2022
DOI: 10.7759/cureus.21527
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Comorbidity of Epilepsy and Depression: Associated Pathophysiology and Management

Abstract: Epilepsy is a neurological disorder characterized by recurrent unprovoked seizures. Depression may arise as a result of other mental or physical problems or as a side effect of the drugs used to treat such illnesses, or it could be caused by epilepsy-related structural abnormalities. However, physicians are hesitant to prescribe antidepressants to patients with epilepsy due to concerns about decreasing seizure thresholds and the harmful drug interactions between antidepressants and antiepileptic medicines. As … Show more

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Cited by 7 publications
(10 citation statements)
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“…These data are in line with published series on the prevalence of depression in patients with epilepsy. [9][10][11] Remarkably, only 43.7% of patients with NDDI-E score > 13 were on antidepressant medication or psychological treatment. This result suggests that more than half of the patients with a positive screening for major depressive disorder were untreated, similar to data published in other series of patients with a diagnosis of depression.…”
Section: Discussionmentioning
confidence: 99%
See 3 more Smart Citations
“…These data are in line with published series on the prevalence of depression in patients with epilepsy. [9][10][11] Remarkably, only 43.7% of patients with NDDI-E score > 13 were on antidepressant medication or psychological treatment. This result suggests that more than half of the patients with a positive screening for major depressive disorder were untreated, similar to data published in other series of patients with a diagnosis of depression.…”
Section: Discussionmentioning
confidence: 99%
“…5 Psychiatric comorbidities are frequent in patients with epilepsy, with a higher prevalence than in the general population, 6 being determined in up to 30%-50% of patients. [7][8][9][10][11][12] Mood disorders, including major depressive disorder, are particularly prevalent. 9 It is now recognized that the relationship between epilepsy and psychiatric comorbidities is bidirectional and complex.…”
Section: Introductionmentioning
confidence: 99%
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“…Possibly, better results may be achieved when a patient is prescribed carbamazepine, gabapentin, lamotrigine, topiramate or valproate. These antiepileptics have been documented to improve mood (Alhashimi et al, 2022;Shamabadi, 2022).…”
Section: Discussionmentioning
confidence: 99%