Comparative analysis of antigenic strength and in vivo serum antibodies concentration of tetanus toxoid vaccine adsorbed in Pakistan

Zahid, Asif Shah; Farooqi, Hafiz Muhammad Umer; Ahsan, Ali; Farooqi, Muhammad Awais; Kausar, Farzana; Muhammad, Javed; Ahmad, A.

doi:10.1016/j.sjbs.2022.103337

Cited by 9 publications

(5 citation statements)

References 18 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Hepatitis B and Hepatitis C infections are characterized by short-term infection within the first six months after someone is infected with these pathogens. The severity can range from mild illness with few or no symptoms to a severe condition requiring immediate hospitalization and intensive care [20,21]. Some adults can get rid of the virus without treatment, and those that can clear the virus become immune and do not develop clinical symptoms and infection with subsequent exposure.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Trends in Hepatitis B & C Virus among Blood Donors in Pakistan: A Regional Transfusion Center Study

Zorob,

Farooqi,

Ahsan

et al. 2023

Livers

Self Cite

View full text Add to dashboard Cite

Around 118.5 million blood donations are collected annually to save precious lives. The donated blood may also be associated with blood-borne infections. With around 247 million population, Pakistan is an endemic country for viral hepatitis, and there is a high risk of having asymptomatic blood donors among healthy donors. Viral hepatitis is 2.5% prevalent in the general population, and blood donation and its screening have become grave health concerns for Pakistani health authorities. Asymptomatic viral hepatitis needs screening to rule out subliminally diseased individuals, as recommended by the World Health Organization. Knowing the prevalence of the transfusion transmissible infectious (TTIs) agents in healthy blood donors helps assess the disease burden in any population, boosts treatment rates, and precludes dreaded complications in the affected people. The objective of the current study was to determine the prevalence and trends of significant TTIs among blood donors visiting the Armed Forces Institute of Transfusion (AFIT), Rawalpindi, Pakistan. A total of 15,405 blood donors were screened for HBV, HCV, HIV, malaria, and syphilis during this cross-sectional descriptive study. Most donors had an O-positive blood group; AB-negative donors were only 0.7%. Out of the study population, we reported 1.06% HBV, 0.54% HCV, 0.19% HIV, and 0.31% syphilis-positive asymptomatic blood donors. However, no blood donor was found positive for malaria. The Punjab province was reported as the most burdened for TTIs, and youngsters aged 18–27 years were mainly positive, indicating the need to conduct national-level awareness campaigns about TTIs. The stakeholders need to strengthen the blood collection guidelines, and effective performance should be strictly monitored through internal and external audits considering the aim of reaching non-infectious blood products.

show abstract

Section: Discussionmentioning

confidence: 99%

Prevalence and Trends in Hepatitis B & C Virus among Blood Donors in Pakistan: A Regional Transfusion Center Study

Zorob,

Farooqi,

Ahsan

et al. 2023

Livers

Self Cite

View full text Add to dashboard Cite

show abstract

“…For the quantitative variable, the normality assumption was evaluated by using the Shapiro–Wilk and Kolmogorov–Smirnov tests. ANOVA and independent-sample t -test were applied to compare choroidal thickness in diffuse and focal groups, and a post hoc test was performed for inter-group comparisons [ 31 , 32 ]. The p -value of ≤0.05 was considered significant.…”

Section: Discussionmentioning

confidence: 99%

Choroidal Thickness in Different Patterns of Diabetic Macular Edema

Amjad¹,

Lee

Farooqi

et al. 2022

JCM

View full text Add to dashboard Cite

This observational study investigated the changes in choroidal thickness (ChT) in different patterns of diabetic macular edema (DME) based on image processing using enhanced-depth imaging spectral-domain optical coherence tomography (EDI-SD-OCT). Participants with ocular conditions affecting the fundus view, including retinal diseases, were excluded. After observing the patient’s medical record, multicolor fundus photos, thickness maps, and subtypes of DME were diagnosed according to the criteria reported by the Early Treatment Diabetic Retinopathy Study (ETDRS). Edema was classified as focal or diffuse and was subdivided into cystic macular edema (CME), CME with subretinal fluid (CME+), and spongy macular edema (SME). Image processing was performed on the B-scan images from SD-OCT to segment the choroid layer and obtain the choroid thickness. A total of 159 eyes of 81 patients (46 males and 35 females; 57.53 ± 9.78 years of age), and 57 eyes of 30 healthy individuals (age 57.34 ± 8.76 years) were enrolled in this study. Out of 159 eyes, 76 had focal macular edema (FME), 13 exhibited SME, and 51 presented CME. Among those with cystic macular edema, 19 eyes showed subretinal fluid (CME+). The average choroidal thickness in FME, diffuse SME, CME, and CME+ was 216.95 ± 52.94 µm, 243.00 ± 46.34 µm, 221.38 ± 60.78 µm, and 249.63 ± 53.90 µm, respectively. The average choroidal thickness in age-matched controls was 213.88 ± 45.60 µm. Choroidal thickness increases with the severity of edema; choroidal thickness was higher in diffuse macular edema than in FME. However, choroidal thickness increased in cystic macular edema with subretinal fluid (CME+).

show abstract

“…They may include lifestyle changes, drugs, and invasive procedures. Regularly, healthcare professionals must assess progress and modify the treatment plan [ 32 , 33 ].…”

Section: Current Treatment Options For Atherosclerosismentioning

confidence: 99%

Focused Ultrasound, an Emerging Tool for Atherosclerosis Treatment: A Comprehensive Review

Imtiaz,

Farooqi,

Bhatti

et al. 2023

Life

Self Cite

View full text Add to dashboard Cite

Focused ultrasound (FUS) has emerged as a promising noninvasive therapeutic modality for treating atherosclerotic arterial disease. High-intensity focused ultrasound (HIFU), a noninvasive and precise modality that generates high temperatures at specific target sites within tissues, has shown promising results in reducing plaque burden and improving vascular function. While low-intensity focused ultrasound (LIFU) operates at lower energy levels, promoting mild hyperthermia and stimulating tissue repair processes. This review article provides an overview of the current state of HIFU and LIFU in treating atherosclerosis. It focuses primarily on the therapeutic potential of HIFU due to its higher penetration and ability to achieve atheroma disruption. The review summarizes findings from animal models and human trials, covering the effects of FUS on arterial plaque and arterial wall thrombolysis in carotid, coronary and peripheral arteries. This review also highlights the potential benefits of focused ultrasound, including its noninvasiveness, precise targeting, and real-time monitoring capabilities, making it an attractive approach for the treatment of atherosclerosis and emphasizes the need for further investigations to optimize FUS parameters and advance its clinical application in managing atherosclerotic arterial disease.

show abstract

Comparative analysis of antigenic strength and in vivo serum antibodies concentration of tetanus toxoid vaccine adsorbed in Pakistan

Cited by 9 publications

References 18 publications

Prevalence and Trends in Hepatitis B & C Virus among Blood Donors in Pakistan: A Regional Transfusion Center Study

Prevalence and Trends in Hepatitis B & C Virus among Blood Donors in Pakistan: A Regional Transfusion Center Study

Choroidal Thickness in Different Patterns of Diabetic Macular Edema

Focused Ultrasound, an Emerging Tool for Atherosclerosis Treatment: A Comprehensive Review

Contact Info

Product

Resources

About