COMP–Angiopoietin-1 Ameliorates Renal Fibrosis in a Unilateral Ureteral Obstruction Model

Angiopoietin-1 is essential in mouse vasculature during development and in response to injury

“…On the other hand, enhanced fibrosis is a major feature of wounds in Angpt1 del/^(E13.5) mice but was not reported in the COMP-Angpt1 study, suggesting at least one key difference between these wound closure phenotypes. Furthermore, the exaggerated fibrotic response in Angpt1 del/^(E13.5) mice is consistent with observations that COMP-Angpt1 attenuates renal fibrosis in a UUO model (34). Despite these differences, our studies suggest that inhibition of Angpt1 might be used to enhance wound closure, perhaps in different circumstances than COMP-Angpt1.…”

Roles of Angiopoietins in Kidney Development and Disease

“…60 Whereas angiopoietin expression has yet to be reported in these particular models, it has been studied in other kidney diseases that feature prominent tubulointerstitial lesions. Kim et al 61 performed unilateral ureteric obstruction in adult mice and noted that kidney Ang-1 levels fell. After a chimeric form of Ang-1, COMP-Ang-1, was transduced into the liver by an adenoviral vector, the result was increased kidney Tie-2 phosphorylation and preservation of peritubular capillaries in association with decreased macrophage numbers and decreased TGF-␤ expression.…”

Priming With Angiopoietin-1 Augments the Vasculogenic Potential of the Peripheral Blood Stem Cells Mobilized With Granulocyte Colony-Stimulating Factor Through a Novel Tie2/Ets-1 Pathway

“…16,17 The rationale for using COMP-Ang1 as a priming agent was our new finding that mob PBSCs express high levels of Tie2. We hypothesized that because of the high expression of the Tie2 receptor in mob PBSCs, these cells would be excellent candidates to embrace the various beneficial effects of COMP-Ang1.…”