Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression

Haruna, Fatima; Apeji, Yonni Eshovo; Oparaeche, Chinyere; Oyi, Avosuahi Rukayat; Gamlen, Michael

doi:10.1186/s43094-020-00055-9

Cited by 13 publications

(7 citation statements)

References 31 publications

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“…The results of this research were in line with the results of Haruna et al 5 , who co-processed MCC with crospovidone for direct compression to yield an excipient with a lower degree of plastic deformation. High values of Py represent brittle materials, while low values imply that the materials underwent plastic deformation readily 45 .…”

Section: Compaction and Compression Propertiessupporting

confidence: 91%

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Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves

et al. 2021

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Traditionally, the leafy part of Andrographis paniculata and Moringa oleifera have been widely reported to manage hypertension. Investigation of its pharmacological actions justifies its use. As part of formulation studies to standardize them, this study focused on their compaction and compression properties. Compacts equivalent to 250 mg of A. paniculata and M. oleifera were produced by compressing powders and granules at various compression pressure. Results show that M. oleifera met the WHO limit for ash values. Relative density values for granulated batches were higher, while their moisture content values were lower when compared to those of direct compression. The result from Heckel plots shows that batches deform mainly by plastic flow. For Kawakita plots, values of 1/b show that batches containing microcrystalline cellulose were less cohesive. The plot of tensile strength signifies that granulated batches achieved maximum crushing strength faster at low pressure. Formulations containing maize starch were shown to have higher percent porosity, and granulated batches gave higher values for apparent density-pressure relationship and lower friability values. Tablets produced by the wet granulation method showed better compression and compaction properties than those formulated by direct compression.

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Section: Compaction and Compression Propertiessupporting

confidence: 91%

“…The ability of a powder bed to produce a strong tablet mechanically is called compactibility, while compressibility has to do with how a powder bed is compressed and consequently reduces volume 5 .…”

Section: Introductionmentioning

confidence: 99%

Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves

et al. 2021

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“…During the decompression phase, tablet expansion occurs even after ejection due to elastic recovery. This indicates that the plastic behaviour of powder during compression and elastic recovery during decompression plays a vital role during compaction [56,59]. Along with plastic and elastic deformation of powder bed during compression, the compressibility of powder will also be affected by fragmentation and brittle fracture of the particle [42].…”

Section: Assessment Of Mechanical Properties Of Compression Vehiclementioning

confidence: 99%

“…Therefore, the test for lubricant sensitivity is usually performed using magnesium stearate as a model lubricating agent. Lubricant sensitivity can be determined by compressing a blend of compression vehicles with an increasing proportion of magnesium stearate, and the compressed tablets are evaluated for the time of disintegration and % friability [28,56]. Fragmenting materials show less sensitivity to metal stearate due to "lubricant Free Surfaces" during compression.…”

Section: Compressed Tabletmentioning

confidence: 99%

Compression Vehicle: A Technical Review

Somnache¹,

Pai

Godbole³

et al. 2022

GJPB

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“…Goyanes et al had utilised the method of wet massing with slight modification for preparation of co-processed excipients [15]. Wet granulation technique can be completed either in fluid bed granulators or high shear blenders.…”

Section: Wet Granulationmentioning

confidence: 99%

A Review on Multifunctional Excipients with Regulatory Considerations

Swami

Chavan

Chakankar

et al. 2021

JPRI

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The practice of multifunctional excipients is gaining more and more attention as it simplifies the process of drug formulation by substituting the necessity of using mixture of many excipients. The multifunctional excipients are the class of excipients which includes pre-–processed and co-processed excipients and it provides added functionalities to the formulation. Functionality of an excipient is a useful property which helps in manufacturing and improves quality as well as applicability of the material. Researchers have identified that single component excipients may not always give the required results during development and manufacturing of definite API, hence they are concentrating to develop multifunctional excipients which will have improved quality that will fulfil the requirements of the formulation experts in terms of cost. The cost of new excipient development is very high as it demands toxicity studies, hence the industry is now focusing on co-processing of approved materials. The demand for directly compressible co-processed excipients has also increased due to the availability of high-speed tableting machines, time saving in Abbreviated New Drug Application (ANDA), simplified validation and stability of active ingredients. The intention of this review article is to highlight applicability and increasing attention focusing the benefits of co-processed excipients. Their advantages over conventional blend of excipients include development methods, testing and also highlighting their regulatory consideration.

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Compaction and tableting properties of composite particles of microcrystalline cellulose and crospovidone engineered for direct compression

Cited by 13 publications

References 31 publications

Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves

Compressional Physics of Binary Mixture of Dried Andrographis paniculata and Moringa oleifera Leaves

Compression Vehicle: A Technical Review

A Review on Multifunctional Excipients with Regulatory Considerations

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