In this article, we study for p∈(1,∞) the Lp‐realization of the vector‐valued Schrödinger operator Lu:=prefix div (Q∇u)+Vu. Using a noncommutative version of the Dore–Venni theorem due to Monniaux and Prüss, we prove that the Lp‐realization of scriptL, defined on the intersection of the natural domains of the differential and multiplication operators which form scriptL, generates a strongly continuous contraction semigroup on Lp(double-struckRd;double-struckCm). We also study additional properties of the semigroup such as extension to L1, positivity, ultracontractivity and prove that the generator has compact resolvent.