsych

View full text Add to dashboard Cite

show abstract

“…The studies conducted in this field are different from a methodological point of view and do not permit an appropriate comparison of the available data. In ASD samples, BD is often underestimated, 49 especially because of the communication difficulties and low IQ that may complicate the correct identification of the clinical picture. Most studies on BD comorbidity have been conducted in children and adolescents, where BD is often characterized by atypical characteristics, such as irritability, mood lability, behavioral disturbances, and psychotic features, which are frequently associated with attention deficit hyperactivity disorder (ADHD), conduct, and multiple anxiety disorders.…”

Section: Psychiatric Comorbiditymentioning

confidence: 99%

Clinical features, developmental course, and psychiatric comorbidity of adult autism spectrum disorders

Vannucchi

Masi

Toni³

et al. 2013

CNS Spectr.

View full text Add to dashboard Cite

Autism spectrum disorders (ASDs) include a heterogeneous group of neurodevelopmental disorders with early onset in childhood. ASDs should be considered lifelong clinical entities, although there is a certain variability in developmental trajectories, and therefore should be considered of great interest also for adulthood psychiatrists. A few studies have been carried out to explore the clinical picture and course development of these disorders during adulthood, or their relationship with other mental disorders. Indeed, ASDs often share overlapping features with other disorders, such as schizophrenia and obsessive-compulsive, mood, and personality disorders, and as a result misdiagnoses often occur. The aim of this review is to summarize the available literature on ASDs in adulthood with a specific focus on the clinical picture, course, and psychiatric comorbidity. It is proposed that a careful diagnostic screening for ASDs in adults would contribute to clarifying the relationship with comorbid psychiatric disorders, while improving the possibility of treatment and outcome of such conditions.

show abstract

“…The chances of comorbidity of the disorders are also considerably strong with validated literature support [9, 10, 20]. ASDs and BP have also been shown to implicate a few common symptoms viz., sleep deprivation, depression, anxiety and social-behavioral problems.…”

Section: Discussionmentioning

confidence: 99%

A systems biological study on the comorbidity of autism spectrum disorders and bipolar disorder

Ragunath¹,

Chitra²,

Mohammad³

et al. 2011

Bioinformation

View full text Add to dashboard Cite

Autism Spectrum Disorder (ASD) is a “spectrum” of disorders, characterized by varying degrees of symptoms ranging from mild to severe. Among Psychiatric disorders, Autism Spectrum Disorders have the strongest evidence for a genetic basis, yet the search for specific genes contributing to these often devastating developmental syndromes has proven extraordinarily difficult. Bipolar Disorder (BP) is a manic-depressive disorder whose symptoms are characterized by extremities in moods. It is also called as the “Mood disorder”. BP, like, ASD also has a strong genetic basis and identification of the candidate genes still remains an ongoing effort. Literature studies point to the hypothesis that ASD and BP have good chances of comorbidity and that they may share common pathways for their manifestation. But this hypothesis has not been worked on in depth. Thus, the study focuses on identifying the chances of their comorbidity by identifying their common pathways and the genes involved in the pathways and also discuss the degree of chances of their comorbidity based on the genes involved in the common pathways. Networks for the genes are also constructed to represent their commonness or uniqueness for the disorders.

show abstract

Comorbidity of Asperger's syndrome and Bipolar disorder

Cited by 20 publications

References 37 publications

Clinical and therapeutic implications of psychiatric comorbidity in high functioning autism/Asperger syndrome: An Italian study

Clinical and therapeutic implications of psychiatric comorbidity in high functioning autism/Asperger syndrome: An Italian study

Clinical features, developmental course, and psychiatric comorbidity of adult autism spectrum disorders

A systems biological study on the comorbidity of autism spectrum disorders and bipolar disorder

Contact Info

Product

Resources

About