Comparative analysis of apocarotenoids and phenolic constituents of <i>Crocus sativus</i> stigmas from 11 countries: Ecological impact

Мykhailenko, Olha; Безрук, Иван; Ivanauskas, Liudas; Georgiyants, Victoriya

doi:10.1002/ardp.202100468

Cited by 9 publications

(6 citation statements)

References 68 publications

(112 reference statements)

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“…Limonium avei (De Not.) Brullo and Erben [31]; Schinus molle (L.) [32]; Thymus vulgaris [28]; Crocus sativus L. [33]; Glycyrrhiza glabra [34]; Dianthus rupicola [20]; Lavandula angustifolia L. [35]; Hypericum taxa (Guttiferae) [36]; Fuscoporia torulosa (Basidiomycetes) [27]; Fuscoporia torulosa [27]; Thymus vulgaris [28]; Bupleurum fontanesii [37]; Crithmum maritimum [38]; Ferulago campestris [39]; Origanum onites and Thymus capitatus [40] Clostridium difficile 2 Angelica archangelica L. [41]; Echinophora spinosa (Apiaceae) [42] Clostridium perfringens 3 Angelica archangelica L. (Apiaceae) [41]; Satureja montana L. [43]; Echinophora spinosa (Apiaceae) [42] Table 1. Cont.…”

Section: Bacillus Cereus 17unclassified

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Plants with Antimicrobial Activity Growing in Italy: A Pathogen-Driven Systematic Review for Green Veterinary Pharmacology Applications

et al. 2022

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Drug resistance threatening humans may be linked with antimicrobial and anthelmintic resistance in other species, especially among farm animals and, more in general, in the entire environment. From this perspective, Green Veterinary Pharmacology was proven successful for the control of parasites in small ruminants and for the control of other pests such as varroa in bee farming. As in anthelmintic resistance, antimicrobial resistance (AMR) represents one of the major challenges against the successful treatment of infectious diseases, and antimicrobials use in agriculture contributes to the spread of more AMR bacterial phenotypes, genes, and proteins. With this systematic review, we list Italian plants with documented antimicrobial activity against possible pathogenic microbes. Methods: The literature search included all the manuscripts published since 1990 in PubMed, Web of Science, and Scopus using the keywords (i) “antimicrobial, plants, Italy”; (ii) “antibacterial, plant, Italy”; (iii) “essential oil, antibacterial, Italy”; (iv) “essential oil, antimicrobial, Italy”; (v) “methanol extract, antibacterial, Italy”; (vi) “methanol extract, antimicrobial, Italy”. Results: In total, 105 manuscripts that documented the inhibitory effect of plants growing in Italy against bacteria were included. One hundred thirty-five plants were recorded as effective against Gram+ bacteria, and 88 against Gram−. This will provide a ready-to-use comprehensive tool to be further tested against the indicated list of pathogens and will suggest new alternative strategies against bacterial pathogens to be employed in Green Veterinary Pharmacology applications.

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Section: Bacillus Cereus 17unclassified

“…Caralluma europaea [73]; Crocus sativus [33]; Helichrysum araxinum [74]; Schinus molle (L.) [32]; Cannabis sativa [75];…”

Section: Bacterium (Gram+) Number Of Plant Species Plant Namementioning

confidence: 99%

Plants with Antimicrobial Activity Growing in Italy: A Pathogen-Driven Systematic Review for Green Veterinary Pharmacology Applications

et al. 2022

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“…Different origins and harvesting years impact the crocin profiles of saffron samples [34]. Furthermore, environmental factors like solar radiation and air temperature influence the content of apocarotenoids and phenolic constituents in saffron, with variations observed across countries like Ukraine and India [35]. On the other hand, the geoclimatic characteristics of the territory play a crucial role in determining the chemical composition of saffron, leading to distinct final products [36].…”

