Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

Holmstrup, Palle; Damgaard, Christian; Olsen, Ingar; Klinge, Björn; Flyvbjerg, Allan; Nielsen, Claus Henrik; Hansen, Peter Riis

doi:10.1080/20002297.2017.1332710

Cited by 163 publications

(164 citation statements)

References 127 publications

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“…; Holmstrup et al . ; Khader, Dauod, El‐Qaderi, Alkafajei, & Batayha ; Kudiyirickal & Pappachan ; Meurman, Sanz, & Janket ; Montebugnoli et al . ; Nibali et al ; Spahr et al .…”

Section: Discussionunclassified

Oral health of adults with intellectual disabilities: a systematic review

Ward

Cooper

Hughes-McCormack

et al. 2019

J intellect Disabil Res

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Background There have been several past reports that adults with intellectual disabilities experience poor oral health (tooth loss, periodontal health and untreated dental caries). Loss of a functional dentition has serious consequences, including problems with chewing, swallowing, nutrition, speech, temporomandibular joint osteoarthritis and pain and systemic health conditions. Poor oral health is largely preventable through proactive oral care support. In recent years, social care provision for adults has changed, with deinstitutionalisation and home‐based personalised care now being the typical provision in high income countries. Hence, oral health inequalities might be reducing. However, there is limited recent evidence‐synthesis on the topic. We aimed to address this. Method PROSPERO registration number: CRD42018089880. We conducted a preferred reporting items for systematic reviews and meta‐analyses systematic review of publications since 2008. Four databases were searched with a clear search strategy, strict inclusion criteria for selection of papers, double scoring (two raters), systematic data extraction and quality appraisal of included papers. Results A total of 33/3958 retrieved articles were included, of which 14 were drawn from dental service users and 10 from Special Olympic athletes, therefore not necessarily being representative of the wider population with intellectual disabilities. Despite this limitation, adults with intellectual disabilities were still shown to experience poor oral health. High levels of poor oral hygiene and gingivitis were found, with many also affected by periodontitis and untreated dental decay. There is clear unmet need relating to both periodontal (gum) and tooth health, leading to tooth loss. Conclusions Despite reports in the past of poor oral health amongst adults with intellectual disabilities, and despite it being preventable, there remains a high burden of poor oral health. This highlights the need to raise awareness, and for polices on effective daily oral care, and appropriate service provision. The importance of oral health and its possible negative sequelae needs to be elevated amongst carers and professionals.

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“…; Holmstrup et al . ; Khader, Dauod, El‐Qaderi, Alkafajei, & Batayha ; Kudiyirickal & Pappachan ; Meurman, Sanz, & Janket ; Montebugnoli et al . ; Nibali et al ; Spahr et al .…”

Section: Discussionunclassified

Oral health of adults with intellectual disabilities: a systematic review

Ward

Cooper

Hughes-McCormack

et al. 2019

J intellect Disabil Res

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“…It has been proposed that periodontal disease, as a chronic infectious inflammatory disease, may be a risk factor for various systemic diseases, including dementia, although the scientific evidence is not conclusive. Dementia is considered a severe public health problem, with an estimated prevalence of more than 37 million cases worldwide that is expected to increase .…”

Section: Introductionmentioning

confidence: 99%

Systemic inflammatory impact of periodontitis on cognitive impairment

et al. 2019

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Objectives The role in dementia of systemic inflammation derived from periodontal disease is not fully elucidated. The objective of our study was to examine the impact of inflammation on the relationship between periodontitis and cognitive impairment. Methods We have designed a case (n = 171) and control (n = 131) study to determine the periodontal health status, grade of cognitive impairment/dementia and systemic inflammation level, the last being measured by analysis of 29 inflammatory biomarkers using multiplex techniques. Results At the time of sampling, 11 of the 29 inflammatory biomarkers were associated with cognitive impairment in patients with more severe periodontitis. However, the inflammatory response to severe periodontitis was more reduced (lower biomarker concentrations) in cases (with cognitive impairment or dementia) than in (cognitively healthy) controls, an unexpected finding. Conclusions Based on these results, we cannot confirm that systemic inflammation derived from periodontal disease plays a relevant role in the aetiology of cognitive impairment.

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“…Weitere Assoziationen von Parodontitis wurden berichtet [8]. Es bestehen Hinweise aus einer Untersuchung aus Taiwan, dass nach chirurgischer Parodontitisbehandlung das Erkrankungsrisiko für Psoriasis fast vollständig auf das der Normalbevölkerung zurückkehrt [9].…”

Section: Transfer In Die Praxis Von Prof Dr Vera Mahler (Langen)unclassified

Assoziation zwischen Psoriasis und Parodontitis bei der dermatologischen Untersuchung nicht vergessen

Mahler¹

2018

Kompass Dermatol

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Periodontitis and psoriasis are suggested to be co-occurring, chronic inflammatory conditions with overlapping characteristics. However, respective evidence is rare and data on risk factors of periodontitis in psoriasis patients are minimal. The aim of this study was to expand the evidence of psoriasis-associated periodontitis and establish a potential risk profile for periodontitis. In total, data from 209 exacerbated psoriasis patients were retrospectively analyzed on recordings of periodontitis and compared with those of 91 patients with chronic spontaneous urticaria (CSU). Analysis showed a significantly increased prevalence of periodontitis in psoriasis compared to CSU patients with an odds ratio of 3.76 (95% CI = 1.60-10.27, p = 0.001). Within the psoriatic subtypes, the presence of the inverse type (affecting intertriginous body areas) was strongly linked to periodontitis with an odds ratio of 5.11 (95% CI = 1.36-20.38, p = 0.006). These results are enlarging the evidence for psoriasis-associated periodontitis and identify a link between the inverse type of psoriasis and periodontitis.

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Comorbidity of periodontal disease: two sides of the same coin? An introduction for the clinician

Cited by 163 publications

References 127 publications

Oral health of adults with intellectual disabilities: a systematic review

Oral health of adults with intellectual disabilities: a systematic review

Systemic inflammatory impact of periodontitis on cognitive impairment

Assoziation zwischen Psoriasis und Parodontitis bei der dermatologischen Untersuchung nicht vergessen

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