Companion Animals as Sentinels for Community Exposure to Industrial Chemicals: The Fairburn, GA, Propyl Mercaptan Case Study

Maciejewski, Ross; Glickman, Nita W.; Moore, George E.; Zheng, Cheng; Tyner, Benjamin; Cleveland, William S.; Ebert, David S.; Glickman, Larry T.

doi:10.1177/003335490812300313

Cited by 13 publications

(11 citation statements)

References 7 publications

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“…Banfield EPR data were linked with Antech Diagnostics electronic laboratory reports from over 18,000 private veterinary practices [ 117 ]. Resultant publications on dog health have covered vaccine safety [ 19 , 107 , 118 , 119 ], tick infestation [ 108 ] and toxic exposure [ 115 ]. However, NCASP surveillance was limited by confidentiality issues, delayed dissemination of results and difficulties in managing such large volumes of data [ 117 ].…”

Section: Reviewmentioning

confidence: 99%

Approaches to canine health surveillance

O’Neill

Church

McGreevy

et al. 2014

Canine Genet Epidemiol

118

146

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Effective canine health surveillance systems can be used to monitor disease in the general population, prioritise disorders for strategic control and focus clinical research, and to evaluate the success of these measures. The key attributes for optimal data collection systems that support canine disease surveillance are representativeness of the general population, validity of disorder data and sustainability. Limitations in these areas present as selection bias, misclassification bias and discontinuation of the system respectively. Canine health data sources are reviewed to identify their strengths and weaknesses for supporting effective canine health surveillance. Insurance data benefit from large and well-defined denominator populations but are limited by selection bias relating to the clinical events claimed and animals covered. Veterinary referral clinical data offer good reliability for diagnoses but are limited by referral bias for the disorders and animals included. Primary-care practice data have the advantage of excellent representation of the general dog population and recording at the point of care by veterinary professionals but may encounter misclassification problems and technical difficulties related to management and analysis of large datasets. Questionnaire surveys offer speed and low cost but may suffer from low response rates, poor data validation, recall bias and ill-defined denominator population information. Canine health scheme data benefit from well-characterised disorder and animal data but reflect selection bias during the voluntary submissions process. Formal UK passive surveillance systems are limited by chronic under-reporting and selection bias. It is concluded that active collection systems using secondary health data provide the optimal resource for canine health surveillance.

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Section: Reviewmentioning

confidence: 99%

Approaches to canine health surveillance

O’Neill

Church

McGreevy

et al. 2014

Canine Genet Epidemiol

118

146

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“…The pets, particularly the dogs and cats, are of particular interest, given that they share the habitat with humans and they respond to toxic assaults similar to their owners (Backer et al 2001). Thus, many studies have been designed to reveal the shared exposure of humans and dog/cats to different environmental toxicants of anthropogenic origin, such as asbestos (Glickman et al 1983;Backer et al 2001), tobacco smoke (Ka et al 2014), industrial pollutants (Maciejewski et al 2008;Bischoff et al 2010), pesticides (Knapp et al 2013) or smog (Heyder & Takenaka 1996;Calderon-Garciduenas et al 2001), among others. Most of these studies have found associations between exposure and elevation of the selected biomarkers, as well as correlations between the incidence of diseases related to exposure to such pollutants between pets and humans.…”

Section: Introductionmentioning

confidence: 99%

Are pet dogs good sentinels of human exposure to environmental polycyclic aromatic hydrocarbons, organochlorine pesticides and polychlorinated biphenyls?

Ruiz-Suárez

Rial

Boada

et al. 2015

Journal of Applied Animal Research

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Several studies have shown that pet dogs and cats, since they share the habitat with people, could be good sentinels for human exposure to environmental pollutants. However, some publications have suggested that dogs could efficiently metabolize and eliminate some persistent organic pollutants (POPs), which are accumulated by humans throughout life. For this reason, the role of domestic dogs as sentinels could not be appropriate, at least for certain contaminants. To test this hypothesis, we designed this study in which we determined plasma levels of 56 POPs (11 organochlorine pesticides [OCPs], 18 polychlorinated biphenyls [PCBs] and 27 polycyclic aromatic hydrocarbons) in the plasma of 87 dogs and 100 people from the same area (the Canary Islands, Spain). We detected most of these contaminants in the plasma of both species, although the frequencies of detection, concentrations and profiles were very different from each other, especially for ∑OCPs and ∑PCBs. In light of these results, we can conclude that, although they share the environment, sources of exposure to these pollutants and/or the metabolic capabilities do not seem to be comparable between the two species, so that the dog does not seem to be a good sentinel for human exposure to these contaminants.

