Comparación de las características clínicas en pacientes con carcinoma folicular de tiroides y carcinoma de células de Hürthle

Lorea, Ander Ernaga; Bermejo, Iranzu Migueliz; Apiñániz, Emma Anda; Arribas, Javier Pineda; García, Marta Toni; Esteban, Juan Pablo Martínez de; Serrano, Ana María Insausti

doi:10.1016/j.endinu.2017.12.006

Cited by 5 publications

(5 citation statements)

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“…Likewise, in another study, distant metastasis at presentation was significantly less often diagnosed in OFTC patients than in FTC patients (4% vs. 13%; p value 0.03) [17]. This is in contrast to a previously published study in which OFTC patients tended more likely to present with distant metastases (8% vs. 3%, p value 0.078) [18]. Patients presenting with risk factors such as advanced tumor stages might have been more likely transferred to a tertiary care center which has the permission to use higher radiation doses and explaining our relevant number of cM1 patients.…”

Section: Discussionmentioning

confidence: 61%

“…Independent prognostic factors for diseasespecific survival are described inconsistently. Male gender, advanced age of patients, advanced TNM (tumor, nodes, metastasis) stages, and residual tumor after thyroidectomy have been noted to influence outcome negatively [11,13,18,29,30,34,[38][39][40]. In our study, we could also identify these risk factors in the univariate analysis.…”

Section: Discussionmentioning

confidence: 86%

“…The authors observed that more OFTC patients developed recurrent disease (24% vs. 8%, p value 0.05) [13]. In a similar setting, persistence/recurrence occurred in OFTC patients also more frequently (13% in the OFTC and 4% in the FTC group, p value 0.011) [18]. In general, recurrence ranges from 11 to 43% in OFTC patients [6,[30][31][32].…”

Section: Discussionmentioning

confidence: 89%

“…All our patients were treated with total or near total thyroidectomy followed by initial RIT. In previously published studies, the percentage of thyroidectomy ranged from 27 to 100% [6,11,13,17,18,28,[30][31][32]34]. Surgery for thyroid carcinoma is an important component of a multimodal treatment approach.…”

Section: Discussionmentioning

confidence: 99%

“…However, Jillaed et al have demonstrated the association of improved survival in OFTC patients who were treated with radioiodine therapy (RIT) [16]. Recently, three studies have shown a similar prognosis of FTC and OFTC patients, especially if influencing risk factors are matched [11,17,18]. In most of the previously published studies, patients with different standard care procedures were included.…”

Section: Introductionmentioning

confidence: 99%

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Clinical impact of follicular oncocytic (Hürthle cell) carcinoma in comparison with corresponding classical follicular thyroid carcinoma

Wenter

Albert

Ahmaddy

et al. 2020

Eur J Nucl Med Mol Imaging

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Purpose There are controversial debates if patients with Hürthle cell carcinoma, also known as oxyphilic or oncocytic cell follicular thyroid carcinoma, have a poorer outcome. In this study, we systematically evaluated the clinical outcome in a large patient cohort following thyroidectomy and initial I-131 radioactive iodine therapy (RIT). Methods We retrospectively evaluated a total of 378 patients with diagnosed oncocytic follicular Hürthle cell carcinoma (OFTC) (N = 126) or with classical follicular thyroid carcinoma (FTC) (N = 252). Patients received thyroidectomy and complementary I-131 RIT. Clinical data regarding basic demographic characteristics, tumor grade, persistent disease and recurrence during followup, and disease-free, disease-specific, and overall survival were collected during follow-up of 6.9 years (interquartile range 3.7; 11.7 years). Univariate and multivariate analyses were used to identify factors associated with disease-related and overall survival. Results Before and after matching for risk factors, recurrence was significantly more frequently diagnosed in OFTC patients during follow-up (17% vs. 8%; p value 0.037). Likewise, OFTC patients presented with a reduced mean disease-free survival of 17.9 years (95% CI 16.0-19.8) vs. 20.1 years (95% CI 19.0-21.1) in FTC patients (p value 0.027). Multivariate analysis revealed OFTC (HR 0.502; 95% CI 0.309-0.816) as the only independent prognostic factor for disease-free survival. Distant metastases of OFTC patients were significantly less iodine-avid (p value 0.014). Mean disease-specific and overall survival did not differ significantly (p value 0.671 and 0.687) during follow-up of median 6.9 years (3.7; 11.7 years). Conclusions Our study suggests that recurrence is more often seen in OFTC patients. OFTC patients have a poorer prognosis for disease-free survival. Thus, OFTC and FTC behave differently and should be categorized separately. However, patients suffering from OFTC present with the same overall and disease-specific survival at the end of follow-up indifferent to FTC patients after initial RIT.

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Section: Discussionmentioning

confidence: 61%