Comparative Analysis of an Image-Guided Versus a Non–Image-Guided Setup Approach in Terms of Delivered Dose to the Parotid Glands in Head-and-Neck Cancer IMRT

Duma, Marciana Nona; Kampfer, S.; Wilkens, Jan J.; Schuster, Tibor; Molls, M.; Geinitz, Hans

doi:10.1016/j.ijrobp.2009.09.047

Cited by 35 publications

(23 citation statements)

References 27 publications

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“…In In addition, no significant correlation was noted between the different reductions of ROI volumes to each other. It is acknowledged that radiotherapy itself can induce volume reduction in the PGs and weight loss is not correlated to this decrease [9,19,20]. As every organ has specific radiation sensitivity and a different reaction to weight loss, we believe that an assessment of one ROI volume might not be able to predict another's ROI volume change.…”

Section: Discussionmentioning

confidence: 88%

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Adaptive radiotherapy for soft tissue changes during helical tomotherapy for head and neck cancer

et al. 2012

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Section: Discussionmentioning

confidence: 88%

“…The total doses were 64 Gy for postoperative and 70 Gy for definitely treated patients, respectively. The treatment planning and delivery were previously described [9]. All plans were normalized to the prescribed dose to the median of the PTV.…”

Section: Methodsmentioning

confidence: 99%

Adaptive radiotherapy for soft tissue changes during helical tomotherapy for head and neck cancer

et al. 2012

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“…Twenty-six papers described both anatomic and dosimetric changes during the course of radiation [2,4,6,[11][12][13][15][16][17]31,34,36,38,39,[41][42][43][44]46,48,54,59,61,63,65,66]. Two studies reported on dosimetric changes without referring to anatomic changes [18,51].…”

Section: Anatomic and Dosimetric Changesmentioning

confidence: 99%

“…Sanguineti et al [62] studied weekly CT scans of eighty-five patients and concluded that the PG shrinkage is not linear (PGs shrunk most during the first half of treatment). Thirty-eight papers reported on PG anatomic changes [2,4,6,7,9,12,13,[15][16][17][31][32][33][34][35][36][37][38][39][40][41][42][43][44][45]47,48,50,53,56,57,59,60,[62][63][64][65][66]. The most common reported anatomic changes were volume loss (Table S1) and medial shifts of the PGs [17,[32][33][34]37,42,44,45,48,51,...…”

Section: Parotid Glandmentioning

confidence: 99%

Identifying patients who may benefit from adaptive radiotherapy: Does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help?

Brouwer

Steenbakkers

Langendijk

et al. 2015

Radiotherapy and Oncology

151

147

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In the last decade, many efforts have been made to characterize anatomic changes of head and neck organs at risk (OARs) and the dosimetric consequences during radiotherapy. This review was undertaken to provide an overview of the magnitude and frequency of these effects, and to investigate whether we could find criteria to identify head and neck cancer patients who may benefit from adaptive radiotherapy (ART). Possible relationships between anatomic and dosimetric changes and outcome were explicitly considered. A literature search according to PRISMA guidelines was performed in MEDLINE and EMBASE for studies concerning anatomic or dosimetric changes of head and neck OARs during radiotherapy. Fifty-one eligible studies were found. The majority of papers reported on parotid gland (PG) anatomic and dosimetric changes. In some patients, PG mean dose differences between planning CT and repeat CT scans up to 10 Gy were reported. In other studies, only minor dosimetric effects (i.e. <1 Gy difference in PG mean dose) were observed as a result of significant anatomic changes. Only a few studies reported on the clinical relevance of anatomic and dosimetric changes in terms of complications or quality of life. Numerous potential selection criteria for anatomic and dosimetric changes during radiotherapy were found and listed. The heterogeneity between studies prevented unambiguous conclusions on how to identify patients who may benefit from ART in head and neck cancer. Potential pre-treatment selection criteria identified from this review include tumour location (nasopharyngeal carcinoma), age, body mass index, planned dose to the parotid glands, the initial parotid gland volume, and the overlap volume of the parotid glands with the target volume. These criteria should be further explored in well-designed and well-powered prospective studies, in which possible relationships between anatomic and dosimetric changes and outcome need to be established.

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“…Although it is clear that the use of an accurate and precise image‐guidance technique results in the best patient positioning over the course of treatment, the cost associated with imaging has to be considered, in terms of the additional patient‐absorbed dose 5 , 6 , 7 and/or machine time.…”

Section: Introductionmentioning

confidence: 99%

A retrospective tomotherapy image‐guidance study: analysis of more than 9,000 MVCT scans for ten different tumor sites

Sánchez-Rubio

Rodríguez-Romero

Castro

2014

J Applied Clin Med Phys

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The purpose of this study was to quantify the systematic and random errors for various disease sites when daily MVCT scans are acquired, and to analyze alternative off‐line verification protocols (OVP) with respect to the patient setup accuracy achieved. Alignment data from 389 patients (9,418 fractions) treated at ten different anatomic sites with daily image‐guidance (IG) on a helical tomotherapy unit were analyzed. Moreover, six OVP were retrospectively evaluated. For each OVP, the frequency of the residual setup errors and additional margins required were calculated for the treatment sessions without image guidance. The magnitude of the three‐dimensional vector displacement and its frequency were evaluated for all OVP. From daily IG, the main global systematic error was in the vertical direction (4.4–9.4 mm), and all rotations were negligible (less than 0.5°) for all anatomic sites. The lowest systematic and random errors were found for H&N and brain patients. All OVP were effective in reducing the mean systematic error to less than 1 mm and 0.2° in all directions and roll corrections for almost all treatment sites. The treatment margins needed to adapt the residual errors should be increased by 2–5 mm for brain and H&N, around 8 mm in the vertical direction for the other anatomic sites, and up to 19 mm in the longitudinal direction for abdomen patients. Almost 70% of the sessions presented a setup error of 3 mm for OVPs with an imaging frequency above 50%. Only for brain patients it would be feasible to apply an OVP because the residual setup error could be compensated for with a slight margin increase. However, daily imaging should be used for anatomic sites of difficult immobilization and/or large interfraction movement.PACS numbers: 87.55.‐x, 87.56.‐v

show abstract

Comparative Analysis of an Image-Guided Versus a Non–Image-Guided Setup Approach in Terms of Delivered Dose to the Parotid Glands in Head-and-Neck Cancer IMRT

Cited by 35 publications

References 27 publications

Adaptive radiotherapy for soft tissue changes during helical tomotherapy for head and neck cancer

Adaptive radiotherapy for soft tissue changes during helical tomotherapy for head and neck cancer

Identifying patients who may benefit from adaptive radiotherapy: Does the literature on anatomic and dosimetric changes in head and neck organs at risk during radiotherapy provide information to help?

A retrospective tomotherapy image‐guidance study: analysis of more than 9,000 MVCT scans for ten different tumor sites

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