Comorbidity of bipolar I disorder and conduct disorder: a familial risk analysis

Wozniak, Janet; Wilens, Timothy E.; DiSalvo, Maura; Farrell, Abigail; Wolenski, Rebecca; Faraone, Stephen V.; Biederman, Joseph

doi:10.1111/acps.13013

Cited by 10 publications

(5 citation statements)

References 32 publications

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“…In a series of manuscripts, we systematically explored all the comorbidities present in youth diagnosed with bipolar disorder (Wilens, Biederman, Forkner, et al, 2003): conduct disorder (Biederman, Mick, Prince, et al, 1999;Biederman, Faraone, Wozniak, & Monuteaux, 2000;Biederman, Fitzgerald et al, 2018;; T. J. Wozniak et al, 2001Wozniak et al, , 2019, substance use disorders (T. Spencer et al, 1999;Wilens et al, 2004Wilens et al, , 2016, anxiety disorders Harpold et al, 2005;Joshi, Mick, Wozniak, Geller, et al, 2010;Joshi, Wozniak, Petty, Vivas, et al, 2010;Wozniak et al, 2002), and autism spectrum disorder (Joshi, Biederman, Petty, Goldin, et al, 2013;Joshi et al, 2018;. We explored the differences between unipolar and bipolar depression (Biederman et al, 2014;Wozniak et al, 2004).…”

Section: Pediatric Bipolar Disorder (By Janet Wozniak Md)mentioning

confidence: 99%

“…Biederman, Mick, Wozniak et al, 2003; Biederman, Mick, Faraone, et al, 2006; T. J. Spencer et al, 2001; Wozniak et al, 2001, 2019), substance use disorders (T. Spencer et al, 1999; Wilens et al, 2004, 2016), anxiety disorders (Biederman, Wozniak, Martelon, et al, 2013; Harpold et al, 2005; Joshi, Mick, Wozniak, Geller, et al, 2010; Joshi, Wozniak, Petty, Vivas, et al, 2010; Wozniak et al, 2002), and autism spectrum disorder (Joshi, Biederman, Petty, Goldin, et al, 2013; Joshi et al, 2018; Joshi, Biederman et al, 2012; Wozniak et al, 1997).…”

Section: Pediatric Bipolar Disorder (By Janet Wozniak Md)mentioning

confidence: 99%

See 1 more Smart Citation

In Memoriam: Professor Joseph Biederman’s Contributions to Child and Adolescent Psychiatry

Faraone,

Newcorn,

Wozniak

et al. 2024

J Atten Disord

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Objective: To provide an overview of Joe Biederman’s contributions to child and adolescent psychiatry. Method: Nine colleagues described his contributions to: psychopharmacology, comorbidity and genetics, pediatric bipolar disorder, autism spectrum disorders, Tourette’s and tic disorders, clinical and neuro biomarkers for pediatric mood disorders, executive functioning, and adult ADHD. Results: Joe Biederman left us with many concrete indicators of his contributions to child and adolescent psychiatry. He set up the world’s first pediatric psychopharmacology clinic and clinical research program in child adolescent psychiatry. As a young faculty member he began a research program that led to many awards and eventual promotion to full professor at Harvard Medical School. He was for many years the most highly cited researcher in ADHD. He achieved this while maintaining a full clinical load and was widely respected for his clinical acumen. Conclusion: The world is a better place because Joe Biederman was here.

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Section: Pediatric Bipolar Disorder (By Janet Wozniak Md)mentioning

confidence: 99%

Section: Pediatric Bipolar Disorder (By Janet Wozniak Md)mentioning

confidence: 99%

In Memoriam: Professor Joseph Biederman’s Contributions to Child and Adolescent Psychiatry

Faraone,

Newcorn,

Wozniak

et al. 2024

J Atten Disord

View full text Add to dashboard Cite

show abstract

“…Regarding comorbidity, two broad patterns have been described, the first with ADHD and disruptive behavior disorders, such as ODD and Conduct Disorder (CD), and the second with anxiety disorders, which may define specific subtypes and developmental pathways of BD [ 11 ]. The first pattern includes preexisting ADHD [ 12 , 13 , 14 ], with rates ranging from 30% to 90%, often associated with ODD and/or conduct disorder (CD) [ 15 , 16 ]. The second pattern of comorbidity includes anxiety disorders, often multiple [ 17 , 18 ], and obsessive compulsive disorder (OCD) [ 19 ].…”

Section: Introductionmentioning

confidence: 99%

“…The second pattern of comorbidity includes anxiety disorders, often multiple [ 17 , 18 ], and obsessive compulsive disorder (OCD) [ 19 ]. Multiple anxiety disorders (MAD) have been more closely related to bipolarity [ 16 , 17 , 20 , 21 ]. The rates of ADHD comorbidity are particularly high in prepubertal children [ 12 , 22 ], and are confirmed when children are assessed after removing overlapping symptoms [ 23 ].…”

