During the context of COVID-19, educational processes migrated to a strictly virtual scenario, so the quantity of information grew in such a way that techniques such as data mining or machine learning contributed to generating knowledge for decision-making. In this sense, it is relevant to define the state of the art of the contributions of data mining in the university environment, and from there, to see in perspective how these could be applied in scenarios of return to the face-to-face. In this sense, a systematic review of the literature is carried out, based on scientific evidence extracted from the Taylor & Francis, ERIC and Scopus databases. A qualitative content analysis approach and the PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) statement were used to extract the findings published in scientific articles. The results were that educational data mining was applied to a greater extent in the field of “teaching”, and it was focused on the search for patterns and predictive models to improve student performance, reduce student dropout, improve the student’s quality of life, and teacher performance. In addition, as a resource for data extraction, university learning management systems (LMS) were used to a greater extent. It is concluded that tools such as data mining should be implemented as academic management policies, achieving a prospective on indicators linked to the improvement of student learning and performance.