Automated office blood pressure (AOBP) has emerged as valuable tool to assess patient's blood pressure (BP) status, but the lack of strong evidences to establish a threshold value for hypertension diagnosis limits its use in clinical practice. We aimed at synthesizing the published literature through a meta-analysis of studies comparing AOBP with other BP measurement techniques and at analysing the differences between AOBP and physician's office BP, non-physician's office BP, daytime ambulatory BP monitoring (ABPM) and home BP monitoring (HBPM). We searched PubMed database for articles published up to April 2018; eligible studies compared AOBP with office and/or out-of-office measurement techniques and reported the BP differences or BP values obtained. Twenty-six studies, for a total of 7,116 patients were included in the analysis. AOBP values were lower than physician (systolic blood pressure, SBP-10.48 mmHg [95% CI-13.15 to-7.81] / diastolic blood pressure, DBP-4.44 mmHg [95% CI-6.07 to-2.80]) and non-physician office ones (SBP-6.89 mmHg [95% CI-8.75 to-5.04] / DBP-3.82 mmHg [95% CI-4.86 to-2.78]). No significant differences were detected between AOBP and daytime ABPM (SBP-1.85 mmHg [95% CI-4.50 to 0.79] / DBP 0.12 mmHg [95% CI-1.42 to 1.66]) and HBPM (SBP-2.65 mmHg [95% CI-8.42 to 3.12]) / DBP-1.67 mmHg [95% CI-4.20 to 0.87]). AOBP readings did not differ significantly from out-of-office blood pressure, still remaining an office technique; it may improve hypertension diagnosis by overcoming some of office BP limitations, including the white-coat effect.