Comparative analysis of 2‐week glycaemic profile of healthy versus mild gestational diabetic pregnant women using flash glucose monitoring system: an observational study

Nigam, Aruna; Sharma, Sumedha; Varun, Neha; Munjal, Y P; Prakash, Anupam

doi:10.1111/1471-0528.15849

Cited by 14 publications

(15 citation statements)

References 17 publications

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“…Dalfra et al 33 found that the GV index of pregnant women with GDM was significantly higher than that of pregnant women with NDP. Nigam et al 34 also showed that pregnant women with GDM had significantly higher GV index values than pregnant women with NDP. Contrary to the above-mentioned reports, Cypryk et al 35 found no significant differences in blood glucose fluctuations between pregnant women with GDM and pregnant women with NDP.…”

Section: Importance Of Gvmentioning

confidence: 94%

“…Four studies have shown that the blood glucose fluctuations of pregnant women with GDM are greater than those of pregnant women with NDP. [31][32][33][34] Mazze et al 31 found that the GV of the GDM group was significantly higher than that of the NDP group. Similarly, Su et al 32 showed that the GV of the GDM group was higher than those of the NDP group and the non-pregnant healthy control group.…”

Section: Importance Of Gvmentioning

confidence: 99%

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<p>A Review of Research Progress on Glycemic Variability and Gestational Diabetes</p>

et al. 2020

DMSO

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Gestational diabetes mellitus (GDM) is associated with many adverse obstetric outcomes and neonatal outcomes, including preeclampsia, Cesarean section, and macrosomia. Active screening and early diabetes control can reduce the occurrence of adverse outcomes. Glycosylated hemoglobin (HbA1c) only reflects average blood glucose levels, but not glycemic variability (GV). Studies have shown that GV can cause a series of adverse reactions, and good control of GV can reduce the incidence of adverse pregnancy outcomes in patients with GDM. In order to provide clinicians with a better basis for diagnosis and treatment, this study reviewed the measurement, evaluation, and control of GV, the importance of GV for patients with GDM, and correlations between GV and maternal and neonatal outcomes.

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Section: Importance Of Gvmentioning

confidence: 94%

Section: Importance Of Gvmentioning

confidence: 99%

<p>A Review of Research Progress on Glycemic Variability and Gestational Diabetes</p>

et al. 2020

DMSO

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“…The targets of blood glucose control during pregnancy are a fasting blood glucose below 95 mg/dL and a 2-h postprandial blood glucose below 120 mg/dL (33); however, in this study, the levels peaked at 30 or 60 min after the meal in the MTT. In recent years, a continuous glucose monitoring system has been developed to study blood glucose fluctuations in detail during pregnancy (34); however, an MTT is useful for assessing postprandial blood glucose levels and identifying high-risk patients requiring insulin therapy (19,22). Further research is needed to determine whether the GDM control target for blood glucose 2 h after a meal is adequate.…”

Section: Hba1cmentioning

confidence: 99%

A comparison of meal tolerance test and oral glucose tolerance test for predicting insulin therapy in patients with gestational diabetes

Hijikata

Higa²,

Ichijo³

et al. 2021

Food & Nutrition Research

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Aims: To identify factors predicting a need for insulin therapy in gestational diabetes mellitus (GDM) by comparing plasma glucose (PG) levels in a 75-g oral glucose tolerance test (75-g OGTT) with those in a 500-kcal meal tolerance test (MTT) containing 75 g of carbohydrate. Subjects and methods: The MTT was performed in 61 patients who diagnosed with GDM by a 75-g OGTT (age, 33.2 ± 4.5 years; prepregnancy body mass index, 22.6 ± 4.7 kg/m2; number of gestational weeks, 25.1 ± 6.4 weeks). PG and serum insulin levels were measured before the meal and up to 180 min after the meal. The insulin secretion capacity and resistance index were calculated. Results: PG levels increased from 86.8 ± 8.8 mg/dL at fasting to 132.7 ± 20.1 mg/dL at 30 min, and 137.8 ± 27.7 mg/dL at 60 min after MTT in the 35 patients with needed insulin therapy; these levels were significantly higher than those in the 26 patients, who only needed diet therapy. The patients with needed insulin therapy had significantly higher fasting PG levels in the 75-g OGTT, PG levels at fasting and 30 min after the MTT, and homeostasis model assessment of insulin resistance (HOMA-IR), and a significantly lower disposition index (DI) and insulin index than patients treated by diet alone. Receiver operating characteristic curve analysis was performed for factors involved in insulin therapy, with the following cutoff values: fasting PG in the 75-g OGTT, 92 mg/dL; PG 30 min after MTT, 129 mg/dL; HOMA-IR, 1.51; DI, 3.9; HbA1c, 5.4%. Multivariate analysis revealed that the 30-min PG level after MTT and HOMA-IR predicted insulin therapy. Conclusion: PG levels at 30 min after MTT may be useful for identifying patients with GDM, who need insulin therapy.

