Zanker plate is a widely used flow straightener to eliminate turbulence originating from pipe fittings in experimental fluid flow applications. In this paper, steady state, incompressible, swirling turbulent flow through Zanker plate has been studied. The solution and the analysis were carried out using finite volume CFD solver FLUENT 6.2. Five turbulence models were used in the numerical investigation and their results were compared with the pressure drop correlation of BS EN ISO 5167-2:2003. The turbulence models investigated here are the standard k-ε, realizable k-ε, the Reynolds Stress Model (RSM), the large Eddy Simulation (LES), and the Detached Eddy Simulation (DES). The results showed that the DES model gave the best agreement with the ISO pressure drop correlation, therefore, the model was used further to predict streamline patterns, vortex formations and separated flow regions. The effects of Zanker plate thickness and Reynolds number on the flow characteristics have been investigated as well.