In this paper, we present an efficient polymer two-mode (de)multiplexer with two cascaded horizontal waveguide asymmetric directional couplers (ADCs). Through extensive simulations, the optimized waveguide core dimensions were determined, and the distance L from the starting position of the first ADC to the cascaded position was 35300 µm. With the cascaded ADCs, the
E
21
x
mode of the wider waveguide was coupled into the
E
11
x
mode of the narrower waveguide with a coupling ratio of 96.73% at 1550 nm when the separation between the waveguide cores was 5 µm. The coupling ratio and extinction ratio of the fabricated (de)multiplexer reached a maximum of 96.12% and 14.21 dB at 1540 nm, respectively. The coupling ratios were greater than 90% in the wavelength range 1533–1565 nm with a minimum insertion loss of 9.75 dB. The influence of different cascaded positions on the mode coupling ratio, mainly caused by the large phase difference between the modes owing to the slowly varying envelope approximation, is analyzed theoretically and verified experimentally. The proposed cascaded two-mode (de)multiplexer can reduce the preparation process requirements and increase the channel capacity of optical communication systems.