Comorbidity of migraine and epilepsy in childhood

Nesterovsky, Yu E; Zavadenko, N. N.

doi:10.17116/jnevro201811841100-106

Cited by 3 publications

(2 citation statements)

References 35 publications

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“…Further, studies also suggested that there are genetic relationships [19] as well as common underlying pathophysiological mechanisms including the imbalance between excitatory and inhibitory neurotransmitters in epilepsy and headache, especially for migraine [18,21]. Proposed theories for shared etiologies include ion channel dysfunction, glutamatergic mechanisms, and mitochondrial dysfunction [22,23]. These suggest that the cause of headache and epilepsy are multifactorial and hence need different diagnostic and interventional approaches [24].…”

Section: Introductionmentioning

confidence: 99%

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

2020

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Background: Headache is the symptom of pain in the face, head or neck that causes disability in most people with medical and neurological disorders. It frequently co-occurs with most chronic diseases such as epilepsy and significantly impacts the quality of life. However, epidemiologic data from different studies showed different rates of prevalence. Therefore, we conducted this review to summarize the available epidemiologic evidence on the topic and formulate recommendations for future research and clinical practice. Methods: We followed the preferred reporting items for systematic review and meta-analysis (PRISMA) guidelines. We systematically searched the literature using popular databases such as PubMed, EMBASE, Psych-INFO, and SCOPUS. We further scanned the reference lists of the eligible studies to supplement our electronic search. The Comprehensive Meta-Analysis software version 3.0 (CMA 3.0) was used to conduct a meta-analysis. Subgroup and sensitivity analysis were performed and Cochran's Q-and the I 2-test were used to assess the source of heterogeneity. The funnel plot and Egger's regression tests were used to assess potential publication bias. Results: A total of 17 studies conducted both in developed and developing countries including 5564 study participants were combined in this meta-analysis. The pooled estimated prevalence of headache among patients with epilepsy was 48.4%. The pooled estimated prevalence of Inter-Ictal headache (IIH) (42.2%) and Postictal headache (PIH) (43.1%) were higher when compared to tension-type headache (TTH) (26.2%), migraine with aura (26.0%) and migraine without aura (10.4%). The pooled prevalence of headache was 50.6% and 49.5% for developed and developing countries respectively. The pooled prevalence of headache among patients with epilepsy was considerably higher among females (63.0%) when compared to males (33.3%). Moreover, the pooled estimated prevalence of headache among patients with epilepsy was ranging from 46.0% to 52.2% in a leave-one-out sensitivity analysis. Conclusion: The pooled estimated prevalence of headache among patients with epilepsy was considerably high (48.4%). Screening and appropriate management of headaches among patients with epilepsy are warranted.

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Section: Introductionmentioning

confidence: 99%

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

2020

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“…7 Research on genetic and clinical features common to the etiopathogenesis of epilepsy and headaches has emphasised the imbalance of inhibitory and excitatory neurotransmitters. [8][9][10][11][12] The migraine comorbidity in epilepsy has been extensively examined. 13,14 The prevalence of migraine-like headaches in patients with seizure-related headaches varies among studies.…”

Section: Discussionmentioning

confidence: 99%

Characteristics and effects of headaches on quality of life in individuals with epilepsy in Çorum province of Turkey

ELİAÇIK,

AYKAÇ

2023

J Health Sci Med /JHSM /jhsm

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Aims: Varying headache prevalence rates have been reported in individuals with epilepsy in the literature. This study was investigate the frequency and types of headaches in individuals with epilepsy, and the impact of headaches on the clinical features and quality of life in this patient group. Methods: 150 individuals with epilepsy, 83 female and 67 male, were included in the study sample by random sampling method. Headaches were primarily defined as pre-ictal, ictal, and post-ictal headaches according to the temporal relationship with seizures. Headaches that were not temporally related to seizures were defined as inter-ictal headaches. Types and features of participants’ headaches were evaluated using the headache questionnaire consisting of 35 questions. Individuals’ quality of life was evaluated using the Quality of Life in Epilepsy Inventory (QOLIE-10). Results: Of the 150 participants included in the study, 73.33% had generalized, 20% focal, and 6.66% combined generalized focal epilepsy, and 41.33% had accompanying headache complaints. Of the participants with headaches, 35.48% were male and 64.51% were female. Inter-ictal headache, which was detected in 72.58% participants, was the most common type of headache. Tension and migrainous type headaches were more common among participants with inter-ictal headache, whereas migrainous type headaches were more common among participants with pre- and post-ictal headaches. There were statistically significant differences in the scores obtained from all three subscales of QOLIE-10 inventory between the participants with and without headache. Accordingly, quality of life was worse in the headache group than in the headache-free group (p

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Sporadic hemiplegic migraine (rare case in clinical practice)

Levitina

Rakhmanina

Lebedev

2022

Medicinskij alfavit

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The article describes the peculiarities of a rare disease – hemiplegic migraine in three patients (two boys aged 7 and 15 and a girl of 12 years old). The family history of migraine was not burdened. Attack symptoms were almost identical: hemiparesis, dysphasia, and headache. The electroencephalograms, magnetic resonance imaging in all patients not presented signs brain dysfunction. Analysis of the literature data has been carried out. Thediagnostic criteria for hemiplegic migraine, its differential diagnosis is described. The considered description increases the awareness of doctors on the issue, which is very rare in the practice of pediatrician and neurologist.

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Comorbidity of migraine and epilepsy in childhood

Cited by 3 publications

References 35 publications

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

The epidemiology of headaches among patients with epilepsy: a systematic review and meta-analysis

Characteristics and effects of headaches on quality of life in individuals with epilepsy in Çorum province of Turkey

Sporadic hemiplegic migraine (rare case in clinical practice)

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