Section: Introductionmentioning

confidence: 99%

A Naturalistic Study of Youth Referred to a Tertiary Care Facility for Acute Hypomanic or Manic Episode

et al. 2020

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Background: Bipolar Disorders (BD) in youth are a heterogeneous condition with different phenomenology, patterns of comorbidity and outcomes. Our aim was to explore the effects of gender; age at onset (prepubertal- vs. adolescent-onset) of BD; and elements associated with attention deficit hyperactivity disorder (ADHD) and Substance Use Disorder (SUD) comorbidities, severe suicidal ideation or attempts, and poorer response to pharmacological treatments. Method: 117 youth (69 males and 57 females, age range 7 to 18 years, mean age 14.5 ± 2.6 years) consecutively referred for (hypo)manic episodes according to the Diagnostic and Statistical Manual of Mental Disorders, 54th ed (DSM 5) were included. Results: Gender differences were not evident for any of the selected features. Prepubertal-onset BD was associated with higher rates of ADHD and externalizing disorders. SUD was higher in adolescent-onset BD and was associated with externalizing comorbidities and lower response to treatments. None of the selected measures differentiated patients with or without suicidality. At a 6-month follow up, 51.3% of the patients were responders to treatments, without difference between those receiving and not receiving a psychotherapy. Clinical severity at baseline and comorbidity with Conduct Disorder (CD) and SUD were associated with poorer response. Logistic regression indicated that baseline severity and number of externalizing disorders were associated with a poorer outcome. Conclusions: Disentangling broader clinical conditions in more specific phenotypes can help timely and focused preventative and therapeutic interventions.

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“…In a USA based study on 26 bipolar youths aged 8-13, it was concluded that CD may co-exist with bipolar disorder (BD) at 69% lifetime comorbidity and 54% for episode comorbidity 2 . Bipolar 1 disorder and CD co-existence may represent a distinct subtype of either disorder in terms of presentation, course and treatments 3,4 . The combination of CD and BD in youth predicts high risks of substance use disorders in relatives suggesting a genetic predisposition 5 .…”

mentioning

confidence: 99%

DSM-5 conduct disorder and symptoms in youths at high risk of psychosis in Kenya with DSM-5 mental disorders and substance use: towards integrated management

Ndetei,

Mutiso,

Musyimi

et al. 2023

Sci Rep

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Little is known about the prevalence of Conduct Disorder (CD) and symptoms of CD in high risk psychosis persons at both clinical and community populations in LMICs and in particular Kenya. This study aimed to document (1) the prevalence of CD diagnosis and symptoms in youth who screened positive for psychosis and (2) the associated mental disorders and substance use in the same cohort in LMIC. The sample size was 536 students who had screened positive on the Washington Early Recognition Center Affectivity and Psychosis (WERCAP) from a population of 9,742 high school, college and university students, but had not converted to a psychotic disorder. We collected data on socio-demographic characteristics and used the following tools: Economic indicators tool; the Diagnostic Interview Schedule (DIS) tool for DSM-5 diagnosis; World Health Organization (WHO) Alcohol, Smoking, and Substance Involvement Screening Test (ASSIST). Basic descriptive statistics, chi-square test, Fisher's exact test, Pearson correlation and Poisson regression were conducted. Five percent (5%) of the respondents met the criteria for DSM-5 CD. Indeterminate CD comprised 10.1%. Male gender, all substances except hallucinogens lifetime, obsessive compulsive disorder, psychosis, agoraphobia, social phobia, drug abuse/dependence, antisocial personality disorder, oppositional defiant disorder, suicidality, WERCAP screen for bipolar disorder and WERCAP screen for schizophrenia were significantly (p < 0.05) associated with CD. Deceitfulness or theft criteria symptoms showed that CD had no significant gender difference. Criteria symptoms in aggression to people and animals, destruction of property and serious violations of rules were more common among males. Our findings suggest the need to screen for and diagnose CD, mental disorders and substance use in high risk psychosis youths in Kenya. This will inform integrated management.

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Comorbidity of bipolar I disorder and conduct disorder: a familial risk analysis

Cited by 10 publications

References 32 publications

In Memoriam: Professor Joseph Biederman’s Contributions to Child and Adolescent Psychiatry

In Memoriam: Professor Joseph Biederman’s Contributions to Child and Adolescent Psychiatry

A Naturalistic Study of Youth Referred to a Tertiary Care Facility for Acute Hypomanic or Manic Episode

DSM-5 conduct disorder and symptoms in youths at high risk of psychosis in Kenya with DSM-5 mental disorders and substance use: towards integrated management

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