Comparative Analyses of the Transport Proteins Encoded within the Genomes of nine &lt;b&gt;&lt;i&gt;Bifidobacterium&lt;/i&gt;&lt;/b&gt; Species

The array of ion channels and transporters expressed in cell membranes-collectively referred to as the transportome-is a complex and multifunctional molecular machinery; in particular, at the plasma membrane level it finely tunes the exchange of biomolecules and ions acting as a functionally adaptive interface that accounts for dynamic plasticity in the response to environmental fluctuations and stressors. The transportome is responsible for the definition of membrane potential and its variations, participates in the transduction of extracellular signals, and acts as a filter for most of the substances entering and leaving the cell, thus enabling the homeostasis of many cellular parameters. For all these reasons, physiologists have long been interested in the expression and functionality of ion channels and transporters, both in physiological and pathological settings, and across the different domains of life. Today, thanks to the high-throughput technologies of the post-genomic era, the omics approach to the study of the transportome is becoming increasingly popular in different areas of biomedical research, allowing for a more comprehensive, integrated, and functional perspective of this complex cellular apparatus. This paper represents a first effort for a systematic review of the scientific literature on this topic. Here we report a brief overview of all those studies-both primary and meta-analyses-that looked at the transportome as a whole, regardless of the biological problem or the models they used. A later section is devoted to the methodological aspect by reviewing the most important public databases with transporter annotations. Before conclusions, limitations and future perspectives are also discussed.

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An Insider’s Perspective about the Pathogenic Relevance of Gut Bacterial Transportomes

Zafar,

Saier Jr.

2024

Microb Physiol

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Background: The gut microbiome is integral to host health, hosting complex interactions between the host and numerous microbial species in the gastrointestinal tract. Key among the molecular mechanisms employed by gut bacteria are transportomes, consisting of diverse transport proteins crucial for bacterial adaptation to the dynamic, nutrient-rich environment of the mammalian gut. These transportomes facilitate the movement of a wide array of molecules, impacting both the host and the microbial community. Summary: This communication explores the significance of transportomes in gut bacteria, focusing on their role in nutrient acquisition, competitive interactions among microbes, and potential pathogenicity. It delves into the transportomes of key gut bacterial species like E. coli, Salmonella, Bacteroides, Lactobacillus, Clostridia, and Bifidobacterium, examining the functions of predicted transport proteins. The overview synthesizes recent research efforts, highlighting how these transportomes influence host-microbe interactions and contribute to the microbial ecology of the gut. Key Messages: Transportomes are vital for the survival and adaptation of bacteria in the gut, enabling the import and export of various nutrients and molecules. The complex interplay of transport proteins not only supports bacterial growth and competition but also has implications for host health, potentially contributing to pathogenic processes. Understanding the pathogenic potential of transportomes in major gut bacterial species provides insights into gut health and disease, offering avenues for future research and therapeutic strategies.

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Comparative Analyses of the Transport Proteins Encoded within the Genomes of nine <b><i>Bifidobacterium</i></b> Species

Cited by 5 publications

References 104 publications

Mechanism analysis of methionine inhibiting growth of Bifidobacterium bifidum

Mechanism analysis of methionine inhibiting growth of Bifidobacterium bifidum

The Emerging Concept of Transportome: State of the Art

An Insider’s Perspective about the Pathogenic Relevance of Gut Bacterial Transportomes

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