Comparação dos efeitos da infiltração com bupivacaína, lidocaína e tramadol na cicatrização de feridas em ratos

Hancı, Volkan; Hakimoğlu, Sedat; Özaçmak, Haktan; Bektaş, Sibel; Özaçmak, Hale Sayan; Özdamar, Şükrü Oğuz; Yurtlu, Serhan; Turan, İşıl Özkoçak

doi:10.1590/s0034-70942012000600005

Cited by 7 publications

(5 citation statements)

References 42 publications

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“…In the study by Fedder et al (26) , the in vitro cytotoxic effect of lidocaine on the proliferation of human fibroblasts was dependent on the concentration of the anesthetic used. The results reported by Fedder et al (26) corroborate the justification that the present study presents different results from those of Rodrigues et al (10) and Hanci et al (21) due to the different concentrations of lidocaine used. However, similar results were reported by Drucker et al (20) , in which no significant difference was observed in collagenization, and by Harris et al (27) , who did not find a cytotoxic effect or a significant reduction in proliferation in cultures of fibroblasts treated with lidocaine.…”

Section: Microscopic Evaluationsupporting

confidence: 90%

“…Histological analysis of fibroblast proliferation and collagenization revealed possibly delayed healing in the GS and GL animals; however, this was not confirmed by the statistical analysis of the data, which was insufficient to create an unfavorable final result that could impede the surgical healing process. These results contradict those of Rodrigues et al (10) , Hanci et al (21) , and Shekho et al (18) , who reported an effect of lidocaine on collagenization in rats.…”

Section: Microscopic Evaluationcontrasting

confidence: 78%

“…Drucker et al (20) reported that, in addition to the concentration of lidocaine used being higher than the concentration used in the present study, the route of administration differed, which may have interfered with angiogenesis, justifying the results found in the current study differing from theirs. Hanci et al (21) used a higher concentration of lidocaine than that used here in addition to the different experimental models, which could explain the reported differences. Mononuclear and polymorphonuclear cells were absent in the GL on the third day of healing, unlike in the GC, in which a slight presence of mononuclear cells was observed in 33.3% of the animals and polymorphonuclear cells in 66.7%.…”

Section: Microscopic Evaluationmentioning

confidence: 81%

“…Vessel proliferation in animals treated with lidocaine has been controversial in the literature. Drucker et al (20) reported significantly less vascularization in guinea pigs subjected to infiltration with lidocaine, whereas Hanci et al (21) reported that rats treated with lidocaine showed increased vascularization compared to those treated with saline. In the present study, the tumescent procedure with lidocaine did not influence angiogenesis.…”

Section: Microscopic Evaluationmentioning

confidence: 99%

“…Waite et al (22) reported an increase in the number of neutrophils in rats treated with lidocaine, which influenced local inflammation. Hanci et al (21) reported significant inflammation in rats treated with lidocaine compared to those treated with saline. These results, contrary to those found in the present study, are explained by the higher concentration of lidocaine used by these authors, which could be the cause of the greater inflammation.…”

Section: Microscopic Evaluationmentioning

confidence: 99%

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Closure of defects in a geometric figure pattern associated with tumescent anesthesia with lidocaine in rabbits (Oryctolagus cuniculus)

et al. 2022

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The use of tumescent anesthesia with lidocaine can provide better intra- and postoperative analgesia that would benefit extensive reconstructive surgery. However, lidocaine can interfere with the healing process. Therefore, this study aimed to assess the local interference of the healing of induced and closed skin defects in a geometric pattern associated with the use of tumescent anesthesia with lidocaine in rabbits. Furthermore, we assessed its influence on cardiorespiratory parameters and postoperative analgesia. This study included 27 rabbits divided into three groups: GC (without the use of tumescence), GS (use of tumescence with 0.9% NaCl solution), and GL (use of tumescent anesthesia with lidocaine). There was no statistically significant intergroup difference in any stage of the wound healing process on macroscopic evaluations, in the angiogenesis process, or in the process of collagenization and fibroblast deposition. There were significant differences in heart rate (lower in GL), respiratory rate (higher in GC), mean arterial pressure (higher in GL), and expired concentration of isoflurane (lower in GL). There was no significant intergroup difference in the von Frey filament test or the visual analog scale score used to evaluate postoperative analgesia. We concluded that tumescent anesthesia with lidocaine does not impair postoperative tissue repair. Its use features benefits such as reducing the volume of inhaled anesthetic, maintaining the anesthesia plan, stable heart and respiratory rates, and lower hypotension during the surgical procedure.

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