Comparative Analysis of Adult Stem Cell Niches

Fioret, Bryan; Hatzopoulos, Antonis K.

doi:10.1002/9781118695746.ch5

Cited by 1 publication

(1 citation statement)

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“…Previous studies show the vasculature is an integral component of most well characterized stem cell niches in various organs, such as the bone marrow and the subventricular zone (SVZ) in the brain (Li and Clevers, 2010; Fioret and Hatzopoulos, 2014). Our data suggest this biological strategy extends to the heart, with the coronary vessels serving as the CSC niche.…”

Section: Discussionmentioning

confidence: 99%

Endothelial Cells Contribute to Generation of Adult Ventricular Myocytes during Cardiac Homeostasis

et al. 2014

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SUMMARY Cardiac tissue undergoes renewal with low rates. Although resident stem cell populations have been identified to support cardiomyocyte turnover, the source of the cardiac stem cells and their niche remain elusive. Using Cre/Lox-based cell lineage tracing strategies, we discovered that labeling of endothelial cells in the adult heart yields progeny with cardiac stem cell characteristics that express Gata4 and Sca1. Endothelial-derived cardiac progenitor cells were localized in the arterial coronary walls with quiescent and proliferative cells in the media and adventitia layers, respectively. Within myocardium, we identified labeled cardiomyocytes organized in clusters of single-cell origin. Pulse-chase experiments showed that generation of individual clusters was rapid, but confined to specific regions of the heart, primarily in the right anterior and left posterior ventricular walls and the junctions between the two ventricles. Our data demonstrate that endothelial cells are an intrinsic component of the cardiac renewal process.

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Section: Discussionmentioning

confidence: 99%