Section: Introductionmentioning

confidence: 99%

The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents

Elfardi,

El Boukhari,

Fatimi

et al. 2024

DDC

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Plants and plant extracts have long been acknowledged as valuable resources for the development of therapeutic formulations for various diseases. Among them, numerous plants and plant-derived products have demonstrated cytotoxic and/or anti-tumor properties. Saffron, particularly due to its major compounds, namely crocin, crocetin, and safranal, stands out as a promising candidate in this regard. Our research undertakes a literature review, reaffirming the antioxidant, anti-inflammatory, and, notably, anti-tumor properties of saffron and its major constituents. Additionally, this study examines relevant patent documents, highlighting innovative applications for saffron and its major compounds in cancer therapy. The review discusses the progress in purifying the compounds extracted from saffron and assesses their impact on cytotoxic trial outcomes, the potential synergies between certain saffron compounds and established cytotoxic molecules, and the limitations of the patents examined, particularly concerning reported clinical evidence. Researchers who focus on advances in oncology will know from our findings the evolution of the patent landscape regarding cytotoxic and/or anti-tumor therapeutic applications using saffron or its main compounds. Moreover, investigators can draw inspiration from patents leveraging traditional knowledge, particularly from Chinese medicine, to clarify specific active molecules and their mechanisms of action and can expedite the translation of these findings into clinically relevant interventions, potentially enhancing cancer therapy outcomes.

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“…As minor components, which also contribute to the spice color and biological effects, there are a series of glycosidic derivatives of kaempferol ( Figure 1 ) [ 11 ] and quercetin [ 12 ]. Other minor components that contribute to the peculiar aroma of saffron are volatile compounds related to isophorone [ 13 , 14 ].…”

Section: Introductionmentioning

confidence: 99%

The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituents

Butnariu

Quispe

Herrera‐Bravo

et al. 2022

Oxidative Medicine and Cellular Longevity

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Crocus species are mainly distributed in North Africa, Southern and Central Europe, and Western Asia, used in gardens and parks as ornamental plants, while Crocus sativus L. (saffron) is the only species that is cultivated for edible purpose. The use of saffron is very ancient; besides the use as a spice, saffron has long been known also for its medical and coloring qualities. Due to its distinctive flavor and color, it is used as a spice, which imparts food preservative activity owing to its antimicrobial and antioxidant activity. This updated review discusses the biological properties of Crocus sativus L. and its phytoconstituents, their pharmacological activities, signaling pathways, and molecular targets, therefore highlighting it as a potential herbal medicine. Clinical studies regarding its pharmacologic potential in clinical therapeutics and toxicity studies were also reviewed. For this updated review, a search was performed in the PubMed, Science, and Google Scholar databases using keywords related to Crocus sativus L. and the biological properties of its phytoconstituents. From this search, only the relevant works were selected. The phytochemistry of the most important bioactive compounds in Crocus sativus L. such as crocin, crocetin, picrocrocin, and safranal and also dozens of other compounds was studied and identified by various physicochemical methods. Isolated compounds and various extracts have proven their pharmacological efficacy at the molecular level and signaling pathways both in vitro and in vivo. In addition, toxicity studies and clinical trials were analyzed. The research results highlighted the various pharmacological potentials such as antimicrobial, antioxidant, cytotoxic, cardioprotective, neuroprotective, antidepressant, hypolipidemic, and antihyperglycemic properties and protector of retinal lesions. Due to its antioxidant and antimicrobial properties, saffron has proven effective as a natural food preservative. Starting from the traditional uses for the treatment of several diseases, the bioactive compounds of Crocus sativus L. have proven their effectiveness in modern pharmacological research. However, pharmacological studies are needed in the future to identify new mechanisms of action, pharmacokinetic studies, new pharmaceutical formulations for target transport, and possible interaction with allopathic drugs.

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Comparative analysis of apocarotenoids and phenolic constituents of Crocus sativus stigmas from 11 countries: Ecological impact

Abstract: The chemical compositions of 15 saffron samples from 11 countries (

Cited by 9 publications

References 68 publications

Plants with Antimicrobial Activity Growing in Italy: A Pathogen-Driven Systematic Review for Green Veterinary Pharmacology Applications

Plants with Antimicrobial Activity Growing in Italy: A Pathogen-Driven Systematic Review for Green Veterinary Pharmacology Applications

The Multifaceted Therapeutic Potential of Saffron: An Overview Based on Research and Patents

The Pharmacological Activities of Crocus sativus L.: A Review Based on the Mechanisms and Therapeutic Opportunities of its Phytoconstituents

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