Comparative activation kinetics of mammalian plasminogens

Wohl, Robert C.; Sinio, Leonida; Summaria, Louis; Robbins, Kenneth C.

doi:10.1016/0167-4838(83)90165-6

Cited by 58 publications

(37 citation statements)

References 35 publications

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“…In dogs (Tables 1, 3, 4, 5, 6, 7 and 10), except for the Plg when it is measured by activation with SK, the values of all the fibrinolytic assays are quite similar to the values in humans, as reported by Wohl et al (1983).…”

Section: Fibrinolytic Parameterssupporting

confidence: 65%

Comparative Fibrinolysis

Casanave¹,

Tentoni²

2014

Fibrinolysis and Thrombolysis

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Section: Fibrinolytic Parameterssupporting

confidence: 65%

Comparative Fibrinolysis

Casanave¹,

Tentoni²

2014

Fibrinolysis and Thrombolysis

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“…Kinetic data were collected and analyzed as described under "Experimental Procedures." (12,13,61). 8 For these experiments, we used a full-length SK construct (i.e.…”

Section: Resultsmentioning

confidence: 99%

Plasminogen Substrate Recognition by the Streptokinase-Plasminogen Catalytic Complex Is Facilitated by Arg253, Lys256, and Lys257 in the Streptokinase β-Domain and Kringle 5 of the Substrate

Tharp

Laha

Panizzi

et al. 2009

Journal of Biological Chemistry

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“…To induce liver regeneration, a recombinant adenoviral vector that expresses human urokinase from the RSV-long terminal repeat (LTR) promoter, Ad.RSV-uPA, was constructed. Human uPA can activate plasminogen across species (27). For comparison with Ad.RSV-uPA administration, control studies were done on mice that received an irrelevant control adenovirus or two-thirds partial hepatectomy.…”

Section: Resultsmentioning

confidence: 99%

Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo.

Lieber

Peeters

Meuse

et al. 1995

Proc. Natl. Acad. Sci. U.S.A.

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Retrovirus-mediated gene transfer into hepatocytes in vivo results in long-term gene expression. Limitations include the need to remove two-thirds of the liver and the relatively low frequency of gene transfer. To increase gene transfer without surgical hepatectomy, mouse hepatocytes were transduced in vivo with a recombinant adenovirus that transiently expressed urokinase, resulting in high rates of asynchronous liver regeneration. During the regenerative phase, in vivo retroviral-mediated gene transfer in hepatocytes resulted in 5-to 10-fold greater transduction efficiencies than that obtained by conventional partial hepatectomy. In 3-4 weeks, the architecture and microscopic structure of the recipient livers were normal. The two-viral system of achieving permanent transgene expression from hepatocytes in vivo offers an alternative approach to current ex vivo and in vivo gene-transfer models.

show abstract

Comparative activation kinetics of mammalian plasminogens

Cited by 58 publications

References 35 publications

Comparative Fibrinolysis

Comparative Fibrinolysis

Plasminogen Substrate Recognition by the Streptokinase-Plasminogen Catalytic Complex Is Facilitated by Arg253, Lys256, and Lys257 in the Streptokinase β-Domain and Kringle 5 of the Substrate

Adenovirus-mediated urokinase gene transfer induces liver regeneration and allows for efficient retrovirus transduction of hepatocytes in vivo.

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