Comorbidity of Panic Disorder and Major Depression: Results from a Family Study

Maier, W.; Buller, R.; Hallmayer, Joachim

doi:10.1007/978-3-642-73543-1_17

Cited by 5 publications

(4 citation statements)

References 12 publications

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“…Samples of patients with alcoholism only and patients with anxiety disorders are necessary to examine whether the associations described above extend to probands with no lifetime history of major depression. Previous family studies suggest that there may be forms of anxiety disorders that do not share aetiological factors with major depression (Cloninger et al 1981;Maier et al 1988). We are currently completing a family study of probands with pure alcoholism and pure anxiety to examine whether these findings extend to these groups as well.…”

Section: Discussionmentioning

confidence: 90%

“…Data on comorbidity of anxiety and affective disorders from family and twin studies were reviewed by Merikangas (1990). The results of numerous studies were inconsistent with respect to the familial overlap between anxiety and depression: there was evidence for pure forms of both major depression and anxiety disorders, with the 'pure' forms of anxiety breeding true within families (Cloninger et al 1981;Van Valkenburg et al 1984;Coryell et al 1988) and also for a 'mixed' form of anxiety and depression, in which anxiety and depression in families appear to have shared underlying aetiological factors (Leckman et al 1983;Kendler et al 1986;Maier et al 1988).…”

Section: Relationship Between the Anxiety Disorders And Depression: Pmentioning

confidence: 99%

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Comorbidity and co-transmission of alcoholism, anxiety and depression

1994

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SynopsisThis paper applies data from a family study of depression to assess patterns of comorbidity and co-transmission of alcoholism, anxiety disorders, and major depression. We found that all three disorders were strongly transmissible; however, alcoholism demonstrated the greatest degree of familial aggregation. The pairwise associations among depression, anxiety and alcoholism indicated that the traits are co-transmitted in families, especially depression and anxiety. Individual associations between traits (or comorbidity) were entirely explained by transmitted (perhaps genetic) agents, because the correlations between traits due to random environment were not significant. These findings have important implications for treatment, psychiatric nosology, and aetiological investigations of these conditions.

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Section: Discussionmentioning

confidence: 90%

Section: Relationship Between the Anxiety Disorders And Depression: Pmentioning

confidence: 99%

Comorbidity and co-transmission of alcoholism, anxiety and depression

1994

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“…The introduction of operational definitions of specific subtypes of anxiety states in DSM-III (American Psychiatric Association, 1980) has spurred numerous investigations of patterns of comorbidity between each of the major subtypes of anxiety and depression (e.g. panic and major depression, Maier et al, 1988; social phobia and depression, Schapira & Roth, 1970;Van Ameringen et al, 1991;Schneier & Hornig, 1992;Kendler & Kessler, 1993). However, the number of subjects used to examine these associations, after adjustment for relevant confounding factors, has often been too small for meaningful analysis.…”

mentioning

confidence: 99%

Comorbidity and Boundaries of Affective Disorders with Anxiety Disorders and Substance Misuse: Results of an International Task Force

et al. 1996

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Associations between affective disorders, anxiety disorders, and substance use disorders were examined in epidemiological studies conducted in Germany, Switzerland, Puerto Rico, and the mainland US. There was a remarkable degree of similarity across studies in the magnitude and type of specific disorders associated with the affective disorders. Comorbidity with affective disorders was greater for the anxiety disorders than for substance misuse. Panic disorder was the subtype of anxiety that was most highly comorbid with depression. Social phobia was the specific phobic type with the strongest association with the affective disorders. The magnitude of associations between substance misuse and affective disorders generally was quite low and less consistent across sites. No major differences were found in the patterns of comorbidity by gender or age group, affective subtype or prevalence period. The onset of anxiety disorders generally preceded that of depression, whereas alcohol misuse was equally likely to pre- or post-date the onset of affective disorders. Finally, comorbidity was associated with an elevation in treatment ratesacross all sites, confirming Berkson's paradox on an international level.

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“…Indeed, influential psychological models of anxiety disorders have postulated risk for developing panic disorder. Especially, because several family studies have established that panic disorder runs in families [10][11][12] , Biederman et al [12] concluded that parental panic disorder, regardless of comorbidity with major depression, was associated with an increased risk for panic disorder and agoraphobia in the offspring. Furthermore, findings from behavioral genetic studies point to the genetic influence on anxiety in childhood, which accounts for around one third of the variance in most cases [13] .…”

Section: Introductionmentioning

confidence: 99%

Attention Bias in Children of Patients with Panic Disorder

Schneider

Unnewehr²,

In‐Albon

et al. 2008

Psychopathology

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Cognitive models of panic disorder have emphasized the role of cognitive distortions in the maintenance of this disorder. Several studies have produced results consistent with this hypothesis, but it is still unclear whether cognitive biases precede anxiety disorders or whether they are a consequence of the disorder. In the present study, we compared children of individuals with panic disorder, children of individuals with animal phobia, and children of normal controls with respect to attentional bias with an emotional Stroop task, which included three types of words: panic-relevant, animal phobia-relevant, and neutral words. Our results revealed that children of panic patients did not show an attentional bias for panic-relevant stimuli. Results will be discussed in the context of theoretical models explaining the etiological factor of cognitive biases for the development of anxiety disorders.

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Comorbidity of Panic Disorder and Major Depression: Results from a Family Study

Cited by 5 publications

References 12 publications

Comorbidity and co-transmission of alcoholism, anxiety and depression

Comorbidity and co-transmission of alcoholism, anxiety and depression

Comorbidity and Boundaries of Affective Disorders with Anxiety Disorders and Substance Misuse: Results of an International Task Force

Attention Bias in Children of Patients with Panic Disorder

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