Compact CdZnTe-based gamma camera for prostate cancer imaging

Cui, Yonggang; Lall, Terry; Tsui, B.M.W.; Yu, Jianzhong; Mahler, G.; Bolotnikov, A. E.; Vaska, P.; Geronimo, G. De; O’Connor, P.; Meinken, G.E.; Joyal, John L.; Barrett, John; Camarda, G.C.; Hossain, Anwar; Kim, Ki‐Hyun; Yang, Ge; Pomper, Marty G.; Cho, Steve; Weisman, Ken; Seo, Youngho; Babich, John W.; LaFrance, Norman; James, R. B.

doi:10.1117/12.901078

Cited by 3 publications

(1 citation statement)

References 3 publications

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“…Hybridyne Imaging Technologies [1] is introducing to the market (FDA approval was obtained in Spring of 2010) a prostate mini gamma probe ProxiScan ™ based on Cadmium Zinc Telluride (CZT) technology developed at Brookhaven National Laboratory [2]. However, the way the probe is implemented with the associated electronics, there is no room for the addition of an US sensor in the same package.…”

Section: Introductionmentioning

confidence: 99%

Development of a mini gamma camera for prostate imaging

Majewski

Proffitt²,

Stolin

2011

2011 IEEE Nuclear Science Symposium Conference Record

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We have tested a concept of a mini gamma camera based on monolithic arrays of MPPCs from Hamamatsu. CsI(TI), and Cs(Na) arrays and a thin scintillation GSO plate were tested with 122 keY gammas from "Co sources. The planned application requires placement of this mini-camera in an endorectal probe and thus needs to be very compact and possess high spatial resolution. The high sensitivity and high granularity collimator and gamma shield made out composite material (tungsten powder with epoxy) completes the detector package. We are developing the dual modality (hybrid) imaging prostate probe combining in one compact device a high resolution and high efficiency single gamma imager with an Ultrasound (US) sensor. The US component will typically provide not only the usual structural 3D information, as the standard TransRectal Ultrasound (TRUS) probe, but also the tissue differentiating information through proper US signal analysis, such as elastography. The mini gamma probe will provide the direct metabolic information related to the biological state of the prostate and specifically about the presence of any cancerous structures exhibiting increased metabolic activity, when used with the single gamma labeled dedicated imaging agents for prostate cancer. In addition to cancer diagnosis, the dual-modality Gamma/US prostate probe can be used in biopsy and in surgical guidance.

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Section: Introductionmentioning

confidence: 99%

Development of a mini gamma camera for prostate imaging

Majewski

Proffitt²,

Stolin

2011

2011 IEEE Nuclear Science Symposium Conference Record

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Application-specific nuclear medical in vivo imaging devices

Chaudhari¹,

Badawi²

2021

Phys. Med. Biol.

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Nuclear medical imaging devices, such as those enabling photon emission imaging (gamma camera, single photon emission computed tomography, or positron emission imaging), that are typically used in today’s clinics are optimized for assessing large portions of the human body, and are classified as whole-body imaging systems. These systems have known limitations for organ imaging, therefore application-specific devices have been designed, constructed and evaluated. These devices, given their compact nature and superior technical characteristics, such as their higher detection sensitivity and spatial resolution for organ imaging compared to whole-body imaging systems, have shown promise for niche applications. Several of these devices have further been integrated with complementary anatomical imaging devices. The objectives of this review article are to (1) provide an overview of such application-specific nuclear imaging devices that were developed over the past two decades (in the twenty-first century), with emphasis on brain, cardiac, breast, and prostate imaging; and (2) discuss the rationale, advantages and challenges associated with the translation of these devices for routine clinical imaging. Finally, a perspective on the future prospects for application-specific devices is provided, which is that sustained effort is required both to overcome design limitations which impact their utility (where these exist) and to collect the data required to define their clinical value.

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