Muhammadiyah an Islamic organization in Indonesia continues to spread its wings to the international realm. PCIM is present as a form of Muhammadiyah's progress in the international arena and brings Muhammadiyah to an active role in the global realm in building world civilization. PCIM Egypt was the originator of the first PCIM in the world and was followed up to now reach 31 PCIMs spread across various countries in the world. It was founded with various functions and roles as a form of internationalization of the Muhammadiyah da'wah movement. This research has the following objectives: (1) to determine the role of PCIM Egypt in the internationalization of the Muhammadiyah da'wah movement, and (2) to determine the opportunities and challenges of PCIM Egypt in the internationalization of the Muhammadiyah da'wah movement. This research uses qualitative research with a descriptive approach. The data sources for this research are the chairman of PCIM Egypt and the Forza Egypt Booklet. The data collection technique uses interviews with related sources and several journals related to PCIM. Based on the research results, it can be concluded that (1) PCIM Egypt's active role in the internationalization of the Muhammadiyah movement with its main function as a glue for brotherhood, a forum for developing cadres, a transformer and mediator for the organization, as well as a charity in the international realm. PCIM Egypt continues to form cadres who are very competent in their fields to carry out da'wah movements in the context of internationalizing Muhammadiyah. (2) As an opportunity and also a challenge for PCIM Egypt, namely regarding legality or official permission from the government for Muhammadiyah organizations in Egypt, due to socio-political factors in Middle Eastern countries in general.