Comparative activities of daptomycin and several agents against staphylococcal blood isolates. Glycopeptide tolerance

Picazo, Juan J.; Betriú, Carmen; Rodríguez-Avial, Iciar; Culebras, Esther; López-Fabal, Fátima; Gómez, Manuel

doi:10.1016/j.diagmicrobio.2011.02.009

Cited by 16 publications

(6 citation statements)

References 39 publications

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“…Reduced susceptibility to vancomycin (MIC >2 μg/mL) was found in 3% of CoNS isolates in our study, similar to a 2% rate in a recent review of bloodstream infections caused by CoNS [ 23 ]. As was the case with other recent summaries of susceptibility data from Spain [ 20 – 22 ], no CoNS isolates were resistant to vancomycin, linezolid, or daptomycin.…”

Section: Discussionsupporting

confidence: 75%

Epidemiology and Prognosis of Coagulase-Negative Staphylococcal Endocarditis: Impact of Vancomycin Minimum Inhibitory Concentration

et al. 2015

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This study describes coagulase-negative staphylococcal (CoNS) infective endocarditis (IE) epidemiology at our institution, the antibiotic susceptibility profile, and the influence of vancomycin minimum inhibitory concentration (MIC) on patient outcomes. One hundred and three adults with definite IE admitted to an 850-bed tertiary care hospital in Barcelona from 1995-2008 were prospectively included in the cohort. We observed that CoNS IE was an important cause of community-acquired and healthcare-associated IE; one-third of patients involved native valves. Staphylococcus epidermidis was the most frequent species, methicillin-resistant in 52% of patients. CoNS frozen isolates were available in 88 patients. Vancomycin MICs of 2.0 μg/mL were common; almost all cases were found among S. epidermidis isolates and did not increase over time. Eighty-five patients were treated either with cloxacillin or vancomycin: 38 patients (Group 1) were treated with cloxacillin, and 47 received vancomycin; of these 47, 27 had CoNS isolates with a vancomycin MIC <2.0 μg/mL (Group 2), 20 had isolates with a vancomycin MIC ≥2.0 μg/mL (Group 3). One-year mortality was 21%, 48%, and 65% in Groups 1, 2, and 3, respectively (P=0.003). After adjusting for confounders and taking Group 2 as a reference, methicillin-susceptibility was associated with lower 1-year mortality (OR 0.12, 95% CI 0.02-0.55), and vancomycin MIC ≥2.0 μg/mL showed a trend to higher 1-year mortality (OR 3.7, 95% CI 0.9-15.2; P=0.069). Other independent variables associated with 1-year mortality were heart failure (OR 6.2, 95% CI 1.5-25.2) and pacemaker lead IE (OR 0.1, 95%CI 0.02-0.51). In conclusion, methicillin-resistant S.epidermidis was the leading cause of CoNS IE, and patients receiving vancomycin had higher mortality rates than those receiving cloxacillin; mortality was higher among patients having isolates with vancomycin MICs ≥2.0 μg/mL.

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Section: Discussionsupporting

confidence: 75%

Epidemiology and Prognosis of Coagulase-Negative Staphylococcal Endocarditis: Impact of Vancomycin Minimum Inhibitory Concentration

et al. 2015

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“…alternative to vancomycin because of its high level of antimicrobial and antibiofilm activity, as previously reported. 10,32 According to our data, daptomycin not only inhibited all the tested strains but also showed high bactericidal activity for both bacterial species (77.78% for S. aureus and 78.95% for S. epidermidis). These results are in accordance with those of other studies.…”

Section: Discussionmentioning

confidence: 64%

In vitro susceptibility of Staphylococcus aureus and Staphylococcus epidermidis isolated from prosthetic joint infections

et al. 2012

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Prosthetic joint infections (PJI) are severe complications in Orthopedics, with Staphylococcus aureus and Staphylococcus epidermidis being the most commonly isolated pathogens. The variable antimicrobial susceptibility found in these microorganisms, along with the increasing number of methicillin-resistant strains, increases the difficulty of antibiotic selection and makes it necessary to perform individual susceptibility studies to select the optimal antibiotic treatment. The aim of this study was to evaluate the in vitro susceptibility pattern of 35 clinical strains isolated from PJI (17 S. aureus and 18 S. epidermidis) against rifampin, vancomycin, tygecicline, clindamycin, cotrimoxazole, cloxacillin, ciprofloxacin, daptomycin and fosfomycin. In vitro susceptibility assays were performed using the broth microdilution method and agar dilution for fosfomycin. MBC was also determined. Tygecicline and daptomycin showed the highest antimicrobial activity with low MIC 90 values, and no resistant strains were detected. On the other hand, ciprofloxacin and cloxacillin exhibited a poor antimicrobial effect with a high percentage of nonsusceptible strains in both species. Bactericidal activity rates revealed the bacteriostatic behavior of rifampin, tygecicline, cotrimoxazole, fosfomycin and clindamycin, whereas vancomycin and cloxacillin showed species-and strain-dependent behavior. Daptomycin and ciprofloxacin were observed to be efficient bactericidal agents against the tested strains. According to our data, rifampin, tigecycline, daptomycin and fosfomycin showed high in vitro activity against most staphylococcal strains isolated from the PJIs tested, although daptomycin seems to be the best alternative to vancomycin therapy.

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“…30 Glycopeptide-resistant staphylococci have not yet been detected in Spain, [31][32][33] although an increase in the prevalence of staphylococci with reduced susceptibility to glycopeptides as well as staphylococcal strains tolerant to glycopeptides have been observed in recent years. 31,32,34 Given the broader spectrum of vancomycin over that of cephalosporins with regard to the grampositive bacteria most commonly isolated in POE and the drastic reduction in the incidence of infection caused by the change in antibiotic prophylaxis noted in our study (0.03%), we feel that addition of vancomycin and gentamicin to the irrigating solution is suitable for preventing POE after cataract surgery in our hospital. The incidence of POE in the second part of our study period is very similar to that noted by various authors who used intracameral cefuroxime (range 0.04-0.06%) [12][13][14][15][16][17]35 as well as by others who added antibiotics to the irrigating solution (0.06%).…”

Section: Discussionmentioning

confidence: 99%

Impact of Changes in Antibiotic Prophylaxis on Postoperative Endophthalmitis in a Spanish Hospital

Asencio¹,

Huertas²,

Carranza³

et al. 2014

Ophthalmic Epidemiology

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Comparative activities of daptomycin and several agents against staphylococcal blood isolates. Glycopeptide tolerance

Cited by 16 publications

References 39 publications

Epidemiology and Prognosis of Coagulase-Negative Staphylococcal Endocarditis: Impact of Vancomycin Minimum Inhibitory Concentration

Epidemiology and Prognosis of Coagulase-Negative Staphylococcal Endocarditis: Impact of Vancomycin Minimum Inhibitory Concentration

In vitro susceptibility of Staphylococcus aureus and Staphylococcus epidermidis isolated from prosthetic joint infections

Impact of Changes in Antibiotic Prophylaxis on Postoperative Endophthalmitis in a Spanish Hospital

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