The study of metamaterials has experienced rapid growth, particularly with the discovery of left-handed metamaterials. One promising technology for controlling electromagnetic waves in small structures is transmission-line metamaterial (TL-MTM), which can accurately determine various parameters, such as working frequency, bandwidth, and phase offsets. Antennas are essential components for receiving and transmitting signals in RF systems. Although the microstrip antenna is a popular choice due to its low cost and ease of manufacturing, it is limited in terms of size and frequency range. In this chapter, more than 100 papers are reviewed based on their methodology and performance to discuss various techniques for improving antenna performance, such as the use of artificial neural networks (ANN) and metamaterials. The insights presented in this chapter will aid in identifying, analyzing, and synthesizing the latest developments in the field of metamaterials.