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“…Lifestyle modifications, including diet consultation and physical exercise, are considered the first-line intervention and may sufﬁce for most patients [ 10 ]. Women with GDM who are on insulin therapy receive more attention from doctors and researchers, while women with GDM with mild dysglycemia who control their condition with diet alone receive much less attention, although this group may account for the majority of patients with GDM [ 12 ].…”

Section: Introductionmentioning

confidence: 99%

Comparing the Efficacies of Telemedicine and Standard Prenatal Care on Blood Glucose Control in Women With Gestational Diabetes Mellitus: Randomized Controlled Trial

Tian¹,

Zhang²,

Huang³

et al. 2021

JMIR Mhealth Uhealth

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Background Gestational diabetes mellitus (GDM) can usually be well controlled by health education and lifestyle management, resulting in better pregnancy outcomes. However, standard clinical prenatal care, which consists of clinic visits every 2 weeks, may not provide sufficient management for women with GDM. Telemedicine demonstrates a potential to fill this gap. Objective The objective of this study was to investigate whether health education and lifestyle management delivered through a WeChat group chat was more effective in controlling blood glucose (BG) than standard clinical prenatal care among women with GDM. Methods In this multicenter randomized controlled trial, women with GDM diagnosed by an oral glucose tolerance test between 23 and 30 (+6) gestational weeks were randomized to a WeChat group chat–based BG management group or a routine clinical prenatal care group. The primary outcome was the change in the glycemic qualification rate during the follow-up period in both groups. The secondary outcomes were pregnancy outcomes. Results A total of 309 women with GDM participated in the trial, with 162 women randomized to the control group and 147 to the intervention group. No significant differences in baseline characteristics were found between the control and intervention groups. Participants were further divided into 4 groups according to gestational weeks at enrollment for further analysis. The glycemic qualification rate of the intervention group was higher than that of the control group at nearly all time points in Groups 1 to 3, among which 3 time points reached statistical significance: Group 1 at T3 (54.8% vs 83.3%) and Group 2 at T3 (62.5% vs 80.0%) and T7 (75.0% vs 100%). The glycemic qualification rate gradually increased as gestational weeks progressed in both groups, regardless of the intervention method. None of the pregnancy outcomes measured, including delivery mode, premature rupture of the membranes, preterm birth, infant's birth weight, and postpartum hemorrhage, were significantly different between the control and intervention groups. Conclusions This multicenter randomized controlled trial that assessed women with noninsulin-dependent GDM demonstrated that additional instant messaging platforms, such as WeChat, used for health education and lifestyle intervention in China tend to be more effective for BG control than standard clinical prenatal care alone. Trial Registration ClinicalTrials.gov NCT03748576; https://clinicaltrials.gov/ct2/show/NCT03748576

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Comparative analysis of 2‐week glycaemic profile of healthy versus mild gestational diabetic pregnant women using flash glucose monitoring system: an observational study

Cited by 14 publications

References 17 publications

<p>A Review of Research Progress on Glycemic Variability and Gestational Diabetes</p>

<p>A Review of Research Progress on Glycemic Variability and Gestational Diabetes</p>

A comparison of meal tolerance test and oral glucose tolerance test for predicting insulin therapy in patients with gestational diabetes

Comparing the Efficacies of Telemedicine and Standard Prenatal Care on Blood Glucose Control in Women With Gestational Diabetes Mellitus: Randomized Controlled Trial

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