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“…Molybdenum is an essential trace element for nearly all organisms [ 100 , 101 ]. It is found in human tissues in a range from 0.001 to 0.4 mg/kg of tissue, with the lowest values in the blood and the highest in the kidneys and liver [ 73 , 102 ]. The average value in the soft tissues is <0.075 mg/kg and, in the skeleton, <0.48 mg/kg [ 103 ].…”

Section: Discussionmentioning

confidence: 99%

Title Changes in the Mineral Composition of Rat Femoral Bones Induced by Implantation of LNCaP Prostate Cancer Cells and Dietary Supplementation

et al. 2020

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Prostate cancer (PCa) is the second most frequent cancer in men and the fifth most common cause of death worldwide, with an estimated 378,553 deaths in 2020. Prostate cancer shows a strong tendency to form metastatic foci in the bones. A number of interactions between cancer cells attacking bones and cells of the bone matrix lead to destruction of the bone and growth of the tumour. The last few decades have seen increased interest in the precise role of minerals in human health and disease. Tumour cells accumulate various minerals that promote their intensive growth. Bone, as a storehouse of elements, can be a valuable source of them for the growing tumour. There are also reports suggesting that the presence of some tumours, e.g., of the breast, can adversely affect bone structure even in the absence of metastasis to this organ. This paper presents the effect of chronic dietary intake of calcium, iron and zinc, administered in doses corresponding maximally to twice their level in a standard diet, on homeostasis of selected elements (Ca, K, Zn, Fe, Cu, Sr, Ni, Co, Mn and Mo) in the femoral bones of healthy rats and rats with implanted cancer cells of the LNCaP line. The experiment was conducted over 90 days. After the adaptation period, the animals were randomly divided into four dietary groups: standard diet and supplementation with Zn, Fe and Ca. Every dietary group was divided into experimental group (with implanted cancer cells) and control group (without implanted cancer cells). The cancer cells (LnCaP) were implanted intraperitoneally in the amount 1 × 106 to the rats at day 90 of their lifetime. Bone tissue was dried and treated with microwave-assisted mineral digestation. Total elemental content was quantified by ICP-MS. Student’s t-test and Anova or Kruskal–Wallis tests were applied in order to compare treatment and dietary groups. In the case of most of the diets, especially the standard diet, the femoral bones of rats with implanted LNCaP cells showed a clear downward trend in the content of the elements tested, which may be indicative of slow osteolysis taking place in the bone tissue. In the group of rats receiving the standard diet, there were significant reductions in the content of Mo (by 83%), Ca (25%), Co (22%), Mn (13%), K (13%) and Sr (9%) in the bone tissue of rats with implanted LNCaP cells in comparison with the control group receiving the same diet but without LNCaP implantation. Supplementation of the rat diet with calcium, zinc and iron decreased the frequency of these changes relative to the standard diet, which may indicate that the diet had an inhibitory effect on bone resorption in conditions of LNCaP implantation. The principal component analysis (PCA) score plot confirms the pronounced effect of implanted LNCaP cells and the standard diet on bone composition. At the same time, supplementation with calcium, zinc and iron seems to improve bone composition. The microelements that most often underwent quantitative changes in the experimental conditions were cobalt, manganese and molybdenum.

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Companion Animals as Sentinels for Community Exposure to Industrial Chemicals: The Fairburn, GA, Propyl Mercaptan Case Study

Cited by 13 publications

References 7 publications

Approaches to canine health surveillance

Approaches to canine health surveillance

Are pet dogs good sentinels of human exposure to environmental polycyclic aromatic hydrocarbons, organochlorine pesticides and polychlorinated biphenyls?

Title Changes in the Mineral Composition of Rat Femoral Bones Induced by Implantation of LNCaP Prostate Cancer Cells and Dietary Supplementation

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