Comparaison des effets vasculaires du sulfate de magnésium et de la nicardipine pendant la circulation extracorporelle

A, Delhumeau; Granry, J.C.; Cottineau, C.; Bukowski, J.G.; Corbeau, J.J.; Moreau, Xavier

doi:10.1016/s0750-7658(95)70012-0

Cited by 8 publications

(1 citation statement)

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“…In addition, the role of preoperative MGS administration in controlling intraoperative hypertension and reducing the intraoperative variability of arterial pressure has been studied in patients with hypertension undergoing cataract surgery with local anesthesia ( 20 ). It has been shown that MGS, as a safe drug without any hemodynamic instability, is as effective as nicardipine in controlling arterial pressure during cardiac procedures ( 21 ) and shortens postoperative time for extubation in elective CABG surgeries ( 22 ). Some previous studies have demonstrated that the infusion of 1.5 to 2 mg/kg of lidocaine from the fifth to the second minute before laryngoscopy can blunt the increase in HR, SBP, MAP and catecholamine levels associated with intubation ( 23 - 25 ).…”

Section: Discussionmentioning

confidence: 99%

The Effect of Intravenous Magnesium Sulfate and Lidocaine in Hemodynamic Responses to Endotracheal Intubation in Elective Coronary Artery Bypass Grafting: a Randomized Controlled Clinical Trial

et al. 2014

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Background:There have been many concerns about alteration in hemodynamic parameters within and shortly after endotracheal intubation (ETI) in patients scheduled for elective coronary artery bypass grafting (CABG).Objectives:We compared the attenuation effect of magnesium sulfate and lidocaine on hemodynamic responses after ETI, in patients undergoing CABG.Patients and Methods:In this randomized controlled trial 150 patients undergoing elective CABG were enrolled. Included patients were randomly allocated to three groups and received lidocaine (1.5 mg/kg), magnesium sulfate (50 mg/kg within five minute), or normal saline, 90 seconds before ETI. Baseline hemodynamic parameters including heart rate (HR), systolic blood pressure (SBP), diastolic blood pressure (DBP), and mean arterial pressure (MAP) were recorded immediately before anesthesia induction, before intubation, immediately after intubation, and at second and fifth minutes after intubation.Results:The baseline hemodynamic variables had no deference among the three groups. HR between intubation and five minute after intubation was significantly lower in two groups received lidocaine or magnesium sulfate in comparison with placebo group. Lidocaine induced more than 20% decrease in HR and MAP immediately after intubation; hence, lidocaine group showed significant MAP reduction in comparison with the two other groups.Conclusions:Lidocaine induced hemodynamic instability but premedication of magnesium sulfate maintained hemodynamic stability after intubation. Therefore, in patients undergoing CABG who received high-dose intravenous analgesic for general anesthesia, the administration of magnesium sulfate might result in maintaining hemodynamic stability after ETI in comparison with lidocaine.

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