Comparación de índices de riesgo de mortalidad en pacientes pediátricos con choque séptico

Association of Vasopressin Plus Catecholamine Vasopressors vs Catecholamines Alone With Atrial Fibrillation in Patients With Distributive Shock

“…In absolute terms, this means 24 more occurrences (95% CI, 6 to 55) of digital ischemia per 1000 patients treated with vasopressin. When the 4 studies at high risk of bias were excluded, the resultant estimate was not significantly different. Definitions varied for this outcome; however, when the analysis was limited to the 6 studies that specifically described “digital ischemia,” the resultant estimate did not change significantly.…”

“…When the 4 studies at high risk of bias were excluded, the resultant estimate was not significantly different. Definitions varied for this outcome; however, when the analysis was limited to the 6 studies that specifically described “digital ischemia,” the resultant estimate did not change significantly. Thus, evidence was not downgraded for indirectness but, because it was a post hoc outcome, it was downgraded for risk of bias.…”

“…Five trials were multicenter . Twenty-two studies included patients with septic shock . Two studies evaluated patients with post–cardiac surgery vasoplegia .…”

“…Two studies evaluated patients with post–cardiac surgery vasoplegia . Vasopressin was the intervention in 13 trials, whereas 9 studied terlipressin, 1 studied selepressin, and 1 studied pituitrin (a mixture of vasopressin and oxytocin) . One 3-group study compared vasopressin vs terlipressin vs norepinephrine alone .…”